Protein detail
ATL4
ADAMTS-like protein 4 (ADAMTSL-4) (Thrombospondin repeat-containing protein 1)
Entry name ATL4 | UniProt ID | EVMP score 0.38 |
Frequency 2 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPredicted secreted proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
ADAMTS-like protein 4 (ADAMTSL-4) (Thrombospondin repeat-containing protein 1)
Protein Class
Disease related genesHuman disease related genesPredicted secreted proteins
Protein Function
- Disease related genes
- Human disease related genes:Congenital malformations:Congenital malformations of eye
- Predicted secreted proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
DKFZP434K1772TSRC1
Gene Description
ADAMTS like 4
Chromosome
1
Position
150549369-150560937
Frequency
2
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificintestineCell SpecificCytotrophoblastsSingle-Nuclei Brain Specificmammillary bodySecretome LocationSecreted in other tissuesSecretome FunctionReceptor
Function & Pathway
Protein Function
- Disease related genes
- Human disease related genes:Congenital malformations:Congenital malformations of eye
- Predicted secreted proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Clinical-translation mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
19 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | GO_Intercell | No | No | Yes | No | No |
| intracellular | intracellular | OmniPath | No | No | Yes | No | No |
| ecm_regulator | ecm_regulator | Matrisome | Yes | No | Yes | No | No |
| ecm_regulator | ecm_regulator | OmniPath | Yes | No | Yes | No | No |
| secreted_peptidase | secreted_peptidase | OmniPath | No | No | Yes | No | No |
| secreted | secreted | UniProt_keyword | No | No | Yes | No | No |
| secreted | secreted | UniProt_location | No | No | Yes | No | No |
| secreted | secreted | HPA_secretome | No | No | Yes | No | No |
| secreted | secreted | OmniPath | No | No | Yes | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 40689422 |
Sequence, Structure & Domains
Sequences
Length
1,074
Mass
116,545
Sequence
MENWTGRPWLYLLLLLSLPQLCLDQEVLSGHSLQTPTEEGQGPEGVWGPWVQWASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLPPRPPRHPEALLPRGQGPRPQTSPETLPLYRTQSRGRGGPLRGPASHLGREETQEIRAARRSRLRDPIKPGMFGYGRVPFALPLHRNRRHPRSPPRSELSLISSRGEEAIPSPTPRAEPFSANGSPQTELPPTELSVHTPSPQAEPLSPETAQTEVAPRTRPAPLRHHPRAQASGTEPPSPTHSLGEGGFFRASPQPRRPSSQGWASPQVAGRRPDPFPSVPRGRGQQGQGPWGTGGTPHGPRLEPDPQHPGAWLPLLSNGPHASSLWSLFAPSSPIPRCSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCELNCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDDSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWAVDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVISSPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCNSQPCSQRPDDQCKDSSPHCPLVVQARLCVYPYYTATCCRSCAHVLERSPQDPS
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6UY14-1; Sequence=Displayed; Name=2; IsoId=Q6UY14-2; Sequence=VSP_052183, VSP_052184; Name=3; IsoId=Q6UY14-3; Sequence=VSP_055759
Alternative Sequence
411; E -> EAPLLPLRHAFFLLPGAGSGDSTG (in isoform 3); 854..877; CSAECGTGIQRRSVVCLGSGAALG -> VSPEPPAISCILGNHAQDTSAFPA (in isoform 2); 878..1074; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
103..119; Polar residues; 132..152; Basic and acidic residues; 206..226; Polar residues; 310..323; Gly residues
Domain (FT)
48..93; TSP type-1 1; 723..782; TSP type-1 2; 783..842; TSP type-1 3; 845..909; TSP type-1 4; 910..969; TSP type-1 5; 970..1026; TSP type-1 6; 1029..1066; PLAC
Region
77..342; Disordered
Clinical Relevance
Antibody