Protein detail
GLDN
Gliomedin [Cleaved into: Gliomedin shedded ectodomain]
Protein symbol GLDN | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count 1 | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted secreted proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Gliomedin [Cleaved into: Gliomedin shedded ectodomain]
Protein Class
Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted secreted proteins
Protein Function
- Disease related genes
- Predicted secreted proteins
- Predicted intracellular proteins
- Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
Transmembrane
18..39; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CLOMCOLMcolmedinCRG-L2UNC-122
Gene Description
Gliomedin
Chromosome
15
Position
51341655-51408005
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Secretome LocationSecreted to bloodSecretome FunctionOther
Function & Pathway
Protein Function
- Disease related genes
- Predicted secreted proteins
- Predicted intracellular proteins
- Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Other mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
14 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| secreted | secreted | OmniPath | No | No | Yes | No | No |
| cell_surface | cell_surface | Surfaceome | No | No | Yes | No | No |
| cell_surface | cell_surface | OmniPath | No | No | Yes | No | No |
| glycoprotein | ecm | Matrisome | Yes | No | Yes | No | No |
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Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| GLDN | Q6ZMI3 | ANK3 | Q12955 | Yes | Yes | No | SIGNOR | SIGNOR:19840192 |
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
551
Mass
58,957
Sequence
MARGAEGGRGDAGWGLRGALAAVALLSALNAAGTVFALCQWRGLSSALRALEAQRGREQREDSALRSFLAELSRAPRGASAPPQDPASSARNKRSHSGEPAPHIRAESHDMLMMMTYSMVPIRVMVDLCNSTKGICLTGPSGPPGPPGAGGLPGHNGLDGQPGPQGPKGEKGANGKRGKMGIPGAAGNPGERGEKGDHGELGLQGNEGPPGQKGEKGDKGDVSNDVLLAGAKGDQGPPGPPGPPGPPGPPGPPGSRRAKGPRQPSMFNGQCPGETCAIPNDDTLVGKADEKASEHHSPQAESMITSIGNPVQVLKVTETFGTWIRESANKSDDRIWVTEHFSGIMVKEFKDQPSLLNGSYTFIHLPYYFHGCGHVVYNNSLYYHKGGSNTLVRFEFGQETSQTLKLENALYFDRKYLFANSKTYFNLAVDEKGLWIIYASSVDGSSILVAQLDERTFSVVQHVNTTYPKSKAGNAFIARGILYVTDTKDMRVTFAFDLLGGKQINANFDLRTSQSVLAMLAYNMRDQHLYSWEDGHLMLYPVQFLSTTLNQ
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6ZMI3-1; Sequence=Displayed; Name=2; IsoId=Q6ZMI3-2; Sequence=VSP_019845
Alternative Sequence
1..124; Missing (in isoform 2)
3D Structural Models
Turn
396..398; 441..443; 454..456; 498..501; 524..527
Helix
352..357; 419..421; 469..471
Beta Strand
303..307; 311..315; 319..325; 328..330; 335..351; 361..372; 375..377; 380..385; 388..395; 401..405; 426..430; 433..440; 446..452; 459..468; 475..478; 481..485; 489..497; 502..504; 517..523; 528..533; 536..545
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
79..90; Low complexity; 191..200; Basic and acidic residues; 213..222; Basic and acidic residues; 237..253; Pro residues
Domain (CC)
The olfactomedin-like domain mediates NFASC/neurofascin and NRCAM binding.
Domain (FT)
137..195; Collagen-like 1; 196..222; Collagen-like 2; 299..546; Olfactomedin-like
Region
72..107; Disordered; 139..282; Disordered