Protein detail
ANO5
Anoctamin-5 (Gnathodiaphyseal dysplasia 1 protein) (Transmembrane protein 16E)
Protein symbol ANO5 | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 8 | Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Anoctamin-5 (Gnathodiaphyseal dysplasia 1 protein) (Transmembrane protein 16E)
Protein Class
Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters
Protein Function
- Potential drug targets
- Human disease related genes:Musculoskeletal diseases:Skeletal diseases
- Human disease related genes:Musculoskeletal diseases:Muscular diseases
- Transporters:Transporter channels and pores
- Disease related genes
Transmembrane
300..320; Helical; 381..401; Helical; 463..483; Helical; 512..532; Helical; 558..578; Helical; 680..700; Helical; 733..753; Helical; 835..855; Helical
Transmembrane Count
8
Ensembl
Entrez Gene Symbol
Gene Synonym
GDD1LGMD2LTMEM16E
Gene Description
Anoctamin 5
Chromosome
11
Position
21782659-22283567
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Tissue SpecifictestisCell SpecificCardiomyocytes
Function & Pathway
Protein Function
- Potential drug targets
- Human disease related genes:Musculoskeletal diseases:Skeletal diseases
- Human disease related genes:Musculoskeletal diseases:Muscular diseases
- Transporters:Transporter channels and pores
- Disease related genes
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-9733458 induction of cell cell fusion
- R-hsa-5663205 infectious disease
- R-hsa-983712 ion channel transport
- R-hsa-9772573 late sars cov 2 infection events
- R-hsa-9694516 sars cov 2 infection
- R-hsa-9679506 sars cov infections
- R-hsa-2672351 stimuli sensing channels
- R-hsa-382551 transport of small molecules
- R-hsa-9824446 viral infection pathways
Canonical Pathways
- M185 Pid alk1 pathway
- M181 Pid bmp pathway
- M286 Pid tgfbr pathway
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
17 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | UniProt_location | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture | Mass spectrometry | 21 | 231615133119696839290459409280273150850039873726327954143038291738731868363328892316151328242843306087003370951037926697376863663849095840098346307605384009145531320591 |
Sequence, Structure & Domains
Sequences
Length
913
Mass
107,188
Sequence
MGDPDLLEVLAEEGEKVNKHIDYSFQMSEQSLSSRETSFLINEETMPAKRFNLFLRRRLMFQKNQQSKDSIFFRDGIRQIDFVLSYVDDVKKDAELKAERRKEFETNLRKTGLELEIEDKRDSEDGRTYFVKIHAPWEVLVTYAEVLGIKMPIKESDIPRPKHTPISYVLGPVRLPLSVKYPHPEYFTAQFSRHRQELFLIEDQATFFPSSSRNRIVYYILSRCPFGIEDGKKRFGIERLLNSNTYSSAYPLHDGQYWKPSEPPNPTNERYTLHQNWARFSYFYKEQPLDLIKNYYGEKIGIYFVFLGFYTEMLFFAAVVGLACFIYGLLSMEHNTSSTEICDPEIGGQMIMCPLCDQVCDYWRLNSTCLASKFSHLFDNESTVFFAIFMGIWVTLFLEFWKQRQARLEYEWDLVDFEEEQQQLQLRPEFEAMCKHRKLNAVTKEMEPYMPLYTRIPWYFLSGATVTLWMSLVVTSMVAVIVYRLSVFATFASFMESDASLKQVKSFLTPQITTSLTGSCLNFIVILILNFFYEKISAWITKMEIPRTYQEYESSLTLKMFLFQFVNFYSSCFYVAFFKGKFVGYPGKYTYLFNEWRSEECDPGGCLIELTTQLTIIMTGKQIFGNIKEAIYPLALNWWRRRKARTNSEKLYSRWEQDHDLESFGPLGLFYEYLETVTQFGFVTLFVASFPLAPLLALINNIVEIRVDAWKLTTQYRRTVASKAHSIGVWQDILYGMAVLSVATNAFIVAFTSDIIPRLVYYYAYSTNATQPMTGYVNNSLSVFLIADFPNHTAPSEKRDFITCRYRDYRYPPDDENKYFHNMQFWHVLAAKMTFIIVMEHVVFLVKFLLAWMIPDVPKDVVERIKREKLMTIKILHDFELNKLKENLGINSNEFAKHVMIEENKAQLAKSTL
3D Structural Models
Domain & Motif Annotations
Protein Families
Anoctamin family
Sequence Similarities
Belongs to the anoctamin family.
Clinical Relevance
Disease Involvement
Disease variantLimb-girdle muscular dystrophyOsteogenesis imperfecta
Antibody