Protein detail

PTHD4

Patched domain-containing protein 4 (p53-regulated patched protein)

Entry name
PTHD4
UniProt ID
EVMP confidence score
0.50
Supporting publications (n)
1
Transmembrane count
12
Protein classification
Predicted membrane proteins
EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information12
Protein Names
Patched domain-containing protein 4 (p53-regulated patched protein)
Protein Class
Predicted membrane proteins
Transmembrane
41..61; Helical; 230..250; Helical; 265..285; Helical; 293..313; Helical; 336..356; Helical; 373..393; Helical; 465..485; Helical; 660..680; Helical; 686..706; Helical; 718..738; Helical; 765..785; Helical; 787..807; Helical
Transmembrane Count
12
Entrez Gene Symbol
Gene Synonym (4)
C6orf138dJ402H5.2FLJ41841PTCH53
Gene Description
Patched domain containing 4
Chromosome
6
Position
47856673-48111197
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization4
Tissue Specificadipose tissueCell SpecificExtravillous trophoblastsSecretome LocationSecreted to bloodSecretome FunctionNo annotated function
Function & Pathway5
Relations & Evidence11

Ligand-Receptor Signaling (10)

10 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
receptorreceptorOmniPathNoYesNoNoNo
transmembranetransmembraneUniProt_locationNoNoNoNoNo
transmembranetransmembraneUniProt_topologyNoNoNoNoNo
transmembranetransmembraneUniProt_keywordNoNoNoNoNo
transmembranetransmembraneRamilowski_locationNoNoNoNoNo
transmembranetransmembraneOmniPathNoNoNoNoNo
cell_surfacecell_surfaceSurfaceomeNoNoNoNoNo
cell_surfacecell_surfaceOmniPathNoNoNoNoNo
receptorreceptorCellCellInteractionsNoYesNoNoNo
transmembranetransmembrane_predictedPhobiusNoNoNoNoNo

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyWestern blottingELISA3387318682677501337922300
Sequence, Structure & Domains8

Sequences

Length
846
Mass
96,371
Sequence
MCFLRRPGAPASWIWWRMLRQVLRRGLQSFCHRLGLCVSRHPVFFLTVPAVLTITFGLSALNRFQPEGDLERLVAPSHSLAKIERSLASSLFPLDQSKSQLYSDLHTPGRYGRVILLSPTGDNILLQAEGILQTHRAVLEMKDGRNSFIGHQLGGVVEVPNSKDQRVKSARAIQITYYLQTYGSATQDLIGEKWENEFCKLIRKLQEEHQELQLYSLASFSLWRDFHKTSILARSKVLVSLVLILTTATLSSSMKDCLRSKPFLGLLGVLTVCISIITAAGIFFITDGKYNSTLLGIPFFAMGHGTKGVFELLSGWRRTKENLPFKDRIADAYSDVMVTYTMTSSLYFITFGMGASPFTNIEAVKVFCQNMCVSILLNYFYIFSFFGSCLVFAGQLEQNRYHSIFCCKIPSAEYLDRKPVWFQTVMSDGHQQTSHHETNPYQHHFIQHFLREHYNEWITNIYVKPFVVILYLIYASFSFMGCLQISDGANIINLLASDSPSVSYAMVQQKYFSNYSPVIGFYVYEPLEYWNSSVQDDLRRLCSGFTAVSWVEQYYQFLKVSNVSANNKSDFISVLQSSFLKKPEFQHFRNDIIFSKAGDESNIIASRLYLVARTSRDKQKEITEVLEKLRPLSLSKSIRFIVFNPSFVFMDHYSLSVTVPVLIAGFGVLLVLILTFFLVIHPLGNFWLILSVTSIELGVLGLMTLWNVDMDCISILCLIYTLNFAIDHCAPLLFTFVLATEHTRTQCIKSSLQDHGTAILQNVTSFLIGLVPLLFVPSNLTFTLFKCLLLTGGCTLLHCFVILPVFLTFFPPSKKHHKKKKRAKRKEREEIECIEIQENPDHVTTV
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q6ZW05-1; Sequence=Displayed; Name=2; IsoId=Q6ZW05-2; Sequence=VSP_056623, VSP_056624, VSP_056625; Name=3; IsoId=Q6ZW05-3; Sequence=VSP_058428; Name=4; IsoId=Q6ZW05-4; Sequence=VSP_058427
Alternative Sequence
1..253; Missing (in isoform 4); 1..17; Missing (in isoform 2); 1..4; MCFL -> M (in isoform 3); 304..311; HGTKGVFE -> ISTEFTSS (in isoform 2); 312..846; Missing (in isoform 2)

Domain & Motif Annotations

Domain (FT)
233..392; SSD
Protein Families
Patched family
Sequence Similarities
Belongs to the patched family.
Clinical Relevance1
Antibody
Supporting Publications1
PMIDTitleAbstract
39363010Proteomic analysis of plasma-derived extracellular vesicles: pre- and postprandial comparisons.No abstract available