Protein detail
DUSTY
Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496)
Entry name DUSTY | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) | Transmembrane count | Protein classification Disease related genesEnzymesHuman disease related genesPotential drug targetsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information10
Protein Names
Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496)
Protein Class (5)
Disease related genesEnzymesHuman disease related genesPotential drug targetsPredicted intracellular proteins
Protein Function (8)
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Human disease related genes:Congenital malformations:Congenital malformations of the urinary system
- Kinases
- Potential drug targets
- Enzymes
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym (5)
DustyPKKIAA0472RIP5RIPK5SPG23
Gene Description
Dual serine/threonine and tyrosine protein kinase
Chromosome
1
Position
205142505-205211702
EVMP confidence score
0.38
Function & Pathway6
Protein Function (8)
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Human disease related genes:Congenital malformations:Congenital malformations of the urinary system
- Kinases
- Potential drug targets
- Enzymes
- Disease related genes
Cellular Component (4)
Molecular Function (6)
Biological Process (3)
Canonical Pathways (3)
- M64 Pid s1p s1p4 pathway
- M103 Pid s1p s1p1 pathway
- M184 Pid ecadherin keratinocyte pathway
Mediation Categories (2)
Fusion and delivery mediationReceptor-signaling mediation
Relations & Evidence11
Ligand-Receptor Signaling (10)
10 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| basolateral_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| apical_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Sequence, Structure & Domains11
Sequences
Length
929
Mass
105,206
Sequence
MEGDGVPWGSEPVSGPGPGGGGMIRELCRGFGRYRRYLGRLRQNLRETQKFFRDIKCSHNHTCLSSLTGGGGAERGPAGDVAETGLQAGQLSCISFPPKEEKYLQQIVDCLPCILILGQDCNVKCQLLNLLLGVQVLPTTKLGSEESCKLRRLRFTYGTQTRVSLALPGQYELVHTLVAHQGNWETIPEEDLEVQENNEDAAHVLAELEVTMHHALLQEVDVVVAPCQGLRPTVDVLGDLVNDFLPVITYALHKDELSERDEQELQEIRKYFSFPVFFFKVPKLGSEIIDSSTRRMESERSPLYRQLIDLGYLSSSHWNCGAPGQDTKAQSMLVEQSEKLRHLSTFSHQVLQTRLVDAAKALNLVHCHCLDIFINQAFDMQRDLQITPKRLEYTRKKENELYESLMNIANRKQEEMKDMIVETLNTMKEELLDDATNMEFKDVIVPENGEPVGTREIKCCIRQIQELIISRLNQAVANKLISSVDYLRESFVGTLERCLQSLEKSQDVSVHITSNYLKQILNAAYHVEVTFHSGSSVTRMLWEQIKQIIQRITWVSPPAITLEWKRKVAQEAIESLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLRVRKDHAPRLARLSLESCSLQDVLLHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGGGSSIAVLLIMERLHRDLYTGLKAGLTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWYICSGSVKLPEAFERCASKDHLWNNVRRGARPERLPVFDEECWQLMEACWDGDPLKRPLLGIVQPMLQGIMNRLCKSNSEQPNRGLDDST
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q6XUX3-1; Sequence=Displayed; Name=2; IsoId=Q6XUX3-2; Sequence=VSP_018034; Name=3; IsoId=Q6XUX3-3; Sequence=VSP_018031; Name=4; IsoId=Q6XUX3-4; Sequence=VSP_018030, VSP_018032, VSP_018033
Alternative Sequence
1..539; Missing (in isoform 4); 451..792; Missing (in isoform 3); 703..718; SLPKHERLVDLHGSVI -> WVLASFISMRKIQRRI (in isoform 4); 719..929; Missing (in isoform 4); 824..868; Missing (in isoform 2)
Domain & Motif Annotations
Compositional Bias
1..14; Low complexity
Coiled Coil
189..215; 395..431
Domain (FT)
652..906; Protein kinase
Region
1..21; Disordered
Protein Families (2)
- Protein kinase superfamily
- Ser/Thr protein kinase family
Sequence Similarities
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Clinical Relevance2
Disease Involvement (3)
Disease variantHereditary spastic paraplegiaNeurodegeneration
Antibody