Protein detail
SHSA6
Protein shisa-6
Entry name SHSA6 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification Predicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Protein shisa-6
Protein Class (2)
Predicted membrane proteinsTransporters
Protein Function
Transporters:Accessory Factors Involved in Transport
Transmembrane
175..195; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
FLJ45455
Gene Description
Shisa family member 6
Chromosome
17
Position
11241213-11564063
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization1
Cell SpecificErythrocyte progenitors
Function & Pathway6
Protein Function
Transporters:Accessory Factors Involved in Transport
Cellular Component (6)
Molecular Function (3)
Biological Process (3)
Canonical Pathways (3)
- M5880 Naba ecm affiliated
- M5885 Naba matrisome associated
- M5889 Naba matrisome
Mediation Categories (2)
Fusion and delivery mediationReceptor-signaling mediation
Relations & Evidence15
Ligand-Receptor Signaling (14)
14 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| receptor | receptor | CellCellInteractions | No | Yes | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
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Sequence, Structure & Domains11
Sequences
Length
500
Mass
55,764
Sequence
MALRRLLLLLLLSLESLDLLPSVHGARGRAANRTLSAGGAAVGGRRAGGALARGGRELNGTARAPGIPEAGSRRGQPAAAVAAAASAAVTYETCWGYYDVSGQYDKEFECNNSESGYLYCCGTCYYRFCCKKRHEKLDQRQCTNYQSPVWVQTPSTKVVSPGPENKYDPEKDKTNFTVYITCGVIAFVIVAGVFAKVSYDKAHRPPREMNIHRALADILRQQGPIPIAHCERETISAIDTSPKENTPVRSSSKNHYTPVRTAKQTPEKPRMNNILTSATEPYDLSFSRSFQNLAHLPPSYESAVKTNPSKYSSLKRLTDKEADEYYMRRRHLPDLAARGTLPLNVIQMSQQKPLPRERPRRPIRAMSQDRVLSPDRGLPDEFSMPYDRILSDEQLLSTERLHSQDPLLSPERTAFPEQSLSRAISHTDVFVSTPVLDRYRMSKMHSHPSASNNSYATLGQSQTAAKRHAFASRRHNTVEQLHYIPGHHTCYTASKTEVTV
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6ZSJ9-1; Sequence=Displayed; Name=2; IsoId=Q6ZSJ9-2; Sequence=VSP_032565; Name=3; IsoId=Q6ZSJ9-3; Sequence=VSP_040558
Alternative Sequence
266; P -> PGHYGKDAYRSGGPDLHNFISSGFVTLGRGHTK (in isoform 2); 266; P -> PGHYGKDAYRSGGPDLHNFISSGFVTLGRGHTKGDHQYNHPILSSVTQIPPH (in isoform 3)
Domain & Motif Annotations
Compositional Bias
240..255; Polar residues; 448..464; Polar residues
Motif
497..500; PDZ-binding
Domain (CC)
The PDZ-binding motif interacts with PDZ-domain of scaffolding protein DLG4..
Region
52..73; Disordered; 240..269; Disordered; 349..378; Disordered; 444..470; Disordered
Protein Families
Shisa family
Sequence Similarities
Belongs to the shisa family.
Clinical Relevance1
Antibody
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 32396726 | Plasma-Derived Extracellular Vesicle Phosphoproteomics through Chemical Affinity Purification. | No abstract available |