Protein detail

FRMD7

FERM domain-containing protein 7

Entry name
FRMD7
UniProt ID
Q6ZUT3
EVMP confidence score
0.53
Supporting publications (n)
2
Transmembrane count
Protein classification
Cancer-related genesDisease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsTransporters
Basic Information
Protein Names
FERM domain-containing protein 7
Protein Class (6)
Cancer-related genesDisease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsTransporters
Protein Function (6)
  • Predicted intracellular proteins
  • Cancer-related genes:Mutated cancer genes
  • Potential drug targets
  • Transporters:Accessory Factors Involved in Transport
  • Disease related genes
  • Human disease related genes:Nervous system diseases:Eye disease
Ensembl
ENSG00000165694
Entrez Gene Symbol
FRMD7
Gene Synonym (3)
FLJ43346NYSNYS1
Gene Description
FERM domain containing 7
Chromosome
X
Position
132076990-132128020
Supporting publications (n)
2
EVMP confidence score
0.53
Fluorescence & Localization
FRMD7 fluorescence
Tissue Specificlymphoid tissueCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificeosinophilBlood Lineage SpecificgranulocytesSecretome LocationIntracellular and membraneSecretome FunctionImmunity
Function & Pathway
Protein Function (6)
  • Predicted intracellular proteins
  • Cancer-related genes:Mutated cancer genes
  • Potential drug targets
  • Transporters:Accessory Factors Involved in Transport
  • Disease related genes
  • Human disease related genes:Nervous system diseases:Eye disease
Cellular Component (8)
Molecular Function (3)
Biological Process (3)
Mediation Categories (2)
Fusion and delivery mediationReceptor-signaling mediation
Relations & Evidence8

Ligand-Receptor Signaling (7)

7 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
ecmecmMatrixDBYes
ecmecmOmniPathYes
intracellularintracellularComPPI
intracellularintracellularGO_Intercell
intracellularintracellularOmniPath
ferm_domainintracellular_intercellular_relatedHGNCYes
intracellular_intercellular_relatedintracellular_intercellular_relatedOmniPathYes

Isolation & Detection Technology (1)

Sequence, Structure & Domains

Sequences

Length
714
Mass
81,614
Sequence
MLHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQSELGDFHEETDRKHLAQTRYLPNQDCLEGKIMHFHQKHIGRSPAESDILLLDIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFRYSGRTQRQLLEYGRKGRLKSLPFERKHYPSQYHERQCRSSPDLLSDVSKQVEDLRLAYGGGYYQNVNGVHASEPVLESRRRNSALEVTFATELEHSKPEADPTLLHQSQSSSSFPFIYMDPVFNTEPNPNPDPRDIFSERSSLSSFQTSCKFSGNHMSIYSGLTSKVRPAKQLTYTDVPYIPCTGQQVGIMPPQVFFYVDKPPQVPRWSPIRAEERTSPHSYVEPTAMKPAERSPRNIRMKSFQQDLQVLQEAIARTSGRSNINVGLEEEDPNLEDAFVCNIQEQTPKRSQSQSDMKTIRFPFGSEFRPLGPCPALSHKADLFTDMFAEQELPAVLMDQSTAERYVASESSDSESEILKPDYYALYGKEIRSPMARIRLSSGSLQLDEEDEDAYFNTPTAEDRTSLKPCNYFLA
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6ZUT3-1; Sequence=Displayed; Name=2; Synonyms=S; IsoId=Q6ZUT3-2; Sequence=VSP_038722
Alternative Sequence
69..84; NPKEIVFKFMVKFFPV -> M (in isoform 2)

Domain & Motif Annotations

Coiled Coil
537..558
Domain (FT)
2..282; FERM
Clinical Relevance
Disease Involvement (2)
Cancer-related genesDisease variant
Antibody
HPA000886
Supporting Publications2
PMIDTitleRelated sentences
28986585Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics.No related sentences available
32089743Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism.No related sentences available