Protein detail
TAOK1
Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Kinase from chicken homolog B) (hKFC-B) (MARK Kinase) (MARKK) (Prostate-derived sterile 20-like kinase 2) (PSK-2) (PSK2) (Prostate-derived STE20-like kinase 2) (Thousand and one amino acid protein kinase 1) (TAOK1) (hTAOK1)
Protein symbol TAOK1 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Disease related genesEnzymesHuman disease related genesPotential drug targetsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Kinase from chicken homolog B) (hKFC-B) (MARK Kinase) (MARKK) (Prostate-derived sterile 20-like kinase 2) (PSK-2) (PSK2) (Prostate-derived STE20-like kinase 2) (Thousand and one amino acid protein kinase 1) (TAOK1) (hTAOK1)
Protein Class
Disease related genesEnzymesHuman disease related genesPotential drug targetsPredicted intracellular proteins
Protein Function
- Human disease related genes:Other diseases:Mental and behavioural disorders
- Kinases:STE Ser/Thr protein kinases
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym
FLJ14314hKFC-BhTAOK1KIAA1361MAP3K16MARKKPSK2TAO1
Gene Description
TAO kinase 1
Chromosome
17
Position
29390363-29551903
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificBreast myoepithelial cells
Function & Pathway
Protein Function
- Human disease related genes:Other diseases:Mental and behavioural disorders
- Kinases:STE Ser/Thr protein kinases
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Disease related genes
Cellular Component
Molecular Function
- GO:0004672 protein kinase activity
- GO:0004674 protein serine/threonine kinase activity
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0016301 kinase activity
- GO:0016740 transferase activity
- GO:0043014 alpha-tubulin binding
- GO:0043539 protein serine/threonine kinase activator activity
- GO:0044024 histone H2AS1 kinase activity
- GO:0048156 tau protein binding
- GO:0048487 beta-tubulin binding
- GO:0050321 tau-protein kinase activity
- GO:0106310 protein serine kinase activity
Reactome
- R-hsa-1640170 cell cycle
- R-hsa-69620 cell cycle checkpoints
- R-hsa-69278 cell cycle mitotic
- R-hsa-9918481 dengue virus host interactions
- R-hsa-9839923 dengue virus infection
- R-hsa-9920951 dengue virus modulates apoptosis
- R-hsa-5663205 infectious disease
- R-hsa-2555396 mitotic metaphase and anaphase
- R-hsa-68877 mitotic prometaphase
- R-hsa-69618 mitotic spindle checkpoint
- R-hsa-68886 m phase
- R-hsa-2500257 resolution of sister chromatid cohesion
- R-hsa-5663220 rho gtpases activate formins
- R-hsa-195258 rho gtpase effectors
- R-hsa-2467813 separation of sister chromatids
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
- R-hsa-9824446 viral infection pathways
Mediation Categories
Clinical-translation mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
4 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| TAOK1 | ATM | Q13315 | S | 990 | phosphorylation | PhosphoSite_MIMPMIMPNCI-PID_ProtMapperSIGNORProtMapperKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:17396146KEA:17396146ProtMapper:10848581SIGNOR:17396146 |
| TAOK1 | ATM | Q13315 | T | 785 | phosphorylation | PhosphoSite_MIMPMIMPNCI-PID_ProtMapperSIGNORProtMapperKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:17396146KEA:17396146ProtMapper:10848581SIGNOR:17396146 |
| TAOK1 | ATM | Q13315 | T | 643 | phosphorylation | PhosphoSite_MIMPMIMPNCI-PID_ProtMapperSIGNORProtMapperKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:17396146KEA:17396146ProtMapper:10848581SIGNOR:17396146 |
| TAOK1 | STK24 | Q9Y6E0 | T | 440 | phosphorylation | PhosphoSite |
Ligand-Receptor Signaling
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Regulatory Interaction Network
6 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| TAOK1 | Q7L7X3 | MP2K3 | P46734 | Yes | Yes | No | WangNCI-PID_ProtMapperiPTMnetSIGNORProtMapperHPRDSignaLink3ACSNSIGNOR_ProtMapper | HPRD:9786855SIGNOR:9786855HPRD:10497253ProtMapper:17396146SignaLink3:9786855SignaLink3:23331499ACSN:18855897ProtMapper:9786855ACSN:21614932ACSN:11274345ACSN:12738796 |
| ATM | Q13315 | TAOK1 | Q7L7X3 | Yes | Yes | No | WangPhosphoSite_MIMPMIMPNCI-PID_ProtMapperPhosphoSite_norefSIGNORiPTMnetProtMapperKinexus_KEAKEAACSNSIGNOR_ProtMapperPhosphoSite_ProtMapper | ACSN:20506250ACSN:15140942KEA:17396146ProtMapper:17396146SIGNOR:17396146ACSN:18855897ACSN:21614932ProtMapper:10848581 |
| TAOK1 | Q7L7X3 | MARK2 | Q7KZI7 | Yes | Yes | No | dbPTMiPTMnetSIGNOR | SIGNOR:18424437dbPTM:14976552dbPTM:17192257dbPTM:19369195 |
| TAOK1 | Q7L7X3 | STK4 | Q13043 | Yes | Yes | No | REACH_ProtMapperSIGNORProtMapper | SIGNOR:23431053ProtMapper:29673168 |
| TAOK1 | Q7L7X3 | STK3 | Q13188 | Yes | Yes | No | iPTMnetREACH_ProtMapperSIGNORProtMapper | SIGNOR:23431053ProtMapper:29673168 |
| STK24 | Q9Y6E0 | TAOK1 | Q7L7X3 | Yes | No | No | PhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:25456499 |
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
1,001
Mass
116,070
Sequence
MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRERPETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGSNQSIPSMSISASSQSSSVNSLPDVSDDKSELDMMEGDHTVMSNSSVIHLKPEEENYREEGDPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTRQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSLRRALLEQKIEEEMLALQNERTERIRSLLERQAREIEAFDSESMRLGFSNMVLSNLSPEAFSHSYPGASGWSHNPTGGPGPHWGHPMGGPPQAWGHPMQGGPQPWGHPSGPMQGVPRGSSMGVRNSPQALRRTASGGRTEQGMSRSTSVTSQISNGSHMSYT
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q7L7X3-1; Sequence=Displayed; Name=2; IsoId=Q7L7X3-2; Sequence=VSP_015964, VSP_015965, VSP_015966; Name=3; IsoId=Q7L7X3-3; Sequence=VSP_043706
Alternative Sequence
1..174; Missing (in isoform 2); 569..716; Missing (in isoform 3); 569..572; ELNE -> VLMS (in isoform 2); 573..1001; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
350..373; Low complexity; 375..388; Basic and acidic residues; 399..416; Basic and acidic residues; 577..587; Basic and acidic residues; 975..1001; Polar residues
Coiled Coil
458..651; 754..877
Domain (FT)
28..281; Protein kinase
Region
324..433; Disordered; 567..587; Disordered; 911..1001; Disordered
Protein Families
- Protein kinase superfamily
- STE Ser/Thr protein kinase family
- STE20 subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Clinical Relevance
Disease Involvement
Disease variantIntellectual disability
Drugs
PHA-767491CHEMBL:CHEMBL379975AST-487LY-2090314TOZASERTIBCENISERTIBPAZOPANIBNVP-TAE684PD-0166285SP-600125CP-547632PALBOCICLIBPF-562271SOTRASTAURINLADUVIGLUSIBTAMATINIBDASATINIB ANHYDROUSILORASERTIBADAVOSERTIBRG-1530SORAFENIBR-1487ENTRECTINIBCEDIRANIBJNJ-7706621CHEMBL:CHEMBL1997335CYC-116BMS-387032LINIFANIBIMATINIBBMS-345541