Protein detail
CD109
CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109)
Entry name CD109 | UniProt ID | EVMP confidence score 0.88 |
Supporting publications (n) 29 | Transmembrane count | Protein classification CD markersPlasma proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109)
Protein Class (3)
CD markersPlasma proteinsPredicted membrane proteins
Protein Function
CD markers
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
CPAMD7DKFZp762L1111FLJ38569
Gene Description
CD109 molecule
Chromosome
6
Position
73695785-73828316
Supporting publications (n)
29
EVMP confidence score
0.88
Fluorescence & Localization1
Function & Pathway6
Protein Function
CD markers
Cellular Component (7)
Molecular Function
Biological Process (3)
Reactome (5)
Mediation Categories (3)
Fusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence22
Ligand-Receptor Signaling (17)
17 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane_peripheral | plasma_membrane_peripheral | CSPA | No | No | No | No | Yes |
| plasma_membrane_peripheral | plasma_membrane_peripheral | OmniPath | No | No | No | No | Yes |
| cell_surface | cell_surface | Surfaceome | No | No | No | No | Yes |
| cell_surface | cell_surface | OmniPath | No | No | No | No | Yes |
| receptor | receptor | iTALK | No | Yes | No | No | Yes |
| growth_factor | receptor | iTALK | No | Yes | No | No | Yes |
| receptor | receptor | EMBRACE | No | Yes | No | No | Yes |
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Protein Complex Composition (4)
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| HT_DM_Cluster185 | CD109TXNL4ATXNL4B | P83876Q6YHK3Q9NX01 | 1:1:1 | Compleat | Compleat:HC158 | 22036573 |
| ACADVLAPEHCAPN1CD109LMNB2 | P07384P13798P49748Q03252Q6YHK3 | 0:0:0:0:0 | hu.MAP2 | |||
| CD109COA7 | Q6YHK3Q96BR5 | 0:0 | hu.MAP | |||
| CD109SAT2 | Q6YHK3Q96F10 | 0:0 | hu.MAP |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration | Mass spectrometry | 1 | 37427430 |
Sequence, Structure & Domains9
Sequences
Length
1,445
Mass
161,689
Sequence
MQGPPLLTAAHLLCVCTAALAVAPGPRFLVTAPGIIRPGGNVTIGVELLEHCPSQVTVKAELLKTASNLTVSVLEAEGVFEKGSFKTLTLPSLPLNSADEIYELRVTGRTQDEILFSNSTRLSFETKRISVFIQTDKALYKPKQEVKFRIVTLFSDFKPYKTSLNILIKDPKSNLIQQWLSQQSDLGVISKTFQLSSHPILGDWSIQVQVNDQTYYQSFQVSEYVLPKFEVTLQTPLYCSMNSKHLNGTITAKYTYGKPVKGDVTLTFLPLSFWGKKKNITKTFKINGSANFSFNDEEMKNVMDSSNGLSEYLDLSSPGPVEILTTVTESVTGISRNVSTNVFFKQHDYIIEFFDYTTVLKPSLNFTATVKVTRADGNQLTLEERRNNVVITVTQRNYTEYWSGSNSGNQKMEAVQKINYTVPQSGTFKIEFPILEDSSELQLKAYFLGSKSSMAVHSLFKSPSKTYIQLKTRDENIKVGSPFELVVSGNKRLKELSYMVVSRGQLVAVGKQNSTMFSLTPENSWTPKACVIVYYIEDDGEIISDVLKIPVQLVFKNKIKLYWSKVKAEPSEKVSLRISVTQPDSIVGIVAVDKSVNLMNASNDITMENVVHELELYNTGYYLGMFMNSFAVFQECGLWVLTDANLTKDYIDGVYDNAEYAERFMEENEGHIVDIHDFSLGSSPHVRKHFPETWIWLDTNMGYRIYQEFEVTVPDSITSWVATGFVISEDLGLGLTTTPVELQAFQPFFIFLNLPYSVIRGEEFALEITIFNYLKDATEVKVIIEKSDKFDILMTSNEINATGHQQTLLVPSEDGATVLFPIRPTHLGEIPITVTALSPTASDAVTQMILVKAEGIEKSYSQSILLDLTDNRLQSTLKTLSFSFPPNTVTGSERVQITAIGDVLGPSINGLASLIRMPYGCGEQNMINFAPNIYILDYLTKKKQLTDNLKEKALSFMRQGYQRELLYQREDGSFSAFGNYDPSGSTWLSAFVLRCFLEADPYIDIDQNVLHRTYTWLKGHQKSNGEFWDPGRVIHSELQGGNKSPVTLTAYIVTSLLGYRKYQPNIDVQESIHFLESEFSRGISDNYTLALITYALSSVGSPKAKEALNMLTWRAEQEGGMQFWVSSESKLSDSWQPRSLDIEVAAYALLSHFLQFQTSEGIPIMRWLSRQRNSLGGFASTQDTTVALKALSEFAALMNTERTNIQVTVTGPSSPSPVKFLIDTHNRLLLQTAELAVVQPTAVNISANGFGFAICQLNVVYNVKASGSSRRRRSIQNQEAFDLDVAVKENKDDLNHVDLNVCTSFSGPGRSGMALMEVNLLSGFMVPSEAISLSETVKKVEYDHGKLNLYLDSVNETQFCVNIPAVRNFKVSNTQDASVSIVDYYEPRRQAVRSYNSEVKLSSCDLCSDVQGCRPCEDGASGSHHHSSVIFIFCFKLLYFMELWL
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=CD109 180-kDa; IsoId=Q6YHK3-1; Sequence=Displayed; Name=2; IsoId=Q6YHK3-2; Sequence=VSP_021312; Name=3; IsoId=Q6YHK3-3; Sequence=VSP_021313, VSP_021314; Name=4; Synonyms=CD109S; IsoId=Q6YHK3-4; Sequence=VSP_021315
Alternative Sequence
93..169; Missing (in isoform 2); 658..665; AEYAERFM -> LFGTQEAL (in isoform 3); 666..1445; Missing (in isoform 3); 1218..1234; Missing (in isoform 4)
3D Structural Models
3D Structure
Electron microscopy (3)
Domain & Motif Annotations
Region
593..702; Bait region (approximate)
Protein Families
Protease inhibitor I39 (alpha-2-macroglobulin) family
Sequence Similarities
Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
Supporting Publications28
| PMID | Title | Abstract |
|---|---|---|
| 38772652 | High-throughput proteomic analysis of extracellular vesicles from saliva by chemical probe-based array. | No abstract available |
| 38895962 | A fast and sensitive size-exclusion chromatography method for plasma extracellular vesicle proteomic analysis. | No abstract available |
| 39207047 | The trajectory of vesicular proteomic signatures from HBV-HCC by chitosan-magnetic bead-based separation and DIA-proteomic analysis. | No abstract available |
| 40189497 | Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis. | No abstract available |
| 40465195 | Extracellular vesicle proteomics uncovers energy metabolism, complement system, and endoplasmic reticulum stress response dysregulation postexercise in males with myalgic encephalomyelitis/chronic fatigue syndrome. | No abstract available |
| 40840701 | Multiomics analysis to evaluate the enrichment of extracellular vesicles from human plasma. | No abstract available |
| 41068253 | Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression. | No abstract available |
| 41307968 | Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System. | No abstract available |
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