Protein detail
PTHD4
Patched domain-containing protein 4 (p53-regulated patched protein)
Entry name PTHD4 | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 1 | Transmembrane count 12 | Protein classification Predicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Patched domain-containing protein 4 (p53-regulated patched protein)
Protein Class
Predicted membrane proteins
Transmembrane
41..61; Helical; 230..250; Helical; 265..285; Helical; 293..313; Helical; 336..356; Helical; 373..393; Helical; 465..485; Helical; 660..680; Helical; 686..706; Helical; 718..738; Helical; 765..785; Helical; 787..807; Helical
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
C6orf138dJ402H5.2FLJ41841PTCH53
Gene Description
Patched domain containing 4
Chromosome
6
Position
47856673-48111197
Supporting publications (n)
1
EVMP confidence score
0.40
Fluorescence & Localization
Tissue Specificadipose tissueCell SpecificExtravillous trophoblastsSecretome LocationSecreted to bloodSecretome FunctionNo annotated function
Function & Pathway
Cellular Component (2)
Molecular Function
Biological Process (3)
Canonical Pathways
M121 Pid mtor 4pathway
Mediation Categories
Other mediation
Relations & Evidence11
Ligand-Receptor Signaling (10)
10 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | Yes | ||||
| transmembrane | transmembrane | UniProt_location | |||||
| transmembrane | transmembrane | UniProt_topology | |||||
| transmembrane | transmembrane | UniProt_keyword | |||||
| transmembrane | transmembrane | Ramilowski_location | |||||
| transmembrane | transmembrane | OmniPath | |||||
| cell_surface | cell_surface | Surfaceome | |||||
| cell_surface | cell_surface | OmniPath | |||||
| receptor | receptor | CellCellInteractions | Yes | ||||
| transmembrane | transmembrane_predicted | Phobius |
Sequence, Structure & Domains
Sequences
Length
846
Mass
96,371
Sequence
MCFLRRPGAPASWIWWRMLRQVLRRGLQSFCHRLGLCVSRHPVFFLTVPAVLTITFGLSALNRFQPEGDLERLVAPSHSLAKIERSLASSLFPLDQSKSQLYSDLHTPGRYGRVILLSPTGDNILLQAEGILQTHRAVLEMKDGRNSFIGHQLGGVVEVPNSKDQRVKSARAIQITYYLQTYGSATQDLIGEKWENEFCKLIRKLQEEHQELQLYSLASFSLWRDFHKTSILARSKVLVSLVLILTTATLSSSMKDCLRSKPFLGLLGVLTVCISIITAAGIFFITDGKYNSTLLGIPFFAMGHGTKGVFELLSGWRRTKENLPFKDRIADAYSDVMVTYTMTSSLYFITFGMGASPFTNIEAVKVFCQNMCVSILLNYFYIFSFFGSCLVFAGQLEQNRYHSIFCCKIPSAEYLDRKPVWFQTVMSDGHQQTSHHETNPYQHHFIQHFLREHYNEWITNIYVKPFVVILYLIYASFSFMGCLQISDGANIINLLASDSPSVSYAMVQQKYFSNYSPVIGFYVYEPLEYWNSSVQDDLRRLCSGFTAVSWVEQYYQFLKVSNVSANNKSDFISVLQSSFLKKPEFQHFRNDIIFSKAGDESNIIASRLYLVARTSRDKQKEITEVLEKLRPLSLSKSIRFIVFNPSFVFMDHYSLSVTVPVLIAGFGVLLVLILTFFLVIHPLGNFWLILSVTSIELGVLGLMTLWNVDMDCISILCLIYTLNFAIDHCAPLLFTFVLATEHTRTQCIKSSLQDHGTAILQNVTSFLIGLVPLLFVPSNLTFTLFKCLLLTGGCTLLHCFVILPVFLTFFPPSKKHHKKKKRAKRKEREEIECIEIQENPDHVTTV
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q6ZW05-1; Sequence=Displayed; Name=2; IsoId=Q6ZW05-2; Sequence=VSP_056623, VSP_056624, VSP_056625; Name=3; IsoId=Q6ZW05-3; Sequence=VSP_058428; Name=4; IsoId=Q6ZW05-4; Sequence=VSP_058427
Alternative Sequence
1..253; Missing (in isoform 4); 1..17; Missing (in isoform 2); 1..4; MCFL -> M (in isoform 3); 304..311; HGTKGVFE -> ISTEFTSS (in isoform 2); 312..846; Missing (in isoform 2)
Domain & Motif Annotations
Domain (FT)
233..392; SSD
Protein Families
Patched family
Sequence Similarities
Belongs to the patched family.
Clinical Relevance
Antibody
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 39363010 | Proteomic analysis of plasma-derived extracellular vesicles: pre- and postprandial comparisons. | No related sentences available |