Protein detail
S36A4
Neutral amino acid uniporter 4 (Solute carrier family 36 member 4)
Protein symbol S36A4 | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 10 | Protein classification Metabolic proteinsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Neutral amino acid uniporter 4 (Solute carrier family 36 member 4)
Protein Class
Metabolic proteinsPredicted membrane proteinsTransporters
Protein Function
Transporters:Electrochemical Potential-driven transporters
Transmembrane
87..107; Helical; 154..174; Helical; 206..226; Helical; 231..251; Helical; 273..293; Helical; 309..329; Helical; 358..378; Helical; 389..409; Helical; 414..434; Helical; 456..476; Helical
Transmembrane Count
10
Ensembl
Entrez Gene Symbol
Gene Synonym
FLJ38932PAT4
Gene Description
Solute carrier family 36 member 4
Chromosome
11
Position
93144174-93197991
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificintestineCell SpecificEnterocytesSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificnon-classical monocyteBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function
Transporters:Electrochemical Potential-driven transporters
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
19 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transporter | transporter | Surfaceome | No | Yes | No | No | No |
| solute_carrier | transporter | Almen2009 | No | Yes | No | No | No |
| slc36 | transporter | Surfaceome | No | Yes | No | No | No |
| apc | transporter | Surfaceome | No | Yes | No | No | No |
| slc | transporter | Surfaceome | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
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Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| RAB12 | Q6IQ22 | S36A4 | Q6YBV0 | Yes | No | Yes | SIGNOR | SIGNOR:23478338 |
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
504
Mass
56,157
Sequence
MEAAATPAAAGAARREELDMDVMRPLINEQNFDGTSDEEHEQELLPVQKHYQLDDQEGISFVQTLMHLLKGNIGTGLLGLPLAIKNAGIVLGPISLVFIGIISVHCMHILVRCSHFLCLRFKKSTLGYSDTVSFAMEVSPWSCLQKQAAWGRSVVDFFLVITQLGFCSVYIVFLAENVKQVHEGFLESKVFISNSTNSSNPCERRSVDLRIYMLCFLPFIILLVFIRELKNLFVLSFLANVSMAVSLVIIYQYVVRNMPDPHNLPIVAGWKKYPLFFGTAVFAFEGIGVVLPLENQMKESKRFPQALNIGMGIVTTLYVTLATLGYMCFHDEIKGSITLNLPQDVWLYQSVKILYSFGIFVTYSIQFYVPAEIIIPGITSKFHTKWKQICEFGIRSFLVSITCAGAILIPRLDIVISFVGAVSSSTLALILPPLVEILTFSKEHYNIWMVLKNISIAFTGVVGFLLGTYITVEEIIYPTPKVVAGTPQSPFLNLNSTCLTSGLK
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6YBV0-1; Sequence=Displayed; Name=2; IsoId=Q6YBV0-2; Sequence=VSP_028959
Alternative Sequence
1..135; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Protein Families
Amino acid/polyamine transporter 2 family
Sequence Similarities
Belongs to the amino acid/polyamine transporter 2 family.
Clinical Relevance
Antibody