Protein detail

SDK1

Protein sidekick-1

Entry name SDK1	UniProt ID Q7Z5N4	EVMP confidence score 0.25
Supporting publications (n) 4	Transmembrane count 1	Protein classification Predicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Protein sidekick-1

Protein Class (2)

Predicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins

Transmembrane

2010..2030; Helical

Transmembrane Count

Ensembl

ENSG00000146555

Entrez Gene Symbol

SDK1

Gene Synonym

FLJ31425

Gene Description

Sidekick cell adhesion molecule 1

Chromosome

Position

3301252-4269000

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization2

Cell SpecificOocytes

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (2)

Molecular Function

GO:0042802 identical protein binding

Biological Process (3)

Reactome (2)

Mediation Categories (2)

Adhesion and uptake mediationReceptor-signaling mediation

Relations & Evidence24

Ligand-Receptor Signaling (23)

23 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No

Page 3 of 3Previous

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryMass spectrometry [LTQ-FT Ultra]	33	40189497 37926756 36064647 26098714 38113368 40465195 37322475 33304478 36497184 34064677 33592500 32854315 40985879 38014595 27487081 34473505 38891077 30915084 32560723 32916986 41307968 36146834 33309826 40840701 37670049 38607062 32230970 38207106 34576246 37204515 39001700 39207047 41068253

Sequence, Structure & Domains12

Sequences

Length

2,213

Mass

242,112

Sequence

MARGARPSAAGGGGGGAEPPERAGPGRPRGSPPGRARPSLAPRPGPEPSRPRAAPETSGGDTAGAGRCGGRRAAKLGPGRRGWWALLALQLHLLRALAQDDVAPYFKTEPGLPQIHLEGNRLVLTCLAEGSWPLEFKWMRDDSELTTYSSEYKYIIPSLQKLDAGFYRCVVRNRMGALLQRKSEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPITSYPRPQVTWFREGHKIIPSNRIAITLENQLVILATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRNGVRITSGLHSFGRRLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQARTITYGPELQANITAGPAEGSPGSPRDVLVTKSASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPSTAVSAQVEAPFYEEWWFLLVMALSSLIVILLVVFALVLHGQNKKYKNCSTGKGISTMEESVTLDNGGFAALELSSRHLNVKSTFSKKNGTRSPPRPSPGGLHYSDEDICNKYNGAVLTESVSLKEKSADASESEATDSDYEDALPKHSFVNHYMSDPTYYNSWKRRAQGRAPAPHRYEAVAGSEAGAQLHPVITTQSAGGVYTPAGPGARTPLTGFSSFV

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q7Z5N4-1; Sequence=Displayed; Name=2; IsoId=Q7Z5N4-2; Sequence=VSP_017517, VSP_017519; Name=3; IsoId=Q7Z5N4-3; Sequence=VSP_017518

Alternative Sequence

1..1940; Missing (in isoform 2); 1643..1662; Missing (in isoform 3); 1941..1942; PS -> ME (in isoform 2)

Domain & Motif Annotations

Compositional Bias

23..38; Low complexity

Motif

2207..2213; PDZ-binding

Domain (CC)

Ig-like C2-type domains 1 and 2 mediate homophilic interactions.

Domain (FT)

104..186; Ig-like C2-type 1; 191..277; Ig-like C2-type 2; 293..378; Ig-like C2-type 3; 386..476; Ig-like C2-type 4; 480..569; Ig-like C2-type 5; 574..663; Ig-like C2-type 6; 670..766; Fibronectin type-III 1; 771..867; Fibronectin type-III 2; 872..970; Fibronectin type-III 3; 974..1068; Fibronectin type-III 4; 1072..1171; Fibronectin type-III 5; 1176..1274; Fibronectin type-III 6; 1279..1376; Fibronectin type-III 7; 1380..1474; Fibronectin type-III 8; 1479..1576; Fibronectin type-III 9; 1581..1699; Fibronectin type-III 10; 1704..1800; Fibronectin type-III 11; 1804..1899; Fibronectin type-III 12; 1902..2000; Fibronectin type-III 13

Region

1..73; Disordered; 2075..2098; Disordered

Protein Families

Sidekick family

Sequence Similarities

Belongs to the sidekick family.

Clinical Relevance2

Drugs

NULL

Antibody

HPA011392

Supporting Publications4

PMID	Title	Abstract
24670152	Quantitative proteomics of extracellular vesicles released from human monocyte-derived macrophages upon β-glucan stimulation.	No abstract available
30865381	Surfaceome of Exosomes Secreted from the Colorectal Cancer Cell Line SW480: Peripheral and Integral Membrane Proteins Analyzed by Proteolysis and TX114.	No abstract available
32301581	Proteomic and biological profiling of extracellular vesicles from Alzheimer's disease human brain tissues.	Extracellular vesicles (EVs) from human Alzheimer's disease (AD) biospecimens contain amyloid beta (Aβ) peptide and tau.
32938681	Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis.	No abstract available