Protein detail

QSOX2

Sulfhydryl oxidase 2 (EC 1.8.3.2) (Neuroblastoma-derived sulfhydryl oxidase) (Quiescin Q6-like protein 1)

Entry name QSOX2	UniProt ID Q6ZRP7	EVMP confidence score 0.25
Supporting publications (n) 2	Transmembrane count 1	Protein classification EnzymesPredicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Sulfhydryl oxidase 2 (EC 1.8.3.2) (Neuroblastoma-derived sulfhydryl oxidase) (Quiescin Q6-like protein 1)

Protein Class (3)

EnzymesPredicted intracellular proteinsPredicted membrane proteins

Protein Function (3)

Enzymes
ENZYME proteins:Oxidoreductases
Predicted intracellular proteins

Transmembrane

662..682; Helical

Transmembrane Count

Ensembl

ENSG00000165661

Entrez Gene Symbol

QSOX2

Gene Synonym (3)

DKFZp762A2013QSCN6L1SOXN

Gene Description

Quiescin sulfhydryl oxidase 2

Chromosome

Position

136206333-136245812

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization1

Function & Pathway6

Protein Function (3)

Enzymes
ENZYME proteins:Oxidoreductases
Predicted intracellular proteins

Cellular Component (6)

Molecular Function (2)

Biological Process (3)

Canonical Pathways (3)

M5880 Naba ecm affiliated
M5885 Naba matrisome associated
M5889 Naba matrisome

Mediation Categories

Other mediation

Relations & Evidence29

Ligand-Receptor Signaling (28)

28 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	MatrixDB	Yes	No	Yes	Yes	No
ecm	ecm	OmniPath	Yes	No	Yes	Yes	No
intracellular	intracellular	ComPPI	No	No	Yes	Yes	No
intracellular	intracellular	GO_Intercell	No	No	Yes	Yes	No
intracellular	intracellular	UniProt_location	No	No	Yes	Yes	No
intracellular	intracellular	OmniPath	No	No	Yes	Yes	No
cell_surface_enzyme	cell_surface_enzyme	Surfaceome	Yes	No	Yes	Yes	No
cell_surface_enzyme	cell_surface_enzyme	OmniPath	Yes	No	Yes	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	Yes	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	Yes	Yes	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Shotgun Mass Spectrometry	1	32916986

Sequence, Structure & Domains8

Sequences

Length

698

Mass

77,529

Sequence

MAAAGAAVARSPGIGAGPALRARRSPPPRAARLPRLLVLLAAAAVGPGAGGAARLYRAGEDAVWVLDSGSVRGATANSSAAWLVQFYSSWCGHCIGYAPTWRALAGDVRDWASAIRVAALDCMEEKNQAVCHDYDIHFYPTFRYFKAFTKEFTTGENFKGPDRELRTVRQTMIDFLQNHTEGSRPPACPRLDPIQPSDVLSLLDNRGSHYVAIVFESNSSYLGREVILDLIPYESIVVTRALDGDKAFLEKLGVSSVPSCYLIYPNGSHGLINVVKPLRAFFSSYLKSLPDVRKKSLPLPEKPHKEENSEIVVWREFDKSKLYTVDLESGLHYLLRVELAAHKSLAGAELKTLKDFVTVLAKLFPGRPPVKKLLEMLQEWLASLPLDRIPYNAVLDLVNNKMRISGIFLTNHIKWVGCQGSRSELRGYPCSLWKLFHTLTVEASTHPDALVGTGFEDDPQAVLQTMRRYVHTFFGCKECGEHFEEMAKESMDSVKTPDQAILWLWKKHNMVNGRLAGHLSEDPRFPKLQWPTPDLCPACHEEIKGLASWDEGHVLTFLKQHYGRDNLLDTYSADQGDSSEGGTLARGEEEEKRLTPPEVSHGDRDTQSVRPPGALGPRPALPESLHHSLDGKLQSLDGPGAHKEVGGAAPFLGVDFSSLDMSLCVVLYVASSLFLMVMYFFFRVRSRRWKVKHHHPAV

Domain & Motif Annotations

Compositional Bias

572..581; Polar residues; 586..607; Basic and acidic residues; 610..622; Low complexity

Domain (FT)

34..178; Thioredoxin; 421..530; ERV/ALR sulfhydryl oxidase

Region

570..624; Disordered

Protein Families

Quiescin-sulfhydryl oxidase (QSOX) family

Sequence Similarities

Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.

Clinical Relevance1

Antibody (2)

HPA012716 HPA017280

Supporting Publications2

PMID	Title	Abstract
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No abstract available