Protein detail
ARHGI
Rho guanine nucleotide exchange factor 18 (114 kDa Rho-specific guanine nucleotide exchange factor) (p114-Rho-GEF) (p114RhoGEF) (Septin-associated RhoGEF) (SA-RhoGEF)
Protein symbol ARHGI | UniProt ID | EVMP score 0.50 |
Frequency 10 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins |
Basic Information
Protein Names
Rho guanine nucleotide exchange factor 18 (114 kDa Rho-specific guanine nucleotide exchange factor) (p114-Rho-GEF) (p114RhoGEF) (Septin-associated RhoGEF) (SA-RhoGEF)
Protein Class
Disease related genesHuman disease related genesPredicted intracellular proteins
Protein Function
- Disease related genes
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Eye disease
Ensembl
Entrez Gene Symbol
Gene Synonym
KIAA0521MGC15913P114-RhoGEFp114RhoGEF
Gene Description
Rho/Rac guanine nucleotide exchange factor 18
Chromosome
19
Position
7348937-7472485
Frequency
10
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbrainCell SpecificAdrenal medulla cellsSingle-Nuclei Brain Specificcommitted oligodendrocyte precursorBlood Cell Specificnaive B-cellBlood Lineage SpecificB-cells
Function & Pathway
Protein Function
- Disease related genes
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Eye disease
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-204998 cell death signalling via nrage nrif and nade
- R-hsa-73887 death receptor signaling
- R-hsa-416482 g alpha 12 13 signalling events
- R-hsa-193648 nrage signals death through jnk
- R-hsa-193704 p75 ntr receptor mediated signalling
- R-hsa-9013149 rac1 gtpase cycle
- R-hsa-8980692 rhoa gtpase cycle
- R-hsa-9012999 rho gtpase cycle
- R-hsa-372790 signaling by gpcr
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
- R-hsa-9006936 signaling by tgfb family members
- R-hsa-170834 signaling by tgf beta receptor complex
- R-hsa-2173791 tgf beta receptor signaling in emt epithelial to mesenchymal transition
Canonical Pathways
- M5880 Naba ecm affiliated
- M5885 Naba matrisome associated
- M5889 Naba matrisome
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| apical_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| SEPT9 | Q9UHD8 | ARHGI | Q6ZSZ5 | Yes | No | Yes | SIGNOR | SIGNOR:15558029 |
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Shotgun Mass Spectrometry | 1 | 32916986 |
Sequence, Structure & Domains
Sequences
Length
1,361
Mass
151,642
Sequence
MGDDQEDDFPRRLSESMEDLSLDLGALQGSEYLQDLGLGAPSHSQPGETPDSRPTGEEPGRDSLFSSLAGSQDLSRRRSWERSRSCSESWRRLSLDASAVDEEPCLPRTLASLALNLPGGGLKTWTQGCLSGGGTPAESPGKECDSPKKRGRSRSVPVSFYEIRSPEISPGLEVPTPPVQGLEPPVLECMEKDHVEPDHVLIVQQVLQELRQYHGARQRACMSASPGGAHSNLTWFEFLSESEDGAGKNEKSDKSTSVKRRLSCLRSRVTRQKEKGKSPAHLKDKGQDARERRECVNGHQLLQGTFSGPSSCPLCGKPFLSSASLKEHPRGTLLSDGSPALSRNVGMTVSQKGGPQPTPSPAGPGTQLGPITGEMDEADSAFLKFKQTADDSLSLTSPNTESIFVEDPYTASLRSEIESDGHEFEAESWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSKLKNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVDSKPPVISLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQRAVESCPDEEEGPFSLPEEERKVVEARATRLRDFQERLSMKDQLIAQSLLEKQQIYLEMAEMGGLEDLPQPRGLFRGGDPSETLQGELILKSAMSEIEGIQSLICRQLGSANGQAEDGGSSTGPPRRAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPPNSPDLKLSDSDIPGSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVIAHQDSYVETQRAAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHEQQRWERERQWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREAQRAVERERERLELLRRLKKQNTAPGALPPDTLAEAQPPSHPPSFNGEGLEGPRVSMLPSGVGPEYAERPEVARRDSAPTENRLAKSDVPIQLLSATNQFQRQAAVQQQIPTKLAASTKGGKDKGGKSRGSQRWESSASFDLKQQLLLNKLMGKDESTSRNRRSLSPILPGRHSPAPPPDPGFPAPSPPPADSPSEGFSLKAGGTALLPGPPAPSPLPATPLSAKEDASKEDVIFF
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=LOCGEF-X3; IsoId=Q6ZSZ5-4; Sequence=Displayed; Name=2; Synonyms=LOCGEF-X4; IsoId=Q6ZSZ5-5; Sequence=VSP_059877; Name=3; Synonyms=LOCGEF-X5; IsoId=Q6ZSZ5-6; Sequence=VSP_059876; Name=4; Synonyms=p114; IsoId=Q6ZSZ5-2; Sequence=VSP_059874; Name=5; IsoId=Q6ZSZ5-1; Sequence=VSP_059875
Alternative Sequence
1..346; Missing (in isoform 4); 1..322; MGDDQEDDFPRRLSESMEDLSLDLGALQGSEYLQDLGLGAPSHSQPGETPDSRPTGEEPGRDSLFSSLAGSQDLSRRRSWERSRSCSESWRRLSLDASAVDEEPCLPRTLASLALNLPGGGLKTWTQGCLSGGGTPAESPGKECDSPKKRGRSRSVPVSFYEIRSPEISPGLEVPTPPVQGLEPPVLECMEKDHVEPDHVLIVQQVLQELRQYHGARQRACMSASPGGAHSNLTWFEFLSESEDGAGKNEKSDKSTSVKRRLSCLRSRVTRQKEKGKSPAHLKDKGQDARERRECVNGHQLLQGTFSGPSSCPLCGKPFLSS -> MVTVGTNILPSRPAASANTAREDAALFSRRIPPRHKNGAAQPGAAPGPGAPGANMGNAHSKSGDRHSALPGRPELSFYGSFPRKWSENVFLDNELLTSKILSMLRPQSERGFRAGDLRYPTHFLSTNSVLASVT (in isoform 5); 1..16; Missing (in isoform 3); 1..5; MGDDQ -> MTTVA (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
50..61; Basic and acidic residues; 64..73; Polar residues; 74..88; Basic and acidic residues; 245..256; Basic and acidic residues; 271..292; Basic and acidic residues; 1191..1211; Basic and acidic residues; 1254..1264; Polar residues; 1300..1317; Pro residues; 1334..1344; Pro residues; 1349..1361; Basic and acidic residues
Coiled Coil
1038..1148
Zinc Finger
310..334; C2H2-type; degenerate
Domain (FT)
447..644; DH; 684..786; PH
Region
33..88; Disordered; 131..156; Disordered; 244..292; Disordered; 348..368; Disordered; 893..980; Disordered; 1143..1211; Disordered; 1229..1264; Disordered; 1277..1361; Disordered