Protein detail

LIPI

Lipase member I (LIPI) (EC 3.1.1.-) (Cancer/testis antigen 17) (CT17) (LPD lipase) (Membrane-associated phosphatidic acid-selective phospholipase A1-beta) (mPA-PLA1 beta)

Entry name LIPI	UniProt ID Q6XZB0	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information6

Protein Names

Lipase member I (LIPI) (EC 3.1.1.-) (Cancer/testis antigen 17) (CT17) (LPD lipase) (Membrane-associated phosphatidic acid-selective phospholipase A1-beta) (mPA-PLA1 beta)

Protein Function

Predicted secreted proteins

Ensembl

ENSG00000188992

Entrez Gene Symbol

LIPI

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization8

Tissue Specificlymphoid tissueCell SpecificEarly spermatidsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificmemory CD4 T-cellBlood Lineage SpecificT-cellsSecretome LocationIntracellular and membraneSecretome FunctionNo annotated function

Function & Pathway7

Protein Function

Predicted secreted proteins

Cellular Component (2)

Molecular Function (2)

Biological Process (3)

Reactome (4)

Canonical Pathways (3)

M120 Pid arf6 downstream pathway
M252 Pid il8 cxcr1 pathway
M275 Pid alpha synuclein pathway

Mediation Categories

Metabolism mediation

Relations & Evidence9

Ligand-Receptor Signaling (8)

8 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	MatrixDB	Yes	No	Yes	No	No
ecm	ecm	OmniPath	Yes	No	Yes	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	Yes	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	Yes	No	No
secreted	secreted	UniProt_keyword	No	No	Yes	No	No
secreted	secreted	UniProt_location	No	No	Yes	No	No
secreted	secreted	HPA_secretome	No	No	Yes	No	No
secreted	secreted	OmniPath	No	No	Yes	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	5	38225453 26801919 33709510 36635400 37922300

Sequence, Structure & Domains7

Sequences

Length

460

Mass

52,922

Sequence

MRVYIFLCLMCWVRSDNKRPCLEFSQLSVKDSFRDLFIPRIETILMMYTRNNLNCAEPLFEQNNSLNVNFNTQKKTVWLIHGYRPVGSIPLWLQNFVRILLNEEDMNVIVVDWSRGATTFIYNRAVKNTRKVAVSLSVHIKNLLKHGASLDNFHFIGVSLGAHISGFVGKIFHGQLGRITGLDPAGPRFSRKPPYSRLDYTDAKFVDVIHSDSNGLGIQEPLGHIDFYPNGGNKQPGCPKSIFSGIQFIKCNHQRAVHLFMASLETNCNFISFPCRSYKDYKTSLCVDCDCFKEKSCPRLGYQAKLFKGVLKERMEGRPLRTTVFLDTSGTYPFCTYYFVLSIIVPDKTMMDGSFSFKLLNQLGMIEEPRLYEKNKPFYKLQEVKILAQFYNDFVNISSIGLTYFQSSNLQCSTCTYKIQSLMLKSLTYPERPPLCRYNIVLKDREEVFLNPNTCTPKNT

Alternative Products

Event=Alternative splicing; Named isoforms=8; Name=1; Synonyms=mPA-PLA1beta; IsoId=Q6XZB0-1; Sequence=Displayed; Name=2; Synonyms=mPA-PLA1alpha; IsoId=Q6XZB0-2; Sequence=VSP_016090; Name=3; Synonyms=deltaE7.2; IsoId=Q6XZB0-3; Sequence=VSP_053899; Name=4; Synonyms=deltaE6.1; IsoId=Q6XZB0-4; Sequence=VSP_053898; Name=5; Synonyms=deltaE5; IsoId=Q6XZB0-5; Sequence=VSP_053897; Name=6; Synonyms=deltaE8-9; IsoId=Q6XZB0-6; Sequence=VSP_053900, VSP_053903; Name=7; Synonyms=7B+; IsoId=Q6XZB0-7; Sequence=VSP_053901, VSP_053902; Name=8; Synonyms=deltaE2-3; IsoId=Q6XZB0-8; Sequence=VSP_053896

Alternative Sequence

1..13; MRVYIFLCLMCWV -> MLLKCLHNNLCQKYSAHAFQFSPRNVLWLLVVCL (in isoform 2); 16..180; Missing (in isoform 8); 215..244; Missing (in isoform 5); 245..279; Missing (in isoform 4); 330..336; GTYPFCT -> A (in isoform 3); 336..375; TYYFVLSIIVPDKTMMDGSFSFKLLNQLGMIEEPRLYEKN -> NHHFAGIILYLKNERKCFLIQTHVHQRTHKMPSSIKCTCL (in isoform 6); 336..368; TYYFVLSIIVPDKTMMDGSFSFKLLNQLGMIEE -> NKPVFRIYLFNTSPYPLLAGRLFHLSCLRVVKN (in isoform 7); 369..460; Missing (in isoform 7); 376..460; Missing (in isoform 6)

Domain & Motif Annotations

Protein Families (2)

AB hydrolase superfamily
Lipase family

Sequence Similarities

Belongs to the AB hydrolase superfamily. Lipase family.

Supporting Publications1

PMID	Title	Abstract
26801919	Exosomes Secreted by Apoptosis-Resistant Acute Myeloid Leukemia (AML) Blasts Harbor Regulatory Network Proteins Potentially Involved in Antagonism of Apoptosis.	No abstract available