Protein detail

DOK3

Docking protein 3 (Downstream of tyrosine kinase 3)

Entry name DOK3	UniProt ID Q7L591	EVMP confidence score 0.53
Supporting publications (n) 2	Transmembrane count	Protein classification Predicted intracellular proteins

Basic Information

Protein Names

Docking protein 3 (Downstream of tyrosine kinase 3)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000146094

Entrez Gene Symbol

DOK3

Gene Synonym

FLJ22570

Gene Description

Docking protein 3

Chromosome

Position

177501904-177511274

Supporting publications (n)

EVMP confidence score

0.53

Fluorescence & Localization

Cell SpecificAlveolar cells type 2Blood Lineage SpecificB-cells

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component (4)

Molecular Function

GO:0005515 protein binding

Biological Process (3)

Reactome (2)

Mediation Categories (3)

Fusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence13

Ligand-Receptor Signaling (6)

6 records.

Category	Parent	Database
intracellular	intracellular	ComPPI
intracellular	intracellular	GO_Intercell
intracellular	intracellular	UniProt_location
intracellular	intracellular	OmniPath
plasma_membrane	plasma_membrane	UniProt_location
plasma_membrane	plasma_membrane	OmniPath

Regulatory Interaction Network (2)

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
LYN	P07948	DOK3	Q7L591	Yes	Yes		HPRDPhosphoPointSIGNOR	SIGNOR:32323266 HPRD:10733577
DOK3	Q7L591	GRB2	P62993	Yes	Yes		SPIKE_LCSIGNOR	SPIKE_LC:17290227 SIGNOR:32323266

Protein Complex Composition (4)

4 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database
ACSL5 DOK3 PGK2 RALB TPP2	P07205 P11234 P29144 Q7L591 Q9ULC5	0:0:0:0:0	hu.MAP2
DOK3 HSPG2 TPP2	P29144 P98160 Q7L591	0:0:0	hu.MAP
DOK3 TPP2	P29144 Q7L591	0:0	hu.MAP
CARS1 DOK3 QTRT2	P49589 Q7L591 Q9H974	0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry [LTQ-FT Ultra]Mass spectrometry	5	32938681 31753726 24670152 30865381 36028467

Sequence, Structure & Domains

Sequences

Length

496

Mass

53,288

Sequence

MTRGARLRSDARAQLNQLSLDGGTGSGQKGKCEEFPSSLSSVSPGLEAAALLLAVTMDPLETPIKDGILYQQHVKFGKKCWRKVWALLYAGGPSGVARLESWEVRDGGLGAAGDRSAGPGRRGERRVIRLADCVSVLPADGESCPRDTGAFLLTTTERSHLLAAQHRQAWMGPICQLAFPGTGEASSGSTDAQSPKRGLVPMEENSIYSSWQEVGEFPVVVQRTEAATRCQLKGPALLVLGPDAIQLREAKGTQALYSWPYHFLRKFGSDKGVFSFEAGRRCHSGEGLFAFSTPCAPDLCRAVAGAIARQRERLPELTRPQPCPLPRATSLPSLDTPGELREMPPGPEPPTSRKMHLAEPGPQSLPLLLGPEPNDLASGLYASVCKRASGPPGNEHLYENLCVLEASPTLHGGEPEPHEGPGSRSPTTSPIYHNGQDLSWPGPANDSTLEAQYRRLLELDQVEGTGRPDPQAGFKAKLVTLLSRERRKGPAPCDRP

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q7L591-1; Sequence=Displayed; Name=2; IsoId=Q7L591-2; Sequence=VSP_013713, VSP_013715, VSP_013716; Name=3; IsoId=Q7L591-3; Sequence=VSP_013712, VSP_013715, VSP_013716; Name=4; IsoId=Q7L591-4; Sequence=VSP_013712, VSP_013714, VSP_013715, VSP_013716

Alternative Sequence

1..170; Missing (in isoform 2); 1..56; Missing (in isoform 3 and isoform 4); 79..180; Missing (in isoform 4); 272..386; GVFSFEAGRRCHSGEGLFAFSTPCAPDLCRAVAGAIARQRERLPELTRPQPCPLPRATSLPSLDTPGELREMPPGPEPPTSRKMHLAEPGPQSLPLLLGPEPNDLASGLYASVCK -> ILLGTPGVSLLICKGERTDDVSGIILDESLLRAYSVPGAGGHSRVQDSLGPVLREPTFQGERSFLKTSMLRSLLCSCSWRHPRSQPRTQASCLQGSDCPAPHRNSTSAAHTLGTS (in isoform 2, isoform 3 and isoform 4); 387..496; Missing (in isoform 2, isoform 3 and isoform 4)

Domain & Motif Annotations

Domain (CC)

PTB domain mediates receptor interaction.

Domain (FT)

63..179; PH; 213..317; IRS-type PTB

Region

18..38; Disordered; 313..363; Disordered; 408..447; Disordered

Protein Families (2)

DOK family
Type A subfamily

Sequence Similarities

Belongs to the DOK family. Type A subfamily.

Clinical Relevance

Antibody

HPA077312

Interaction Protein

ENSG00000146648

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications2

PMID	Title	Related sentences
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No related sentences available
41068253	Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression.	No related sentences available