Protein detail
UNC5A
Netrin receptor UNC5A (Protein unc-5 homolog 1) (Protein unc-5 homolog A)
Entry name UNC5A | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information7
Protein Names
Netrin receptor UNC5A (Protein unc-5 homolog 1) (Protein unc-5 homolog A)
Transmembrane
307..327; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization3
Tissue SpecificintestineCell SpecificProximal tubule cells
Function & Pathway7
Cellular Component (4)
Molecular Function
Biological Process (3)
Reactome (7)
- R-hsa-109581 apoptosis
- R-hsa-418889 caspase activation via dependence receptors in the absence of ligand
- R-hsa-5357769 caspase activation via extrinsic apoptotic signalling pathway
- R-hsa-9675108 nervous system development
- R-hsa-373752 netrin 1 signaling
- R-hsa-418886 netrin mediated repulsion signals
- R-hsa-5357801 programmed cell death
Canonical Pathways (2)
- M7 Pid fcer1 pathway
- M19 Pid p73pathway
Mediation Categories
Fusion and delivery mediation
Relations & Evidence63
Enzyme-Mediated Modification (2)
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| UNC5A | PRKCA | P17252 | S | 532 | phosphorylation | SIGNOR | SIGNOR:16554470 |
| UNC5A | PRKCA | P17252 | S | 352 | phosphorylation | SIGNOR | SIGNOR:16554470 |
Ligand-Receptor Signaling (56)
56 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | No | Yes | No | Yes | No |
| receptor | receptor | HPMR | No | Yes | No | Yes | No |
| receptor | receptor | CellChatDB | No | Yes | No | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | No | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | No | Yes | No |
| receptor | receptor | Ramilowski2015 | No | Yes | No | Yes | No |
| receptor | receptor | LRdb | No | Yes | No | Yes | No |
| ig_like | receptor | Almen2009 | No | Yes | No | Yes | No |
| netrin | receptor | Almen2009 | No | Yes | No | Yes | No |
| netrin | receptor | HPMR | No | Yes | No | Yes | No |
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Regulatory Interaction Network (4)
4 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KPCA | P17252 | UNC5A | Q6ZN44 | Yes | No | Yes | SIGNOR_ProtMapperSIGNORProtMapper | ProtMapper:16554470SIGNOR:16554470 |
| UNC5A | Q6ZN44 | PICK1 | Q9NRD5 | Yes | Yes | No | SIGNOR | SIGNOR:16554470 |
| UNC5A | Q6ZN44 | DCC | P43146 | Yes | No | Yes | SIGNOR | SIGNOR:25881791 |
| NET4 | Q9HB63 | UNC5A | Q6ZN44 | Yes | Yes | No | Fantom5_LRdbCellTalkDBHPMR_LRdbiTALKHPMR_CellinkertalklrRamilowski2015SIGNORconnectomeDB2020CellinkerWangLRdbHPMR_talklr | LRdb:17174565Cellinker:17174565SIGNOR:12598531CellTalkDB:17174565connectomeDB2020:17174565 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 39363010 |
Sequence, Structure & Domains14
Sequences
Length
842
Mass
92,932
Sequence
MAVRPGLWPALLGIVLAAWLRGSGAQQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKPVLLVCKAVPATQIFFKCNGEWVRQVDHVIERSTDGSSGLPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAKNIVARRRSASAAVIVYVDGSWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDLDTRNCTSDLCVHTASGPEDVALYVGLIAVAVCLVLLLLVLILVYCRKKEGLDSDVADSSILTSGFQPVSIKPSKADNPHLLTIQPDLSTTTTTYQGSLCPRQDGPSPKFQLTNGHLLSPLGGGRHTLHHSSPTSEAEEFVSRLSTQNYFRSLPRGTSNMTYGTFNFLGGRLMIPNTGISLLIPPDAIPRGKIYEIYLTLHKPEDVRLPLAGCQTLLSPIVSCGPPGVLLTRPVILAMDHCGEPSPDSWSLRLKKQSCEGSWEDVLHLGEEAPSHLYYCQLEASACYVFTEQLGRFALVGEALSVAAAKRLKLLLFAPVACTSLEYNIRVYCLHDTHDALKEVVQLEKQLGGQLIQEPRVLHFKDSYHNLRLSIHDVPSSLWKSKLLVSYQEIPFYHIWNGTQRYLHCTFTLERVSPSTSDLACKLWVWQVEGDGQSFSINFNITKDTRFAELLALESEAGVPALVGPSAFKIPFLIRQKIISSLDPPCRRGADWRTLAQKLHLDSHLSFFASKPSPTAMILNLWEARHFPNGNLSQLAAAVAGLGQPDAGLFTVSEAEC
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6ZN44-1; Sequence=Displayed; Name=2; IsoId=Q6ZN44-2; Sequence=VSP_011694, VSP_011695; Name=3; IsoId=Q6ZN44-3; Sequence=VSP_011693
Alternative Sequence
1..97; MAVRPGLWPALLGIVLAAWLRGSGAQQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKPVLLVCKAVPATQIFFKCNGEWVRQVDHVIERSTDGSS -> MAGTSERSLISSISQPKAIECFEVKKKAFLTHGRYHGSGATPPKTKDPKPETFCGQT (in isoform 3); 296..301; TASGPE -> SESSLP (in isoform 2); 302..842; Missing (in isoform 2)
3D Structural Models
Turn
84..86; 192..194
Helix
110..115; 256..258
Beta Strand
45..48; 61..69; 71..77; 88..93; 95..98; 100..108; 118..120; 123..129; 134..136; 158..163; 166..168; 180..185; 196..200; 206..208; 211..214; 216..224; 229..231; 235..241; 259..263; 282..287
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Domain (CC)
The ZU5 domain mediates the interaction with MAGED1, which participates in the induction of apoptosis.
Domain (FT)
44..141; Ig-like; 155..234; Ig-like C2-type; 242..294; TSP type-1; 441..584; ZU5; 761..841; Death
Region
605..623; Interaction with DCC
Protein Families
Unc-5 family
Sequence Similarities
Belongs to the unc-5 family.
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No abstract available |