Protein detail
UBP53
Ubiquitin carboxyl-terminal hydrolase 53 (EC 3.4.19.12) (Ubiquitin-specific peptidase 53)
Entry name UBP53 | UniProt ID | EVMP confidence score 0.28 |
Supporting publications (n) 2 | Transmembrane count | Protein classification Disease related genesEnzymesHuman disease related genesPotential drug targetsPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Ubiquitin carboxyl-terminal hydrolase 53 (EC 3.4.19.12) (Ubiquitin-specific peptidase 53)
Protein Class (5)
Disease related genesEnzymesHuman disease related genesPotential drug targetsPredicted intracellular proteins
Protein Function (6)
- Predicted intracellular proteins
- Human disease related genes:Digestive system diseases:Liver diseases
- Potential drug targets
- Peptidases:Cysteine-type peptidases
- Enzymes
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym
KIAA1350
Gene Description
Ubiquitin specific peptidase 53
Chromosome
4
Position
119212587-119295518
Supporting publications (n)
2
EVMP confidence score
0.28
Fluorescence & Localization
Tissue SpecifictestisCell SpecificEarly primary spermatocytes
Function & Pathway
Protein Function (6)
- Predicted intracellular proteins
- Human disease related genes:Digestive system diseases:Liver diseases
- Potential drug targets
- Peptidases:Cysteine-type peptidases
- Enzymes
- Disease related genes
Cellular Component (3)
Molecular Function
Biological Process (3)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence5
Ligand-Receptor Signaling (4)
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | OmniPath | |||||
| tight_junction | tight_junction | GO_Intercell | Yes | Yes | |||
| tight_junction | tight_junction | OmniPath | Yes | Yes |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Shotgun Mass Spectrometry | 1 | 32916986 |
Sequence, Structure & Domains
Sequences
Length
1,073
Mass
120,806
Sequence
MAWVKFLRKPGGNLGKVYQPGSMLSLAPTKGLLNEPGQNSCFLNSAVQVLWQLDIFRRSLRVLTGHVCQGDACIFCALKTIFAQFQHSREKALPSDNIRHALAESFKDEQRFQLGLMDDAAECFENMLERIHFHIVPSRDADMCTSKSCITHQKFAMTLYEQCVCRSCGASSDPLPFTEFVRYISTTALCNEVERMLERHERFKPEMFAELLQAANTTDDYRKCPSNCGQKIKIRRVLMNCPEIVTIGLVWDSEHSDLTEAVVRNLATHLYLPGLFYRVTDENAKNSELNLVGMICYTSQHYCAFAFHTKSSKWVFFDDANVKEIGTRWKDVVSKCIRCHFQPLLLFYANPDGTAVSTEDALRQVISWSHYKSVAENMGCEKPVIHKSDNLKENGFGDQAKQRENQKFPTDNISSSNRSHSHTGVGKGPAKLSHIDQREKIKDISRECALKAIEQKNLLSSQRKDLEKGQRKDLGRHRDLVDEDLSHFQSGSPPAPNGFKQHGNPHLYHSQGKGSYKHDRVVPQSRASAQIISSSKSQILAPGEKITGKVKSDNGTGYDTDSSQDSRDRGNSCDSSSKSRNRGWKPMRETLNVDSIFSESEKRQHSPRHKPNISNKPKSSKDPSFSNWPKENPKQKGLMTIYEDEMKQEIGSRSSLESNGKGAEKNKGLVEGKVHGDNWQMQRTESGYESSDHISNGSTNLDSPVIDGNGTVMDISGVKETVCFSDQITTSNLNKERGDCTSLQSQHHLEGFRKELRNLEAGYKSHEFHPESHLQIKNHLIKRSHVHEDNGKLFPSSSLQIPKDHNAREHIHQSDEQKLEKPNECKFSEWLNIENSERTGLPFHVDNSASGKRVNSNEPSSLWSSHLRTVGLKPETAPLIQQQNIMDQCYFENSLSTECIIRSASRSDGCQMPKLFCQNLPPPLPPKKYAITSVPQSEKSESTPDVKLTEVFKATSHLPKHSLSTASEPSLEVSTHMNDERHKETFQVRECFGNTPNCPSSSSTNDFQANSGAIDAFCQPELDSISTCPNETVSLTTYFSVDSCMTDTYRLKYHQRPKLSFPESSGFCNNSLS
Domain & Motif Annotations
Compositional Bias
407..418; Polar residues; 524..541; Low complexity; 553..563; Polar residues; 612..627; Low complexity
Domain (FT)
30..351; USP
Region
391..437; Disordered; 485..636; Disordered
Protein Families
Peptidase C19 family
Sequence Similarities
Belongs to the peptidase C19 family.
Clinical Relevance
Disease Involvement (3)
DeafnessDisease variantIntrahepatic cholestasis
Related Diseases (2)
Interaction Protein
ENSG00000167193
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications2
| PMID | Title | Related sentences |
|---|---|---|
| 29148239 | Metabolic Signature of Microvesicles from Umbilical Cord Mesenchymal Stem Cells of Preterm and Term Infants. | No related sentences available |
| 33709510 | Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection. | No related sentences available |