Protein detail

FRMD7

FERM domain-containing protein 7

Entry name FRMD7	UniProt ID Q6ZUT3	EVMP score 0.38
Frequency 2	Transmembrane count	Protein classification Cancer-related genesDisease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsTransporters

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

FERM domain-containing protein 7

Protein Class

Cancer-related genesDisease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsTransporters

Protein Function

Predicted intracellular proteins
Cancer-related genes:Mutated cancer genes
Potential drug targets
Transporters:Accessory Factors Involved in Transport
Disease related genes
Human disease related genes:Nervous system diseases:Eye disease

Ensembl

ENSG00000165694

Entrez Gene Symbol

FRMD7

Gene Synonym

FLJ43346NYSNYS1

Gene Description

FERM domain containing 7

Chromosome

Position

132076990-132128020

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue Specificlymphoid tissueCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificeosinophilBlood Lineage SpecificgranulocytesSecretome LocationIntracellular and membraneSecretome FunctionImmunity

Function & Pathway

Protein Function

Predicted intracellular proteins
Cancer-related genes:Mutated cancer genes
Potential drug targets
Transporters:Accessory Factors Involved in Transport
Disease related genes
Human disease related genes:Nervous system diseases:Eye disease

Cellular Component

Molecular Function

Biological Process

Mediation Categories

Fusion and delivery mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	MatrixDB	Yes	No	No	No	No
ecm	ecm	OmniPath	Yes	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
ferm_domain	intracellular_intercellular_related	HGNC	Yes	No	No	No	No
intracellular_intercellular_related	intracellular_intercellular_related	OmniPath	Yes	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryR Sequencing	50	40985879 27086912 36064647 38113368 28680152 40465195 36736734 34815502 35119778 37322475 33304478 36497184 25755179 34064677 26826536 38895962 31382537 41068253 33592500 32854315 38014595 34473505 38891077 38917926 30915084 32560723 32916986 41307968 36146834 35763629 33309826 40691760 27821849 40840701 37670049 31805958 33893753 38607062 32230970 38207106 38716512 34576246 37204515 39001700 36982312 37438638 39207047 37670049 37926756 40831280

Sequence, Structure & Domains

Sequences

Length

714

Mass

81,614

Sequence

MLHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQSELGDFHEETDRKHLAQTRYLPNQDCLEGKIMHFHQKHIGRSPAESDILLLDIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFRYSGRTQRQLLEYGRKGRLKSLPFERKHYPSQYHERQCRSSPDLLSDVSKQVEDLRLAYGGGYYQNVNGVHASEPVLESRRRNSALEVTFATELEHSKPEADPTLLHQSQSSSSFPFIYMDPVFNTEPNPNPDPRDIFSERSSLSSFQTSCKFSGNHMSIYSGLTSKVRPAKQLTYTDVPYIPCTGQQVGIMPPQVFFYVDKPPQVPRWSPIRAEERTSPHSYVEPTAMKPAERSPRNIRMKSFQQDLQVLQEAIARTSGRSNINVGLEEEDPNLEDAFVCNIQEQTPKRSQSQSDMKTIRFPFGSEFRPLGPCPALSHKADLFTDMFAEQELPAVLMDQSTAERYVASESSDSESEILKPDYYALYGKEIRSPMARIRLSSGSLQLDEEDEDAYFNTPTAEDRTSLKPCNYFLA

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6ZUT3-1; Sequence=Displayed; Name=2; Synonyms=S; IsoId=Q6ZUT3-2; Sequence=VSP_038722

Alternative Sequence

69..84; NPKEIVFKFMVKFFPV -> M (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Coiled Coil

537..558

Domain (FT)

2..282; FERM

Clinical Relevance

Disease Involvement

Cancer-related genesDisease variant

Antibody

HPA000886