Protein detail

KNDC1

Kinase non-catalytic C-lobe domain-containing protein 1 (KIND domain-containing protein 1) (Cerebral protein 9) (Protein very KIND) (v-KIND) (Ras-GEF domain-containing family member 2)

Entry name
KNDC1
UniProt ID
Q76NI1
EVMP confidence score
0.53
Supporting publications (n)
4
Transmembrane count
Protein classification
Predicted intracellular proteins
Basic Information
Protein Names
Kinase non-catalytic C-lobe domain-containing protein 1 (KIND domain-containing protein 1) (Cerebral protein 9) (Protein very KIND) (v-KIND) (Ras-GEF domain-containing family member 2)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
ENSG00000171798
Entrez Gene Symbol
KNDC1
Gene Synonym (7)
bB439H18.3C10orf23FLJ25027KIAA1768RASGEF2v-KINDVery-KIND
Gene Description
Kinase non-catalytic C-lobe domain containing 1
Chromosome
10
Position
133160219-133226412
Supporting publications (n)
4
EVMP confidence score
0.53
Fluorescence & Localization
KNDC1 fluorescence
Cell SpecificMyonuclei
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (5)
Molecular Function (2)
Biological Process (3)
Mediation Categories
Receptor-signaling mediation
Relations & Evidence6

Ligand-Receptor Signaling (4)

4 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularComPPI
intracellularintracellularGO_Intercell
intracellularintracellularUniProt_location
intracellularintracellularOmniPath

Regulatory Interaction Network (1)

1 record.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
KNDC1Q76NI1MTAP2P11137YesYesSIGNORSIGNOR:17984326

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Mass spectrometry0
Sequence, Structure & Domains

Sequences

Length
1,749
Mass
191,397
Sequence
MQAMDPAAADLYEEDGKDLDFYDFEPLPTLPEDEENVSLADILSLRDRGLSEQEAWAVCLECSLSMRSVAHAAIFQSLCITPDTLAFNTSGNVCFMEQLSDDPEGAFVPPEFDVTGNTFEAHIYSLGATLKAALEYVAEPTLEPRLSQDLEALLSRMQAEDPGDRPDLESIIALCEEKLQLTSSCRVCRSLSAVGRRVLSIESFGALQDVSESSWRERPAPGNAGPRRPPGDPSTDPEVLPTPEGPESETSRGPRASPTKALLSTPVRNGESHSREGLAGLVLDAERTLGELDRDALRRSRLRKVQTFPRLLSDSPEATLCLPLTRGKSQLPISELFSPDPRKAFLDRKNGLSSFQAQPKCRLWPEQEPEHQLGRVPCAGRSTDRGPGVPGSPGQPETSHPSQGPAEAPADPRDASGEAQTPRDDERIPEGARQLESAAAEQWVSLQDLLSQLGRPFREYELWALCLACLRALQTRPEHPAYLCLDSVLVAEDGAVLFQPPPANGSYDSFFLAPELAEERLVTEKASVYCVAAVLWTAAKFSVPRNHKLALPRRLKTLLLDMARRSAPERPSAAEAIKVCGSYLLQRGMDSRKILAHLRASICQVYQEEETISLQNAFSVVELKPSVAPAPEPSPGFLPVNSDTGLVAVPGPVPGQHPCGEEATQLPAAFTSEATHFKPIVLAQNASVARDQPALAQEESEERGGQREGEGEEKLSLEAHAGSPSLKTPDGPVPGPGPQGAAPEPLGASVQRDSAQGRPCPPPQAPANQPEGASSAAPGSPVPAPPTKASALPVEQGPAEPIPPGVASGGLRPDALGPTTAHHGPRHPPKPPRSKATERPGQEPEGPGATPAGERDDQSPDSVPERPRPADRRLCLPCVDASPLPGRTACPSLQEATRLIQEEFAFDGYLDNGLEALIMGEYIFALKDLTFATFCGAISEKFCDLYWDEKLLQNLFKVVNGQASPSPSTAEEAGSQLEGSQSPRSPSSKRPSLHRLGKEKPAMARTSSRAPCSPTSVSDVDSDALSRGNFEVGFRPQRSVKAERAQQPEAGEDRRPAGGASDVEAVTRLARSKGVGPALSPGPAGFQSCSPGWCSAFYEADCFGADVHNYVKDLGRQQADGALPDAQSPELEQQLMMEKRNYRKTLKFYQKLLQKEKRNKGSDVKTMLSKLKGQLEEMKSRVQFLSLVKKYLQVMYAERWGLEPCTLPVIVNIAAAPCDTLDFSPLDESSSLIFYNVNKHPGGRQKARILQAGTPLGLMAYLYSSDAFLEGYVQQFLYTFRYFCTPHDFLHFLLDRINSTLTRAHQDPTSTFTKIYRRSLCVLQAWVEDCYAVDFPRNSGLLGKLEDFISSKILPLDGSAKHLLGLLEVGMDRRAEGNPRGTDLENPREAEEDARPFNALCKRLSEDGISRKSFPWRLPRGNGLVLPPHKERPYTIAAALPKPCFLEDFYGPCAKTSEKGPYFLTEYSTHQLFSQLTLLQQELFQKCHPVHFLNSRALGVMDKSTAIPKASSSESLSAKTCSLFLPNYVQDKYLLQLLRNADDVSTWVAAEIVTSHTSKLQVNLLSKFLLIAKSCYEQRNFATAMQILSGLEHLAVRQSPAWRILPAKIAEVMEELKAVEVFLKSDSLCLMEGRRFRAQPTLPSAHLLAMHIQQLETGGFTMTNGAHRWSKLRNIAKVVSQVHAFQENPYTFSPDPKLQSYLKQRIARFSGADISTLAADSRANFHQVSSEKHSRKIQDKLRRMKATFQ
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q76NI1-1; Sequence=Displayed; Name=2; IsoId=Q76NI1-4; Sequence=VSP_028595, VSP_028598
Alternative Sequence
1130..1396; ELEQQLMMEKRNYRKTLKFYQKLLQKEKRNKGSDVKTMLSKLKGQLEEMKSRVQFLSLVKKYLQVMYAERWGLEPCTLPVIVNIAAAPCDTLDFSPLDESSSLIFYNVNKHPGGRQKARILQAGTPLGLMAYLYSSDAFLEGYVQQFLYTFRYFCTPHDFLHFLLDRINSTLTRAHQDPTSTFTKIYRRSLCVLQAWVEDCYAVDFPRNSGLLGKLEDFISSKILPLDGSAKHLLGLLEVGMDRRAEGNPRGTDLENPREAEEDARP -> VSPRPWHCRVGQGVSFQQSFLVTAGDRWHRVPRAPNRVTLVLVPPPRGCQDGQGPLPGLSSTSRDRLVCTGAPGGSTSEDREGLFSHGRPGDGFTGGPSMLVTRLRSVVFSVGQAQPPGPWAASLCSERKHQKRLPSKSRLGLVAAAWSGLSGQQCHPGSGAAATPPWPAGRGGLRPGSPGCRRGLQSSGRKVGPVTHSPDLGCILESPGTPGWMTGGAQWPSAPGTSPTTVCLELSHRGKPPPASGHRSPSWGSSLLLSCRLLACTL (in isoform 2); 1397..1749; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias
363..373; Basic and acidic residues; 410..430; Basic and acidic residues; 702..717; Basic and acidic residues; 739..748; Low complexity; 766..779; Low complexity; 823..833; Basic residues; 853..871; Basic and acidic residues; 980..990; Low complexity; 1005..1019; Polar residues; 1040..1056; Basic and acidic residues
Coiled Coil
1133..1190
Domain (FT)
37..217; KIND 1; 444..608; KIND 2; 1246..1371; N-terminal Ras-GEF; 1468..1719; Ras-GEF
Region
210..275; Disordered; 361..435; Disordered; 689..871; Disordered; 962..1061; Disordered
Clinical Relevance
Antibody (2)
HPA039624HPA056143
Supporting Publications4
PMIDTitleRelated sentences
30550287Label-Free Proteomic Analysis of Exosomes Secreted from THP-1-Derived Macrophages Treated with IFN-α Identifies Antiviral Proteins Enriched in Exosomes.No related sentences available
37686366Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics.No related sentences available
37922300Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women.No related sentences available
38136601Identification of Central Nervous System Oncologic Disease Biomarkers in EVs from Cerebrospinal Fluid (CSF) of Pediatric Patients: A Pilot Neuro-Proteomic Study.No related sentences available