Protein detail
BAKOR
Beclin 1-associated autophagy-related key regulator (Barkor) (Autophagy-related protein 14-like protein) (Atg14L)
Entry name BAKOR | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 3 | Transmembrane count | Protein classification Predicted intracellular proteinsTransporters |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Beclin 1-associated autophagy-related key regulator (Barkor) (Autophagy-related protein 14-like protein) (Atg14L)
Protein Class (2)
Predicted intracellular proteinsTransporters
Protein Function (2)
- Transporters
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
ATG14LKIAA0831
Gene Description
Autophagy related 14
Chromosome
14
Position
55366391-55411830
Supporting publications (n)
3
EVMP confidence score
0.40
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificNeutrophil progenitors
Function & Pathway
Protein Function (2)
- Transporters
- Predicted intracellular proteins
Cellular Component (12)
- GO:0000407 phagophore assembly site
- GO:0000421 autophagosome membrane
- GO:0005776 autophagosome
- GO:0005789 endoplasmic reticulum membrane
- GO:0005829 cytosol
- GO:0005930 axoneme
- GO:0034045 phagophore assembly site membrane
- GO:0035032 phosphatidylinositol 3-kinase complex, class III
- GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site
- GO:0045335 phagocytic vesicle
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Molecular Function (5)
Biological Process (3)
KEGG (8)
- hsa04140 Autophagy - animal
- KEGG:hsa05010 Alzheimer disease
- KEGG:hsa05014 Amyotrophic lateral sclerosis
- KEGG:hsa05016 Huntington disease
- KEGG:hsa05017 Spinocerebellar ataxia
- KEGG:hsa05022 Pathways of neurodegeneration - multiple diseases
- KEGG:hsa05131 Shigellosis
- KEGG:hsa05167 Kaposi sarcoma-associated herpesvirus infection
Reactome (13)
- R-hsa-1280218 adaptive immune system
- R-hsa-983170 antigen presentation folding assembly and peptide loading of class i mhc
- R-hsa-9612973 autophagy
- R-hsa-983169 class i mhc mediated antigen processing presentation
- R-hsa-9918481 dengue virus host interactions
- R-hsa-9839923 dengue virus infection
- R-hsa-9920951 dengue virus modulates apoptosis
- R-hsa-5663205 infectious disease
- R-hsa-9705671 sars cov 2 activates modulates innate and adaptive immune responses
- R-hsa-9705683 sars cov 2 host interactions
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Mediation Categories (5)
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence18
Enzyme-Mediated Modification (1)
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ATG14 | ULK1 | O75385 | S | 29 | phosphorylation | Sparser_ProtMapperProtMapperRLIMS-P_ProtMapperREACH_ProtMapperPhosphoSite | ProtMapper:27938392ProtMapper:30397185ProtMapper:29371398ProtMapper:29313410 |
Ligand-Receptor Signaling (4)
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath |
Regulatory Interaction Network (2)
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| ULK1 | O75385 | BAKOR | Q6ZNE5 | Yes | Yes | Sparser_ProtMapperARNSIGNORProtMapperRLIMS-P_ProtMapperHINTREACH_ProtMapper | ProtMapper:27938392HINT:27046250ProtMapper:30397185ProtMapper:29313410SIGNOR:27938392ProtMapper:31554253ARN:23685627ProtMapper:29371398HINT:27938392 | |
| BAKOR | Q6ZNE5 | PK3C3 | Q8NEB9 | Yes | Yes | InnateDBHINTSIGNORIntAct | HINT:23332761InnateDB:19050071HINT:35271311IntAct:19050071HINT:20562859HINT:19050071IntAct:22493499SIGNOR:19270693InnateDB:18843052HINT:33961781HINT:33422265HINT:22493499HINT:25490155HINT:24785657HINT:18843052HINT:28757208 |
Protein Complex Composition (10)
10 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| HT_DM_Cluster294 | ALDOAALDOBALDOCATG14 | P04075P05062P09972Q6ZNE5 | 1:1:1:1 | Compleat | Compleat:HC2013 | 22036573 |
| ULK1-ATG13-ATG14-PIK3C3 complex | ATG13ATG14PIK3C3ULK1 | O75143O75385Q6ZNE5Q8NEB9 | 0:0:0:0 | CORUM | CORUM:6816 | 27046250 |
| Vps34 Complex I | ATG14BECN1PIK3C3PIK3R4 | Q14457Q6ZNE5Q8NEB9Q99570 | 1:1:1:1 | SIGNORComplexPortalCompleatCFinderPDB | Compleat:HC7390SIGNOR:SIGNOR-C242intact:EBI-10687239PDB:8sor | 1475529216467569 |
| ATG14BECN1PIK3C3PIK3R4RAB1A | P62820Q14457Q6ZNE5Q8NEB9Q99570 | 1:1:1:1:1 | PDB | PDB:9mhhPDB:9mhgPDB:9mhf | ||
| ATG14BECN1MTCL3NRBF2PIK3C3PIK3R4 | Q14457Q5TF21Q6ZNE5Q8NEB9Q96F24Q99570 | 0:0:0:0:0:0 | hu.MAP2 | |||
| ATG14BECN1PIK3C3 | Q14457Q6ZNE5Q8NEB9 | 0:0:0 | KEGG-MEDICUS | |||
| ATG14BECN1NRBF2PIK3C3PIK3R4 | Q14457Q6ZNE5Q8NEB9Q96F24Q99570 | 0:0:0:0:0 | KEGG-MEDICUShu.MAP2 | |||
| AMBRA1ATG14BECN1PIK3C3PIK3R4 | Q14457Q6ZNE5Q8NEB9Q99570Q9C0C7 | 0:0:0:0:0 | KEGG-MEDICUS | |||
| ATG14MTCL3NRBF2 | Q5TF21Q6ZNE5Q96F24 | 0:0:0 | hu.MAP | |||
| ATG14GABARAPL1 | Q6ZNE5Q9H0R8 | 2:2 | PDB | PDB:6hol |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture | Mass spectrometry | 21 | 409858792682653637926756360646473811336840465195373224753330447836497184298919913406467740189497335925004094044932916986413079683330982631805958386070623820710637670049 |
Sequence, Structure & Domains
Sequences
Length
492
Mass
55,309
Sequence
MASPSGKGARALEAPGCGPRPLARDLVDSVDDAEGLYVAVERCPLCNTTRRRLTCAKCVQSGDFVYFDGRDRERFIDKKERLSRLKSKQEEFQKEVLKAMEGKWITDQLRWKIMSCKMRIEQLKQTICKGNEEMEKNSEGLLKTKEKNQKLYSRAQRHQEKKEKIQRHNRKLGDLVEKKTIDLRSHYERLANLRRSHILELTSVIFPIEEVKTGVRDPADVSSESDSAMTSSTVSKLAEARRTTYLSGRWVCDDHNGDTSISITGPWISLPNNGDYSAYYSWVEEKKTTQGPDMEQSNPAYTISAALCYATQLVNILSHILDVNLPKKLCNSEFCGENLSKQKFTRAVKKLNANILYLCFSQHVNLDQLQPLHTLRNLMYLVSPSSEHLGRSGPFEVRADLEESMEFVDPGVAGESDESGDERVSDEETDLGTDWENLPSPRFCDIPSQSVEVSQSQSTQASPPIASSSAGGMISSAAASVTSWFKAYTGHR
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6ZNE5-1; Sequence=Displayed; Name=2; IsoId=Q6ZNE5-2; Sequence=VSP_013931
Alternative Sequence
1..113; Missing (in isoform 2)
3D Structural Models
Turn
387..390
Helix
57..61; 75..204; 277..280; 299..321; 331..334; 341..361; 366..368; 374..382; 399..405
Beta Strand
208..210; 260..265; 268..271; 335..337; 435..437
3D Structure
Electron microscopy (5); X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
415..433; Acidic residues; 448..473; Low complexity
Coiled Coil
71..180
Domain (CC)
The coiled-coil domain is required for BECN1- and PIK3C3-binding and for autophagy.; DOMAIN: The final 80 residues in the C-terminus define a minimum required region for autophagosome binding called BATS.; DOMAIN: The N-terminal cysteine repeats are required for proper localization to the endoplasmic reticulum.
Region
43..58; Cysteine repeats; 410..473; Disordered; 413..492; BATS
Protein Families
ATG14 family
Sequence Similarities
Belongs to the ATG14 family.
Clinical Relevance
Supporting Publications3
| PMID | Title | Related sentences |
|---|---|---|
| 27894104 | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | No related sentences available |
| 33709510 | Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection. | No related sentences available |
| 37786918 | Rapid and in-depth proteomic profiling of small extracellular vesicles for ultralow samples. | No related sentences available |