Protein detail

STXB4

Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (STX4-interacting protein) (Synip)

Entry name STXB4	UniProt ID Q6ZWJ1	EVMP confidence score 0.50
Supporting publications (n) 6	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (STX4-interacting protein) (Synip)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000166263

Entrez Gene Symbol

STXBP4

Gene Synonym (2)

MGC50337Synip

Gene Description

Syntaxin binding protein 4

Chromosome

Position

54968727-55173632

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Tissue SpecificbrainCell SpecificCardiomyocytesSingle-Nuclei Brain Specificcentral nervous system macrophage

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (3)

Molecular Function (2)

Biological Process (3)

Canonical Pathways (3)

M5887 Naba basement membranes
M53 Pid integrin3 pathway
M3005 Naba collagens

Mediation Categories (2)

Fusion and delivery mediationMetabolism mediation

Relations & Evidence12

Enzyme-Mediated Modification (3)

3 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
STXBP4	AKT2	P31751	S	99	phosphorylation	RLIMS-P_ProtMapperSIGNORProtMapper	SIGNOR:15753124 ProtMapper:15753124
STXBP4	INS	P01308	S	99	phosphorylation	REACH_ProtMapperSparser_ProtMapperProtMapper	ProtMapper:29686650
STXBP4	AKT3	Q9Y243	S	99	phosphorylation	RLIMS-P_ProtMapperProtMapper	ProtMapper:15753124

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network (3)

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
STXB4	Q6ZWJ1	YAP1	P46937	Yes	No	Yes	SIGNOR	SIGNOR:31782549
AKT2	P31751	STXB4	Q6ZWJ1	Yes	No	Yes	Sparser_ProtMapperiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperACSNSIGNOR_ProtMapperREACH_ProtMapper	ACSN:15753124 SIGNOR:15753124 ProtMapper:27530212 ProtMapper:32940941 ProtMapper:15753124 ProtMapper:17276404
STXB4	Q6ZWJ1	STX4	Q12846	Yes	Yes	Yes	HPRDWangSIGNOR	SIGNOR:15753124 HPRD:10394363 HPRD:12855681

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	MAGI1 PTPN14 STXBP4	Q15678 Q6ZWJ1 Q96QZ7	0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	R Sequencing	2	30608700 38321535

Sequence, Structure & Domains9

Sequences

Length

553

Mass

61,662

Sequence

MNKNTSTVVSPSLLEKDPAFQMITIAKETGLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKSIITGAKLRLESAWEIAFIRQKSDNIQPENLSCTSLIEASGEYGPQASTLSLFSSPPEILIPKTSSTPKTNNDILSSCEIKTGYNKTVQIPITSENSTVGLSNTDVASAWTENYGLQEKISLNPSVRFKAEKLEMALNYLGIQPTKEQHQALRQQVQADSKGTVSFGDFVQVARNLFCLQLDEVNVGAHEISNILDSQLLPCDSSEADEMERLKCERDDALKEVNTLKEKLLESDKQRKQLTEELQNVKQEAKAVVEETRALRSRIHLAEAAQRQAHGMEMDYEEVIRLLEAKITELKAQLADYSDQNKESVQDLKKRIMVLDCQLRKSEMARKTFEASTEKLLHFVEAIQEVFSDNSTPLSNLSERRAVLASQTSLTPLGRNGRSIPATLALESKELVKSVRALLDMDCLPYGWEEAYTADGIKYFINHVTQTTSWIHPVMSVLNLSRSEENEEDCSRELPNQKS

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6ZWJ1-1; Sequence=Displayed; Name=2; IsoId=Q6ZWJ1-2; Sequence=VSP_017175, VSP_017176, VSP_017177, VSP_017178

Alternative Sequence

1..77; Missing (in isoform 2); 95; L -> LST (in isoform 2); 316..320; EKLLE -> WPGQN (in isoform 2); 321..553; Missing (in isoform 2)

3D Structural Models

Beta Strand

502..506; 508..510; 512..519

3D Structure

NMR spectroscopy (1)

Domain & Motif Annotations

Coiled Coil

291..417

Domain (FT)

19..105; PDZ; 496..529; WW

Clinical Relevance1

Antibody (4)

CAB007760 HPA022138 HPA022888 HPA024227

Supporting Publications6

PMID	Title	Abstract
30646616	Preferential Localization of MUC1 Glycoprotein in Exosomes Secreted by Non-Small Cell Lung Carcinoma Cells.	THBS1, ANXA6, HIST1H4A, COL18A1, MDK, SRGN, ENO1, TUBA4A, SLC3A2, GPI, MIF, MUC1, TALDO1, SLC7A5, ICAM1, HSP90AA1, G6PD, and LRP1 were found to be expressed in exosomes at more than 5-fold higher level as compared to total cellular membrane proteins.
32284825	Unravelling the proteomic landscape of extracellular vesicles in prostate cancer by density-based fractionation of urine.	No abstract available
32795414	Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.	Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers.
33709510	Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.	No abstract available
35611462	Extracellular vesicles expressing CEACAM proteins in the urine of bladder cancer patients.	No abstract available
38321535	Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles.	No abstract available