Protein detail

BT2A1

Butyrophilin subfamily 2 member A1

Protein symbol BT2A1	UniProt ID Q7KYR7	EVMP score 0.50
Frequency 1	Transmembrane count 1	Protein classification Predicted intracellular proteinsPredicted membrane proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Butyrophilin subfamily 2 member A1

Protein Class

Predicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins

Transmembrane

249..269; Helical

Transmembrane Count

Ensembl

ENSG00000112763

Entrez Gene Symbol

BTN2A1

Gene Synonym

BT2.1BTF1BTN2.1

Gene Description

Butyrophilin subfamily 2 member A1

Chromosome

Position

26457904-26476621

Frequency

EVMP Score

0.50

Fluorescence & Localization

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

Reactome

Mediation Categories

Fusion and delivery mediationImmune mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

30 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	TopDB	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	Cellinker	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	No	No	No	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

6 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
BTN2A1 BTN2A2 EVA1C SFT2D3 TMX4 UPK3BL1	B0FP48 P58658 Q587I9 Q7KYR7 Q8WVV5 Q9H1E5	0:0:0:0:0:0	hu.MAP2
BTN2A1 BTN3A1	O00481 Q7KYR7	2:2	PDB	PDB:8za9PDB:8jyePDB:8zabPDB:8zaaPDB:8dfxPDB:8jyc
BTN2A1 BTN2A2 SFT2D3	Q587I9 Q7KYR7 Q8WVV5	0:0:0	hu.MAP2
BTN2A1 BTN2A2 SFT2D3 TMX4	Q587I9 Q7KYR7 Q8WVV5 Q9H1E5	0:0:0:0	hu.MAP2
BTN2A1	Q7KYR7	2	PDB	PDB:8dfwPDB:8vc7PDB:9jq6PDB:8dfy
BTN2A1 BTN2A2	Q7KYR7 Q8WVV5	0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	12	38113368 35119778 33304478 35399949 32854315 38891077 32560723 41307968 31805958 38207106 38716512 39001700

Sequence, Structure & Domains

Sequences

Length

527

Mass

59,633

Sequence

MESAAALHFSRPASLLLLLLSLCALVSAQFIVVGPTDPILATVGENTTLRCHLSPEKNAEDMEVRWFRSQFSPAVFVYKGGRERTEEQMEEYRGRTTFVSKDISRGSVALVIHNITAQENGTYRCYFQEGRSYDEAILHLVVAGLGSKPLISMRGHEDGGIRLECISRGWYPKPLTVWRDPYGGVAPALKEVSMPDADGLFMVTTAVIIRDKSVRNMSCSINNTLLGQKKESVIFIPESFMPSVSPCAVALPIIVVILMIPIAVCIYWINKLQKEKKILSGEKEFERETREIALKELEKERVQKEEELQVKEKLQEELRWRRTFLHAVDVVLDPDTAHPDLFLSEDRRSVRRCPFRHLGESVPDNPERFDSQPCVLGRESFASGKHYWEVEVENVIEWTVGVCRDSVERKGEVLLIPQNGFWTLEMHKGQYRAVSSPDRILPLKESLCRVGVFLDYEAGDVSFYNMRDRSHIYTCPRSAFSVPVRPFFRLGCEDSPIFICPALTGANGVTVPEEGLTLHRVGTHQSL

Alternative Products

Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q7KYR7-2; Sequence=Displayed; Name=2; IsoId=Q7KYR7-1; Sequence=VSP_035843, VSP_035844; Name=3; IsoId=Q7KYR7-3; Sequence=VSP_012708; Name=4; IsoId=Q7KYR7-4; Sequence=VSP_043165, VSP_043166; Name=5; IsoId=Q7KYR7-5; Sequence=VSP_044249; Name=6; IsoId=Q7KYR7-6; Sequence=VSP_045005, VSP_045006

Alternative Sequence

1..152; Missing (in isoform 3); 1..61; Missing (in isoform 5); 247..262; CAVALPIIVVILMIPI -> L (in isoform 2); 328..334; VDVVLDP -> ELQFFSN (in isoform 4); 328..330; VDV -> GPV (in isoform 6); 331..527; Missing (in isoform 6); 335..527; Missing (in isoform 4); 482..527; VPVRPFFRLGCEDSPIFICPALTGANGVTVPEEGLTLHRVGTHQSL -> GPDTSQSGDPPEPIESIPWSHSHVDKPWSFQQPPHNTHLPAASFTPTTDLSPSFLLLTRLCF (in isoform 2)

3D Structural Models

Turn

103..106; 224..227; 354..359; 456..459; 466..469; 505..508

Helix

85..87; 90..92; 117..119; 238..240; 334..336; 417..419

Beta Strand

39..42; 47..55; 62..69; 71..79; 95..102; 107..112; 121..131; 133..144; 150..157; 160..172; 175..179; 189..195; 201..209; 216..223; 228..235; 324..327; 341..343; 347..352; 374..378; 381..391; 397..404; 409..411; 421..427; 430..433; 448..455; 460..465; 470..474; 484..490; 492..494; 497..499; 516..518

3D Structure

Electron microscopy (6); X-ray crystallography (6)

Domain & Motif Annotations

Domain (FT)

29..141; Ig-like V-type; 310..506; B30.2/SPRY

Protein Families

Immunoglobulin superfamily
BTN/MOG family

Sequence Similarities

Belongs to the immunoglobulin superfamily. BTN/MOG family.

Clinical Relevance

Antibody

HPA019208