Protein detail
CF299
Cilia- and flagella-associated protein 299
Entry name CF299 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Cilia- and flagella-associated protein 299
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
C4orf22
Gene Description
Cilia and flagella associated protein 299
Chromosome
4
Position
80335730-80963750
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization2
Tissue SpecificbrainCell SpecificAstrocytes
Function & Pathway5
Protein Function
Predicted intracellular proteins
Cellular Component (2)
Molecular Function
Biological Process (3)
Mediation Categories
Other mediation
Relations & Evidence6
Ligand-Receptor Signaling (4)
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 39363010 |
Sequence, Structure & Domains6
Sequences
Length
233
Mass
26,869
Sequence
MDQEEGLKALDNIVTQFNAYEDFLDSQITTVDLYYLEDETLARQLVELGYRGTGERVKREDFEARKAAIEIARLAERAQQKTLTSAGKDLQDNFLTALAMREEDNRSGKLSSVIFIRDRNSHGQEISGYIDYAHRLKTEDFEVYFTGKKRLLPRPTDISFYNWDADIAVSNSSPNYQVIADNPEGLLFRYKRDRKILNVDPKAQPGDNSTRITILTELYVQAVIFDHISRRKT
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=2; IsoId=Q6V702-2; Sequence=Displayed; Name=1; IsoId=Q6V702-1; Sequence=VSP_037233; Name=3; IsoId=Q6V702-3; Sequence=VSP_037234, VSP_037235
Alternative Sequence
111; S -> SLNQQETDAAHILKKQLA (in isoform 1); 112..156; SVIFIRDRNSHGQEISGYIDYAHRLKTEDFEVYFTGKKRLLPRPT -> AGVQWHHLGSLQPLPPGFKEFSCFSLPSGWDYRHAPPHPVRDLYS (in isoform 3); 157..233; Missing (in isoform 3)
3D Structural Models
3D Structure
Electron microscopy (1); X-ray crystallography (1)
Clinical Relevance4
Antibody
Interaction Protein
ENSG00000116044
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No abstract available |