Protein detail
STXB4
Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (STX4-interacting protein) (Synip)
Protein symbol STXB4 | UniProt ID | EVMP score 0.50 |
Frequency 6 | Transmembrane count | Protein classification Predicted intracellular proteins |
Basic Information
Protein Names
Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (STX4-interacting protein) (Synip)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
MGC50337Synip
Gene Description
Syntaxin binding protein 4
Chromosome
17
Position
54968727-55173632
Frequency
6
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbrainCell SpecificCardiomyocytesSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Canonical Pathways
- M5887 Naba basement membranes
- M53 Pid integrin3 pathway
- M3005 Naba collagens
Mediation Categories
Fusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
3 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| STXBP4 | AKT2 | P31751 | S | 99 | phosphorylation | RLIMS-P_ProtMapperSIGNORProtMapper | SIGNOR:15753124ProtMapper:15753124 |
| STXBP4 | INS | P01308 | S | 99 | phosphorylation | REACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:29686650 |
| STXBP4 | AKT3 | Q9Y243 | S | 99 | phosphorylation | RLIMS-P_ProtMapperProtMapper | ProtMapper:15753124 |
Ligand-Receptor Signaling
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| STXB4 | Q6ZWJ1 | YAP1 | P46937 | Yes | No | Yes | SIGNOR | SIGNOR:31782549 |
| AKT2 | P31751 | STXB4 | Q6ZWJ1 | Yes | No | Yes | Sparser_ProtMapperiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperACSNSIGNOR_ProtMapperREACH_ProtMapper | ACSN:15753124SIGNOR:15753124ProtMapper:27530212ProtMapper:32940941ProtMapper:15753124ProtMapper:17276404 |
| STXB4 | Q6ZWJ1 | STX4 | Q12846 | Yes | Yes | Yes | HPRDWangSIGNOR | SIGNOR:15753124HPRD:10394363HPRD:12855681 |
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
553
Mass
61,662
Sequence
MNKNTSTVVSPSLLEKDPAFQMITIAKETGLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKSIITGAKLRLESAWEIAFIRQKSDNIQPENLSCTSLIEASGEYGPQASTLSLFSSPPEILIPKTSSTPKTNNDILSSCEIKTGYNKTVQIPITSENSTVGLSNTDVASAWTENYGLQEKISLNPSVRFKAEKLEMALNYLGIQPTKEQHQALRQQVQADSKGTVSFGDFVQVARNLFCLQLDEVNVGAHEISNILDSQLLPCDSSEADEMERLKCERDDALKEVNTLKEKLLESDKQRKQLTEELQNVKQEAKAVVEETRALRSRIHLAEAAQRQAHGMEMDYEEVIRLLEAKITELKAQLADYSDQNKESVQDLKKRIMVLDCQLRKSEMARKTFEASTEKLLHFVEAIQEVFSDNSTPLSNLSERRAVLASQTSLTPLGRNGRSIPATLALESKELVKSVRALLDMDCLPYGWEEAYTADGIKYFINHVTQTTSWIHPVMSVLNLSRSEENEEDCSRELPNQKS
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6ZWJ1-1; Sequence=Displayed; Name=2; IsoId=Q6ZWJ1-2; Sequence=VSP_017175, VSP_017176, VSP_017177, VSP_017178
Alternative Sequence
1..77; Missing (in isoform 2); 95; L -> LST (in isoform 2); 316..320; EKLLE -> WPGQN (in isoform 2); 321..553; Missing (in isoform 2)
3D Structural Models
Beta Strand
502..506; 508..510; 512..519
3D Structure
NMR spectroscopy (1)
Domain & Motif Annotations
Coiled Coil
291..417
Domain (FT)
19..105; PDZ; 496..529; WW