Protein detail

SCAR5

Scavenger receptor class A member 5 (Scavenger receptor hlg)

Entry name SCAR5	UniProt ID Q6ZMJ2	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 1	Protein classification Predicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Scavenger receptor class A member 5 (Scavenger receptor hlg)

Protein Class (2)

Predicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins

Transmembrane

61..81; Helical; Signal-anchor for type II membrane protein

Transmembrane Count

Ensembl

ENSG00000168079

Entrez Gene Symbol

SCARA5

Gene Synonym (3)

FLJ23907MGC45780NET33

Gene Description

Scavenger receptor class A member 5

Chromosome

Position

27869883-27992673

Supporting publications (n)

EVMP confidence score

0.25

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (2)

Molecular Function (2)

Biological Process (3)

Reactome (3)

Mediation Categories

Fusion and delivery mediation

Relations & Evidence27

Ligand-Receptor Signaling (25)

25 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	HGNC	No	Yes	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No
transmembrane_phobius	transmembrane_predicted	Almen2009	No	No	No	Yes	No
transmembrane_sosui	transmembrane_predicted	Almen2009	No	No	No	Yes	No
transmembrane_tmhmm	transmembrane_predicted	Almen2009	No	No	No	Yes	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	HS3ST2 NRM SCARA5	Q6ZMJ2 Q8IXM6 Q9Y278	0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	2	32854315 40730843

Sequence, Structure & Domains14

Sequences

Length

495

Mass

53,994

Sequence

MENKAMYLHTVSDCDTSSICEDSFDGRSLSKLNLCEDGPCHKRRASICCTQLGSLSALKHAVLGLYLLVFLILVGIFILAVSRPRSSPDDLKALTRNVNRLNESFRDLQLRLLQAPLQADLTEQVWKVQDALQNQSDSLLALAGAVQRLEGALWGLQAQAVQTEQAVALLRDRTGQQSDTAQLELYQLQVESNSSQLLLRRHAGLLDGLARRVGILGEELADVGGVLRGLNHSLSYDVALHRTRLQDLRVLVSNASEDTRRLRLAHVGMELQLKQELAMLNAVTEDLRLKDWEHSIALRNISLAKGPPGPKGDQGDEGKEGRPGIPGLPGLRGLPGERGTPGLPGPKGDDGKLGATGPMGMRGFKGDRGPKGEKGEKGDRAGDASGVEAPMMIRLVNGSGPHEGRVEVYHDRRWGTVCDDGWDKKDGDVVCRMLGFRGVEEVYRTARFGQGTGRIWMDDVACKGTEETIFRCSFSKWGVTNCGHAEDASVTCNRH

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q6ZMJ2-1; Sequence=Displayed; Name=2; IsoId=Q6ZMJ2-2; Sequence=VSP_023474, VSP_023475; Name=3; IsoId=Q6ZMJ2-3; Sequence=VSP_023472, VSP_023474, VSP_023475; Name=4; IsoId=Q6ZMJ2-4; Sequence=VSP_023473

Alternative Sequence

38..80; Missing (in isoform 3); 81..305; Missing (in isoform 4); 386..400; GVEAPMMIRLVNGSG -> KDILLGPWDMVLAQG (in isoform 2 and isoform 3); 401..495; Missing (in isoform 2 and isoform 3)

3D Structural Models

Helix

424..433; 469..471; 484..486

Beta Strand

393..400; 403..410; 413..418; 437..443; 455..457; 489..493

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

313..322; Basic and acidic residues; 323..341; Low complexity; 364..382; Basic and acidic residues

Coiled Coil

91..111

Domain (FT)

305..357; Collagen-like; 393..493; SRCR

Region

301..386; Disordered

Protein Families

SCARA5 family

Sequence Similarities

Belongs to the SCARA5 family.

Clinical Relevance1

Antibody

HPA024661

Supporting Publications1

PMID	Title	Abstract
39247822	Exosomal SLC16A1-AS1-induced M2 macrophages polarization facilitates hepatocellular carcinoma progression.	We found that HCC exosomes-derived antisense RNA of SLC16A1(SLC16A1-AS1) promoted the malignant progression of HCC by regulating macrophage M2-type polarization.