Protein detail
BCAP
Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1)
Protein symbol BCAP | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
BCAPFLJ35564
Gene Description
Phosphoinositide-3-kinase adaptor protein 1
Chromosome
10
Position
96593315-96720514
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Reactome
- R-hsa-1280218 adaptive immune system
- R-hsa-983695 antigen activates b cell receptor bcr leading to generation of second messengers
- R-hsa-2219530 constitutive signaling by aberrant pi3k in cancer
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-9006925 intracellular signaling by second messengers
- R-hsa-199418 negative regulation of the pi3k akt network
- R-hsa-2219528 pi3k akt signaling in cancer
- R-hsa-983705 signaling by the b cell receptor bcr
Mediation Categories
Clinical-translation mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
7 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PIK3AP1 | ABL1 | P00519 | Y | 513 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperdbPTMPhosphoSitePhosphoSite_ProtMapper | dbPTM:15893754 |
| PIK3AP1 | ABL1 | P00519 | Y | 553 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperdbPTMPhosphoSitePhosphoSite_ProtMapper | dbPTM:15893754 |
| PIK3AP1 | ABL1 | P00519 | Y | 570 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperdbPTMPhosphoSitePhosphoSite_ProtMapper | dbPTM:15893754 |
| PIK3AP1 | ABL1 | P00519 | Y | 594 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperdbPTMPhosphoSitePhosphoSite_ProtMapper | dbPTM:15893754 |
| PIK3AP1 | ABL1 | P00519 | Y | 694 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPProtMapperdbPTMPhosphoSitePhosphoSite_ProtMapper | dbPTM:18083107dbPTM:17693683dbPTM:15893754 |
| PIK3AP1 | SRC | P12931 | Y | 459 | phosphorylation | Li2012 | |
| PIK3AP1 | SYK | P43405 | Y | 459 | phosphorylation | Li2012 |
Ligand-Receptor Signaling
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
6 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| ABL1 | P00519 | BCAP | Q6ZUJ8 | Yes | No | No | SPIKEphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefiPTMnetProtMapperdbPTMSPIKE_LCPhosphoSitePhosphoSite_ProtMapper | SPIKE_LC:15893754dbPTM:15893754SPIKE_LC:20841568dbPTM:18083107SPIKE:15893754PhosphoSite:15893754dbPTM:17693683SPIKE:20841568 |
| BCAP | Q6ZUJ8 | PK3CB | P42338 | Yes | Yes | No | WangSIGNOR | SIGNOR:22187458 |
| BCAP | Q6ZUJ8 | COMPLEX:P27986_P42336 | Yes | Yes | No | SIGNOR | SIGNOR:22187458 | |
| BCAP | Q6ZUJ8 | PK3CG | P48736 | Yes | Yes | No | WangSIGNOR | SIGNOR:22187458 |
| BCAP | Q6ZUJ8 | P85A | P27986 | Yes | Yes | No | WangHPRDNetPathSIGNOR | SIGNOR:22187458NetPath:11163197HPRD:11163197 |
| BCAP | Q6ZUJ8 | PK3CA | P42336 | Yes | Yes | No | WangSIGNOR | SIGNOR:22187458 |
Protein Complex Composition
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| DOK1NCK2PIK3AP1WIPF3 | A6NGB9O43639Q6ZUJ8Q99704 | 0:0:0:0 | hu.MAP | |||
| N4BP2L2PIK3AP1WLSWNT4WNT7AWNT7B | O00755P56705P56706Q5T9L3Q6ZUJ8Q92802 | 0:0:0:0:0:0 | hu.MAP2 | |||
| ATF7IPERCC3GTF2E1GTF2E2PIK3AP1SPTBN1 | P19447P29083P29084Q01082Q6VMQ6Q6ZUJ8 | 1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC3908 | ||
| PIK3AP1 | Q6ZUJ8 | 5 | PDB | PDB:6sws |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometryMass spectrometry [MALDI TOF]Western blottingFACS|Western blottingImmunoelectron Microscopy|Western blotting|FACSFACSFACS|Immunoelectron MicroscopyImmunoelectron Microscopy|Western blotting | 2 | 3936301032002171 |
Sequence, Structure & Domains
Sequences
Length
805
Mass
90,398
Sequence
MAASGVPRGCDILIVYSPDAEEWCQYLQTLFLSSRQVRSQKILTHRLGPEASFSAEDLSLFLSTRCVVVLLSAELVQHFHKPALLPLLQRAFHPPHRVVRLLCGVRDSEEFLDFFPDWAHWQELTCDDEPETYVAAVKKAISEDSGCDSVTDTEPEDEKVVSYSKQQNLPTVTSPGNLMVVQPDRIRCGAETTVYVIVRCKLDDRVATEAEFSPEDSPSVRMEAKVENEYTISVKAPNLSSGNVSLKIYSGDLVVCETVISYYTDMEEIGNLLSNAANPVEFMCQAFKIVPYNTETLDKLLTESLKNNIPASGLHLFGINQLEEEDMMTNQRDEELPTLLHFAAKYGLKNLTALLLTCPGALQAYSVANKHGHYPNTIAEKHGFRDLRQFIDEYVETVDMLKSHIKEELMHGEEADAVYESMAHLSTDLLMKCSLNPGCDEDLYESMAAFVPAATEDLYVEMLQASTSNPIPGDGFSRATKDSMIRKFLEGNSMGMTNLERDQCHLGQEEDVYHTVDDDEAFSVDLASRPPVPVPRPETTAPGAHQLPDNEPYIFKVFAEKSQERPGNFYVSSESIRKGPPVRPWRDRPQSSIYDPFAGMKTPGQRQLITLQEQVKLGIVNVDEAVLHFKEWQLNQKKRSESFRFQQENLKRLRDSITRRQREKQKSGKQTDLEITVPIRHSQHLPAKVEFGVYESGPRKSVIPPRTELRRGDWKTDSTSSTASSTSNRSSTRSLLSVSSGMEGDNEDNEVPEVTRSRSPGPPQVDGTPTMSLERPPRVPPRAASQRPPTRETFHPPPPVPPRGR
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=BCAP-L; IsoId=Q6ZUJ8-1; Sequence=Displayed; Name=2; Synonyms=BCAP-S; IsoId=Q6ZUJ8-2; Sequence=VSP_034238; Name=3; IsoId=Q6ZUJ8-3; Sequence=VSP_034239, VSP_034240
Alternative Sequence
1..178; Missing (in isoform 2); 1..57; MAASGVPRGCDILIVYSPDAEEWCQYLQTLFLSSRQVRSQKILTHRLGPEASFSAED -> MRFFTSVACYGSCLFASELLIRCKDWLKGRPALFTALLACVLYLCEWTGAKHVPGSS (in isoform 3); 58..458; Missing (in isoform 3)
3D Structural Models
Turn
35..39
Helix
18..20; 21..33; 55..63; 73..79; 85..91; 95..97; 109..113; 118..120; 130..138; 265..273; 279..286
Beta Strand
12..16; 42..46; 65..71; 98..104; 121..124; 179..182; 184..190; 192..200; 209..213; 215..217; 220..228; 231..236; 241..252; 254..263; 276..278
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
654..672; Basic and acidic residues; 707..716; Basic and acidic residues; 717..740; Low complexity; 795..805; Pro residues
Coiled Coil
645..667
Domain (CC)
The DBB domain is required for dimerization.
Domain (FT)
8..145; TIR; 181..317; DBB
Region
10..144; Necessary and sufficient to mediate inhibition of NF-kappa-B downstream of activated TLRs; may mediate interaction with MYD88 and TIRAP; 145..165; Disordered; 527..547; Disordered; 571..590; Disordered; 654..679; Disordered; 697..805; Disordered