Protein detail
TGRM2
TOG array regulator of axonemal microtubules protein 2 (Crescerin-2)
Entry name TGRM2 | UniProt ID | EVMP score 0.38 |
Frequency 2 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
TOG array regulator of axonemal microtubules protein 2 (Crescerin-2)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
Crescerin-2FAM179AFLJ43249LOC165186
Gene Description
TOG array regulator of axonemal microtubules 2
Chromosome
2
Position
28956611-29052230
Frequency
2
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificovaryCell SpecificBrain excitatory neuronsSingle-Nuclei Brain SpecificLAMP5-LHX6 and Chandelier
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Other mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
2 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometryMass spectrometry [LTQ-FT Ultra] | 1 | 36750568 |
Sequence, Structure & Domains
Sequences
Length
1,019
Mass
111,153
Sequence
MGTRDDVPEAKVLVPVAVYCGSIPRTSAGPRVLPPGSINSSLPHGEGSLQPEPRALLNNEEPSQLLRGLGQLGGLKLDTPSKGWQARNGHPRNLRALSLGDQPLVLLPSPESEANSVARDTIQIKDKLKKRRLSEGLAASSRASLDPGGGPQGVPLHSTIPRATSQRLLRVPRPMPLIQSIPTTPEASGVKEKGLDLPGSIPGPHELRPGAQEAQISWQYLHCNDEKMQKSLGAIVIPPIPKARTVAATPSRVPGSLPSPLPPGQGVLTGLRAPRTRLARGSGPREKTPASLEPKPLASPIRDRPAAAKKPALPFSQSAPTLTAFSFDCAREACPPLKEEDQKEIGTKIQVTISKSAREKMQLKQMKEMELLRRLEEPRTGQELTSQCLGSQRAFMKEGLLPLRGSGTLSVPTRLSGPCRNDVSIILRKWASRASLPSIPISRQEPRFARHASANSLPAVLTLGSPEWEEEEEMDLRACKELRPFSNPELGLRDALQCLNSSDWQMKEKGLVSIQRLAACHSEVLTGKLHDVCLVVTGEVTNLRSKVSHLAISTLGDLFQALKKNMDQEAEEIARCLLQKMADTNEFIQRAAGQSLRAMVENVTLARSLVVLTSAGVYHRNPLIRKYAAEHLSAVLEQIGAEKLLSGTRDSTDMLVHNLVRLAQDSNQDTRFYGRKMVNILMANTKFDAFLKQSLPSYDLQKVMAAIKQQGIEDNDELPSAKGRKVLRSLVVCENGLPIKEGLSCNGPRLVGLRSTLQGRGEMVEQLRELTRLLEAKDFRSRMEGVGQLLELCKAKTELVTAHLVQVFDAFTPRLQDSNKKVNQWALESFAKMIPLLRESLHPMLLSIIITVADNLNSKNSGIYAAAVAVLDAMVESLDNLCLLPALAGRVRFLSGRAVLDVTDRLAVLVASVYPRKPQAVERHVLPILWHFLNTATRNGTLPGPSGNIRGVVCRLSRSLQEHMGSRLLDFAASQPKHVLKTLQELLDSESLGGSRKATDRGVAPDSKTTGSSYPFQLD
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6ZUX3-1; Sequence=Displayed; Name=2; IsoId=Q6ZUX3-2; Sequence=VSP_032492; Name=3; IsoId=Q6ZUX3-3; Sequence=VSP_032491, VSP_032493, VSP_032494, VSP_032495
Alternative Sequence
1..702; Missing (in isoform 3); 1..473; Missing (in isoform 2); 703..710; VMAAIKQQ -> MLCVYFFK (in isoform 3); 908..949; VLVASVYPRKPQAVERHVLPILWHFLNTATRNGTLPGPSGNI -> GEHPQPHPTPSPGRFLFSPGLWLNHSPSYLRPEIIPPNHLKF (in isoform 3); 950..1019; Missing (in isoform 3)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
1007..1019; Polar residues
Region
28..54; Disordered; 131..158; Disordered; 249..311; Disordered; 991..1019; Disordered
Protein Families
Crescerin family
Sequence Similarities
Belongs to the Crescerin family.