Protein detail

DOK3

Docking protein 3 (Downstream of tyrosine kinase 3)

Protein symbol DOK3	UniProt ID Q7L591	EVMP score 0.50
Frequency 2	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Docking protein 3 (Downstream of tyrosine kinase 3)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000146094

Entrez Gene Symbol

DOK3

Gene Synonym

FLJ22570

Gene Description

Docking protein 3

Chromosome

Position

177501904-177511274

Frequency

EVMP Score

0.50

Fluorescence & Localization

Cell SpecificAlveolar cells type 2Blood Lineage SpecificB-cells

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

GO:0005515 protein binding

Biological Process

Reactome

Mediation Categories

Fusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

6 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Regulatory Interaction Network

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
LYN	P07948	DOK3	Q7L591	Yes	Yes	No	HPRDPhosphoPointSIGNOR	SIGNOR:32323266 HPRD:10733577
DOK3	Q7L591	GRB2	P62993	Yes	Yes	No	SPIKE_LCSIGNOR	SPIKE_LC:17290227 SIGNOR:32323266

Protein Complex Composition

4 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database
ACSL5 DOK3 PGK2 RALB TPP2	P07205 P11234 P29144 Q7L591 Q9ULC5	0:0:0:0:0	hu.MAP2
DOK3 HSPG2 TPP2	P29144 P98160 Q7L591	0:0:0	hu.MAP
DOK3 TPP2	P29144 Q7L591	0:0	hu.MAP
CARS1 DOK3 QTRT2	P49589 Q7L591 Q9H974	0:0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry [LTQ-FT Ultra]Mass spectrometry	5	32938681 31753726 24670152 30865381 36028467

Sequence, Structure & Domains

Sequences

Length

496

Mass

53,288

Sequence

MTRGARLRSDARAQLNQLSLDGGTGSGQKGKCEEFPSSLSSVSPGLEAAALLLAVTMDPLETPIKDGILYQQHVKFGKKCWRKVWALLYAGGPSGVARLESWEVRDGGLGAAGDRSAGPGRRGERRVIRLADCVSVLPADGESCPRDTGAFLLTTTERSHLLAAQHRQAWMGPICQLAFPGTGEASSGSTDAQSPKRGLVPMEENSIYSSWQEVGEFPVVVQRTEAATRCQLKGPALLVLGPDAIQLREAKGTQALYSWPYHFLRKFGSDKGVFSFEAGRRCHSGEGLFAFSTPCAPDLCRAVAGAIARQRERLPELTRPQPCPLPRATSLPSLDTPGELREMPPGPEPPTSRKMHLAEPGPQSLPLLLGPEPNDLASGLYASVCKRASGPPGNEHLYENLCVLEASPTLHGGEPEPHEGPGSRSPTTSPIYHNGQDLSWPGPANDSTLEAQYRRLLELDQVEGTGRPDPQAGFKAKLVTLLSRERRKGPAPCDRP

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q7L591-1; Sequence=Displayed; Name=2; IsoId=Q7L591-2; Sequence=VSP_013713, VSP_013715, VSP_013716; Name=3; IsoId=Q7L591-3; Sequence=VSP_013712, VSP_013715, VSP_013716; Name=4; IsoId=Q7L591-4; Sequence=VSP_013712, VSP_013714, VSP_013715, VSP_013716

Alternative Sequence

1..170; Missing (in isoform 2); 1..56; Missing (in isoform 3 and isoform 4); 79..180; Missing (in isoform 4); 272..386; GVFSFEAGRRCHSGEGLFAFSTPCAPDLCRAVAGAIARQRERLPELTRPQPCPLPRATSLPSLDTPGELREMPPGPEPPTSRKMHLAEPGPQSLPLLLGPEPNDLASGLYASVCK -> ILLGTPGVSLLICKGERTDDVSGIILDESLLRAYSVPGAGGHSRVQDSLGPVLREPTFQGERSFLKTSMLRSLLCSCSWRHPRSQPRTQASCLQGSDCPAPHRNSTSAAHTLGTS (in isoform 2, isoform 3 and isoform 4); 387..496; Missing (in isoform 2, isoform 3 and isoform 4)

3D Structural Models

Domain & Motif Annotations

Domain (CC)

PTB domain mediates receptor interaction.

Domain (FT)

63..179; PH; 213..317; IRS-type PTB

Region

18..38; Disordered; 313..363; Disordered; 408..447; Disordered

Protein Families

DOK family
Type A subfamily

Sequence Similarities

Belongs to the DOK family. Type A subfamily.

Clinical Relevance

Antibody

HPA077312

Interaction Protein

ENSG00000146648

Interaction Count

Interaction Dataset

intact_biogrid