Protein detail

GADL1

Acidic amino acid decarboxylase GADL1 (Aspartate 1-decarboxylase) (ADC) (HuADC) (EC 4.1.1.11) (Cysteine sulfinic acid decarboxylase) (CSADC) (HuCSADC) (EC 4.1.1.29) (Glutamate decarboxylase-like protein 1)

Entry name
GADL1
UniProt ID
Q6ZQY3
EVMP confidence score
0.38
Supporting publications (n)
1
Transmembrane count
Protein classification
EnzymesPredicted intracellular proteins
EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information10
Protein Names
Acidic amino acid decarboxylase GADL1 (Aspartate 1-decarboxylase) (ADC) (HuADC) (EC 4.1.1.11) (Cysteine sulfinic acid decarboxylase) (CSADC) (HuCSADC) (EC 4.1.1.29) (Glutamate decarboxylase-like protein 1)
Protein Class (2)
EnzymesPredicted intracellular proteins
Protein Function (3)
  • Enzymes
  • Predicted intracellular proteins
  • ENZYME proteins:Lyases
Ensembl
ENSG00000144644
Entrez Gene Symbol
GADL1
Gene Description
Glutamate decarboxylase like 1
Chromosome
3
Position
30726197-30894661
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization2
GADL1 fluorescence
Cell SpecificAstrocytes
Function & Pathway7
Protein Function (3)
  • Enzymes
  • Predicted intracellular proteins
  • ENZYME proteins:Lyases
Cellular Component (2)
Molecular Function (4)
Biological Process (3)
KEGG (4)
Reactome (4)
Mediation Categories
Metabolism mediation
Relations & Evidence5

Ligand-Receptor Signaling (2)

2 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularGO_IntercellNoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo

Protein Complex Composition (2)

2 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
ARL13BGADL1Q3SXY8Q6ZQY30:0hu.MAP2
ANKRD50ARL13BGADL1Q3SXY8Q6ZQY3Q9ULJ70:0:0hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationR Sequencing139363010
Sequence, Structure & Domains7

Sequences

Length
521
Mass
59,246
Sequence
MSSDSDRQCPVDGDIDQQEMIPSKKNAVLVDGVVLNGPTTDAKAGEKFVEEACRLIMEEVVLKATDVNEKVCEWRPPEQLKQLLDLEMRDSGEPPHKLLELCRDVIHYSVKTNHPRFFNQLYAGLDYYSLVARFMTEALNPSVYTYEVSPVFLLVEEAVLKKMIEFIGWKEGDGIFNPGGSVSNMYAMNLARYKYCPDIKEKGLSGSPRLILFTSAECHYSMKKAASFLGIGTENVCFVETDGRGKMIPEELEKQVWQARKEGAAPFLVCATSGTTVLGAFDPLDEIADICERHSLWLHVDASWGGSALMSRKHRKLLHGIHRADSVAWNPHKMLMAGIQCCALLVKDKSDLLKKCYSAKASYLFQQDKFYDVSYDTGDKSIQCSRRPDAFKFWMTWKALGTLGLEERVNRALALSRYLVDEIKKREGFKLLMEPEYANICFWYIPPSLREMEEGPEFWAKLNLVAPAIKERMMKKGSLMLGYQPHRGKVNFFRQVVISPQVSREDMDFLLDEIDLLGKDM
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6ZQY3-1; Sequence=Displayed; Name=2; IsoId=Q6ZQY3-3; Sequence=VSP_036227
Alternative Sequence
419..521; Missing (in isoform 2)

Domain & Motif Annotations

Protein Families
Group II decarboxylase family
Sequence Similarities
Belongs to the group II decarboxylase family.
Clinical Relevance2
Drugs
LITHIUM
Antibody (2)
HPA039160HPA040229
Supporting Publications1
PMIDTitleAbstract
32384937Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.No abstract available