Protein detail

DUSTY

Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496)

Entry name
DUSTY
UniProt ID
Q6XUX3
EVMP confidence score
0.47
Supporting publications (n)
0
Transmembrane count
Protein classification
Disease related genesEnzymesHuman disease related genesPotential drug targetsPredicted intracellular proteins
Basic Information
Protein Names
Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496)
Protein Class (5)
Disease related genesEnzymesHuman disease related genesPotential drug targetsPredicted intracellular proteins
Protein Function (8)
  • Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
  • Predicted intracellular proteins
  • ENZYME proteins:Transferases
  • Human disease related genes:Congenital malformations:Congenital malformations of the urinary system
  • Kinases
  • Potential drug targets
  • Enzymes
  • Disease related genes
Ensembl
ENSG00000133059
Entrez Gene Symbol
DSTYK
Gene Synonym (5)
DustyPKKIAA0472RIP5RIPK5SPG23
Gene Description
Dual serine/threonine and tyrosine protein kinase
Chromosome
1
Position
205142505-205211702
Supporting publications (n)
0
EVMP confidence score
0.47
Function & Pathway
Protein Function (8)
  • Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
  • Predicted intracellular proteins
  • ENZYME proteins:Transferases
  • Human disease related genes:Congenital malformations:Congenital malformations of the urinary system
  • Kinases
  • Potential drug targets
  • Enzymes
  • Disease related genes
Cellular Component (4)
Molecular Function (6)
Biological Process (3)
Canonical Pathways (3)
  • M64 Pid s1p s1p4 pathway
  • M103 Pid s1p s1p1 pathway
  • M184 Pid ecadherin keratinocyte pathway
Mediation Categories (2)
Fusion and delivery mediationReceptor-signaling mediation
Relations & Evidence11

Ligand-Receptor Signaling (10)

10 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
receptorreceptorOmniPathYes
intracellularintracellularComPPI
intracellularintracellularGO_Intercell
intracellularintracellularUniProt_location
intracellularintracellularOmniPath
plasma_membraneplasma_membraneUniProt_location
basolateral_cell_membraneplasma_membraneUniProt_location
apical_cell_membraneplasma_membraneUniProt_location
plasma_membraneplasma_membraneOmniPath
receptorreceptorscConnectYes

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyMass spectrometry3328543153614683438207106
Sequence, Structure & Domains

Sequences

Length
929
Mass
105,206
Sequence
MEGDGVPWGSEPVSGPGPGGGGMIRELCRGFGRYRRYLGRLRQNLRETQKFFRDIKCSHNHTCLSSLTGGGGAERGPAGDVAETGLQAGQLSCISFPPKEEKYLQQIVDCLPCILILGQDCNVKCQLLNLLLGVQVLPTTKLGSEESCKLRRLRFTYGTQTRVSLALPGQYELVHTLVAHQGNWETIPEEDLEVQENNEDAAHVLAELEVTMHHALLQEVDVVVAPCQGLRPTVDVLGDLVNDFLPVITYALHKDELSERDEQELQEIRKYFSFPVFFFKVPKLGSEIIDSSTRRMESERSPLYRQLIDLGYLSSSHWNCGAPGQDTKAQSMLVEQSEKLRHLSTFSHQVLQTRLVDAAKALNLVHCHCLDIFINQAFDMQRDLQITPKRLEYTRKKENELYESLMNIANRKQEEMKDMIVETLNTMKEELLDDATNMEFKDVIVPENGEPVGTREIKCCIRQIQELIISRLNQAVANKLISSVDYLRESFVGTLERCLQSLEKSQDVSVHITSNYLKQILNAAYHVEVTFHSGSSVTRMLWEQIKQIIQRITWVSPPAITLEWKRKVAQEAIESLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLRVRKDHAPRLARLSLESCSLQDVLLHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGGGSSIAVLLIMERLHRDLYTGLKAGLTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWYICSGSVKLPEAFERCASKDHLWNNVRRGARPERLPVFDEECWQLMEACWDGDPLKRPLLGIVQPMLQGIMNRLCKSNSEQPNRGLDDST
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q6XUX3-1; Sequence=Displayed; Name=2; IsoId=Q6XUX3-2; Sequence=VSP_018034; Name=3; IsoId=Q6XUX3-3; Sequence=VSP_018031; Name=4; IsoId=Q6XUX3-4; Sequence=VSP_018030, VSP_018032, VSP_018033
Alternative Sequence
1..539; Missing (in isoform 4); 451..792; Missing (in isoform 3); 703..718; SLPKHERLVDLHGSVI -> WVLASFISMRKIQRRI (in isoform 4); 719..929; Missing (in isoform 4); 824..868; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias
1..14; Low complexity
Coiled Coil
189..215; 395..431
Domain (FT)
652..906; Protein kinase
Region
1..21; Disordered
Protein Families (2)
  • Protein kinase superfamily
  • Ser/Thr protein kinase family
Sequence Similarities
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Clinical Relevance
Disease Involvement (3)
Disease variantHereditary spastic paraplegiaNeurodegeneration
Related Diseases
Hereditary spastic paraplegia
Antibody
HPA044140