Protein detail

S36A1

Proton-coupled amino acid transporter 1 (Proton/amino acid transporter 1) (hPAT1) (Solute carrier family 36 member 1)

Entry name
S36A1
UniProt ID
Q7Z2H8
EVMP confidence score
0.35
Supporting publications (n)
0
Transmembrane count
11
Protein classification
Metabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Basic Information
Protein Names
Proton-coupled amino acid transporter 1 (Proton/amino acid transporter 1) (hPAT1) (Solute carrier family 36 member 1)
Protein Class (4)
Metabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (2)
  • Transporters:Electrochemical Potential-driven transporters
  • Predicted intracellular proteins
Transmembrane
52..72; Helical; Name=1; 79..99; Helical; Name=2; 142..162; Helical; Name=3; 191..211; Helical; Name=4; 216..236; Helical; Name=5; 258..278; Helical; Name=6; 290..310; Helical; Name=7; 343..363; Helical; Name=8; 373..393; Helical; Name=9; 398..418; Helical; Name=10; 440..460; Helical; Name=11
Transmembrane Count
11
Ensembl
ENSG00000123643
Entrez Gene Symbol
SLC36A1
Gene Synonym (3)
LYAAT-1PAT1TRAMD3
Gene Description
Solute carrier family 36 member 1
Chromosome
5
Position
151437046-151492379
Supporting publications (n)
0
EVMP confidence score
0.35
Fluorescence & Localization
Tissue SpecificcervixCell SpecificEsophageal apical cellsSecretome LocationSecreted in other tissuesSecretome FunctionReceptor
Function & Pathway
Protein Function (2)
  • Transporters:Electrochemical Potential-driven transporters
  • Predicted intracellular proteins
Cellular Component (5)
Molecular Function (9)
Biological Process (3)
KEGG (2)
Reactome (3)
Canonical Pathways (3)
  • M235 Pid tcr calcium pathway
  • M290 Pid il12 stat4 pathway
  • M113 Pid nfat 3pathway
Mediation Categories
Fusion and delivery mediation
Relations & Evidence27

Ligand-Receptor Signaling (26)

26 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
slctransporterSurfaceomeYes
transportertransporterOmniPathYes
transmembranetransmembraneUniProt_location
transmembranetransmembraneUniProt_topology
transmembranetransmembraneUniProt_keyword
transmembranetransmembraneTopDB
transmembranetransmembraneLOCATE
transmembranetransmembraneRamilowski_location
transmembranetransmembraneOmniPath
plasma_membraneplasma_membraneUniProt_location
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Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyMicrofluidics-Based MethodsMass spectrometry [LTQ-FT Ultra]Mass spectrometry732938681317537264116790429603567246701523086538136028467
Sequence, Structure & Domains

Sequences

Length
476
Mass
53,076
Sequence
MSTQRLRNEDYHDYSSTDVSPEESPSEGLNNLSSPGSYQRFGQSNSTTWFQTLIHLLKGNIGTGLLGLPLAVKNAGIVMGPISLLIIGIVAVHCMGILVKCAHHFCRRLNKSFVDYGDTVMYGLESSPCSWLRNHAHWGRRVVDFFLIVTQLGFCCVYFVFLADNFKQVIEAANGTTNNCHNNETVILTPTMDSRLYMLSFLPFLVLLVFIRNLRALSIFSLLANITMLVSLVMIYQFIVQRIPDPSHLPLVAPWKTYPLFFGTAIFSFEGIGMVLPLENKMKDPRKFPLILYLGMVIVTILYISLGCLGYLQFGANIQGSITLNLPNCWLYQSVKLLYSIGIFFTYALQFYVPAEIIIPFFVSRAPEHCELVVDLFVRTVLVCLTCILAILIPRLDLVISLVGSVSSSALALIIPPLLEVTTFYSEGMSPLTIFKDALISILGFVGFVVGTYEALYELIQPSNAPIFINSTCAFI
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q7Z2H8-1; Sequence=Displayed; Name=2; IsoId=Q7Z2H8-3; Sequence=VSP_044392; Name=3; IsoId=Q7Z2H8-4; Sequence=VSP_044390, VSP_044391
Alternative Sequence
242..243; RI -> IL (in isoform 3); 244..476; Missing (in isoform 3); 387..476; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias
1..15; Basic and acidic residues
Region
1..32; Disordered
Protein Families
Amino acid/polyamine transporter 2 family
Sequence Similarities
Belongs to the amino acid/polyamine transporter 2 family.
Clinical Relevance
Antibody
HPA035937