Protein detail

GLDN

Gliomedin [Cleaved into: Gliomedin shedded ectodomain]

Entry name GLDN	UniProt ID Q6ZMI3	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count 1	Protein classification Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted secreted proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Gliomedin [Cleaved into: Gliomedin shedded ectodomain]

Protein Class (4)

Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted secreted proteins

Protein Function (4)

Disease related genes
Predicted secreted proteins
Predicted intracellular proteins
Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system

Transmembrane

18..39; Helical; Signal-anchor for type II membrane protein

Transmembrane Count

Ensembl

ENSG00000186417

Entrez Gene Symbol

GLDN

Gene Synonym (5)

CLOMCOLMcolmedinCRG-L2UNC-122

Gene Description

Gliomedin

Chromosome

Position

51341655-51408005

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization3

Secretome LocationSecreted to bloodSecretome FunctionOther

Function & Pathway6

Protein Function (4)

Disease related genes
Predicted secreted proteins
Predicted intracellular proteins
Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system

Cellular Component (5)

Molecular Function

GO:0086080 protein binding involved in heterotypic cell-cell adhesion

Biological Process (3)

KEGG

hsa04517 IgSF CAM signaling

Mediation Categories

Other mediation

Relations & Evidence17

Ligand-Receptor Signaling (14)

14 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
secreted	secreted	OmniPath	No	No	Yes	No	No
cell_surface	cell_surface	Surfaceome	No	No	Yes	No	No
cell_surface	cell_surface	OmniPath	No	No	Yes	No	No
glycoprotein	ecm	Matrisome	Yes	No	Yes	No	No

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
GLDN	Q6ZMI3	ANK3	Q12955	Yes	Yes	No	SIGNOR	SIGNOR:19840192

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	DCP1A DCP1B DCP2 DDX6 EDC3 EDC4 GLDN MARF1 PIM1 PNRC1 PPP1R35	P11309 P26196 Q12796 Q6P2E9 Q6ZMI3 Q8IU60 Q8IZD4 Q8TAP8 Q96F86 Q9NPI6 Q9Y4F3	0:0:0:0:0:0:0:0:0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometryFlow cytometryMORPH	4	32854315 37563857 31805958 38207106

Sequence, Structure & Domains13

Sequences

Length

551

Mass

58,957

Sequence

MARGAEGGRGDAGWGLRGALAAVALLSALNAAGTVFALCQWRGLSSALRALEAQRGREQREDSALRSFLAELSRAPRGASAPPQDPASSARNKRSHSGEPAPHIRAESHDMLMMMTYSMVPIRVMVDLCNSTKGICLTGPSGPPGPPGAGGLPGHNGLDGQPGPQGPKGEKGANGKRGKMGIPGAAGNPGERGEKGDHGELGLQGNEGPPGQKGEKGDKGDVSNDVLLAGAKGDQGPPGPPGPPGPPGPPGPPGSRRAKGPRQPSMFNGQCPGETCAIPNDDTLVGKADEKASEHHSPQAESMITSIGNPVQVLKVTETFGTWIRESANKSDDRIWVTEHFSGIMVKEFKDQPSLLNGSYTFIHLPYYFHGCGHVVYNNSLYYHKGGSNTLVRFEFGQETSQTLKLENALYFDRKYLFANSKTYFNLAVDEKGLWIIYASSVDGSSILVAQLDERTFSVVQHVNTTYPKSKAGNAFIARGILYVTDTKDMRVTFAFDLLGGKQINANFDLRTSQSVLAMLAYNMRDQHLYSWEDGHLMLYPVQFLSTTLNQ

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6ZMI3-1; Sequence=Displayed; Name=2; IsoId=Q6ZMI3-2; Sequence=VSP_019845

Alternative Sequence

1..124; Missing (in isoform 2)

3D Structural Models

Turn

396..398; 441..443; 454..456; 498..501; 524..527

Helix

352..357; 419..421; 469..471

Beta Strand

303..307; 311..315; 319..325; 328..330; 335..351; 361..372; 375..377; 380..385; 388..395; 401..405; 426..430; 433..440; 446..452; 459..468; 475..478; 481..485; 489..497; 502..504; 517..523; 528..533; 536..545

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

79..90; Low complexity; 191..200; Basic and acidic residues; 213..222; Basic and acidic residues; 237..253; Pro residues

Domain (CC)

The olfactomedin-like domain mediates NFASC/neurofascin and NRCAM binding.

Domain (FT)

137..195; Collagen-like 1; 196..222; Collagen-like 2; 299..546; Olfactomedin-like

Region

72..107; Disordered; 139..282; Disordered

Clinical Relevance2

Disease Involvement

Disease variant

Antibody (2)

HPA050873 HPA059441

Supporting Publications1

PMID	Title	Abstract
38716512	Assessment of urine sample collection and processing variables for extracellular vesicle-based proteomics.	No abstract available