Protein detail

CD109

CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109)

Entry name CD109	UniProt ID Q6YHK3	EVMP confidence score 0.88
Supporting publications (n) 28	Transmembrane count	Protein classification CD markersPlasma proteinsPredicted membrane proteins

Basic Information

Protein Names

CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109)

Protein Class (3)

CD markersPlasma proteinsPredicted membrane proteins

Protein Function

CD markers

Ensembl

ENSG00000156535

Entrez Gene Symbol

CD109

Gene Synonym (3)

CPAMD7DKFZp762L1111FLJ38569

Gene Description

CD109 molecule

Chromosome

Position

73695785-73828316

Supporting publications (n)

EVMP confidence score

0.88

Fluorescence & Localization

Function & Pathway

Protein Function

CD markers

Cellular Component (7)

Molecular Function

GO:0004867 serine-type endopeptidase inhibitor activity

Biological Process (3)

Reactome (5)

Mediation Categories (3)

Fusion and delivery mediationImmune mediationMetabolism mediation

Relations & Evidence22

Ligand-Receptor Signaling (17)

17 records.

Category	Parent	Database	Receiver	Plasma Membrane (Peripheral)
plasma_membrane_peripheral	plasma_membrane_peripheral	CSPA		Yes
plasma_membrane_peripheral	plasma_membrane_peripheral	OmniPath		Yes
cell_surface	cell_surface	Surfaceome		Yes
cell_surface	cell_surface	OmniPath		Yes
receptor	receptor	iTALK	Yes	Yes
growth_factor	receptor	iTALK	Yes	Yes
receptor	receptor	EMBRACE	Yes	Yes

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Protein Complex Composition (4)

4 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HT_DM_Cluster185	CD109 TXNL4A TXNL4B	P83876 Q6YHK3 Q9NX01	1:1:1	Compleat	Compleat:HC158	22036573
	ACADVL APEH CAPN1 CD109 LMNB2	P07384 P13798 P49748 Q03252 Q6YHK3	0:0:0:0:0	hu.MAP2
	CD109 COA7	Q6YHK3 Q96BR5	0:0	hu.MAP
	CD109 SAT2	Q6YHK3 Q96F10	0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration	Mass spectrometry	1	37427430

Sequence, Structure & Domains

Sequences

Length

1,445

Mass

161,689

Sequence

MQGPPLLTAAHLLCVCTAALAVAPGPRFLVTAPGIIRPGGNVTIGVELLEHCPSQVTVKAELLKTASNLTVSVLEAEGVFEKGSFKTLTLPSLPLNSADEIYELRVTGRTQDEILFSNSTRLSFETKRISVFIQTDKALYKPKQEVKFRIVTLFSDFKPYKTSLNILIKDPKSNLIQQWLSQQSDLGVISKTFQLSSHPILGDWSIQVQVNDQTYYQSFQVSEYVLPKFEVTLQTPLYCSMNSKHLNGTITAKYTYGKPVKGDVTLTFLPLSFWGKKKNITKTFKINGSANFSFNDEEMKNVMDSSNGLSEYLDLSSPGPVEILTTVTESVTGISRNVSTNVFFKQHDYIIEFFDYTTVLKPSLNFTATVKVTRADGNQLTLEERRNNVVITVTQRNYTEYWSGSNSGNQKMEAVQKINYTVPQSGTFKIEFPILEDSSELQLKAYFLGSKSSMAVHSLFKSPSKTYIQLKTRDENIKVGSPFELVVSGNKRLKELSYMVVSRGQLVAVGKQNSTMFSLTPENSWTPKACVIVYYIEDDGEIISDVLKIPVQLVFKNKIKLYWSKVKAEPSEKVSLRISVTQPDSIVGIVAVDKSVNLMNASNDITMENVVHELELYNTGYYLGMFMNSFAVFQECGLWVLTDANLTKDYIDGVYDNAEYAERFMEENEGHIVDIHDFSLGSSPHVRKHFPETWIWLDTNMGYRIYQEFEVTVPDSITSWVATGFVISEDLGLGLTTTPVELQAFQPFFIFLNLPYSVIRGEEFALEITIFNYLKDATEVKVIIEKSDKFDILMTSNEINATGHQQTLLVPSEDGATVLFPIRPTHLGEIPITVTALSPTASDAVTQMILVKAEGIEKSYSQSILLDLTDNRLQSTLKTLSFSFPPNTVTGSERVQITAIGDVLGPSINGLASLIRMPYGCGEQNMINFAPNIYILDYLTKKKQLTDNLKEKALSFMRQGYQRELLYQREDGSFSAFGNYDPSGSTWLSAFVLRCFLEADPYIDIDQNVLHRTYTWLKGHQKSNGEFWDPGRVIHSELQGGNKSPVTLTAYIVTSLLGYRKYQPNIDVQESIHFLESEFSRGISDNYTLALITYALSSVGSPKAKEALNMLTWRAEQEGGMQFWVSSESKLSDSWQPRSLDIEVAAYALLSHFLQFQTSEGIPIMRWLSRQRNSLGGFASTQDTTVALKALSEFAALMNTERTNIQVTVTGPSSPSPVKFLIDTHNRLLLQTAELAVVQPTAVNISANGFGFAICQLNVVYNVKASGSSRRRRSIQNQEAFDLDVAVKENKDDLNHVDLNVCTSFSGPGRSGMALMEVNLLSGFMVPSEAISLSETVKKVEYDHGKLNLYLDSVNETQFCVNIPAVRNFKVSNTQDASVSIVDYYEPRRQAVRSYNSEVKLSSCDLCSDVQGCRPCEDGASGSHHHSSVIFIFCFKLLYFMELWL

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=CD109 180-kDa; IsoId=Q6YHK3-1; Sequence=Displayed; Name=2; IsoId=Q6YHK3-2; Sequence=VSP_021312; Name=3; IsoId=Q6YHK3-3; Sequence=VSP_021313, VSP_021314; Name=4; Synonyms=CD109S; IsoId=Q6YHK3-4; Sequence=VSP_021315

Alternative Sequence

93..169; Missing (in isoform 2); 658..665; AEYAERFM -> LFGTQEAL (in isoform 3); 666..1445; Missing (in isoform 3); 1218..1234; Missing (in isoform 4)

3D Structural Models

3D Structure

Electron microscopy (3)

Domain & Motif Annotations

Region

593..702; Bait region (approximate)

Protein Families

Protease inhibitor I39 (alpha-2-macroglobulin) family

Sequence Similarities

Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.

Clinical Relevance

Antibody (2)

HPA008992 HPA015723

Supporting Publications28

PMID	Title	Related sentences
38772652	High-throughput proteomic analysis of extracellular vesicles from saliva by chemical probe-based array.	No related sentences available
38895962	A fast and sensitive size-exclusion chromatography method for plasma extracellular vesicle proteomic analysis.	No related sentences available
39207047	The trajectory of vesicular proteomic signatures from HBV-HCC by chitosan-magnetic bead-based separation and DIA-proteomic analysis.	No related sentences available
40189497	Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis.	No related sentences available
40465195	Extracellular vesicle proteomics uncovers energy metabolism, complement system, and endoplasmic reticulum stress response dysregulation postexercise in males with myalgic encephalomyelitis/chronic fatigue syndrome.	No related sentences available
40840701	Multiomics analysis to evaluate the enrichment of extracellular vesicles from human plasma.	No related sentences available
41068253	Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression.	No related sentences available
41307968	Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System.	No related sentences available

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