Protein detail
AB1IP
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Rap1-GTP-interacting adapter molecule) (RIAM) (Retinoic acid-responsive proline-rich protein 1) (RARP-1)
Entry name AB1IP | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Rap1-GTP-interacting adapter molecule) (RIAM) (Retinoic acid-responsive proline-rich protein 1) (RARP-1)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
INAG1RIAM
Gene Description
Amyloid beta precursor protein binding family B member 1 interacting protein
Chromosome
10
Position
26438341-26567803
Supporting publications (n)
1
EVMP confidence score
0.50
Function & Pathway7
Protein Function
Predicted intracellular proteins
Cellular Component (6)
Molecular Function
Biological Process (3)
Reactome (13)
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-354194 grb2 sos provides linkage to mapk signaling for integrins
- R-hsa-109582 hemostasis
- R-hsa-354192 integrin signaling
- R-hsa-5674135 map2k and mapk activation
- R-hsa-5684996 mapk1 mapk3 signaling
- R-hsa-5683057 mapk family signaling cascades
- R-hsa-6802957 oncogenic mapk signaling
- R-hsa-372708 p130cas linkage to mapk signaling for integrins
- R-hsa-76002 platelet activation signaling and aggregation
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Mediation Categories (4)
Adhesion and uptake mediationClinical-translation mediationImmune mediationReceptor-signaling mediation
Relations & Evidence8
Ligand-Receptor Signaling (7)
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Isolation & Detection Technology (1)
Sequence, Structure & Domains14
Sequences
Length
666
Mass
73,183
Sequence
MGESSEDIDQMFSTLLGEMDLLTQSLGVDTLPPPDPNPPRAEFNYSVGFKDLNESLNALEDQDLDALMADLVADISEAEQRTIQAQKESLQNQHHSASLQASIFSGAASLGYGTNVAATGISQYEDDLPPPPADPVLDLPLPPPPPEPLSQEEEEAQAKADKIKLALEKLKEAKVKKLVVKVHMNDNSTKSLMVDERQLARDVLDNLFEKTHCDCNVDWCLYEIYPELQIERFFEDHENVVEVLSDWTRDTENKILFLEKEEKYAVFKNPQNFYLDNRGKKESKETNEKMNAKNKESLLEESFCGTSIIVPELEGALYLKEDGKKSWKRRYFLLRASGIYYVPKGKTKTSRDLACFIQFENVNIYYGTQHKMKYKAPTDYCFVLKHPQIQKESQYIKYLCCDDTRTLNQWVMGIRIAKYGKTLYDNYQRAVAKAGLASRWTNLGTVNAAAPAQPSTGPKTGTTQPNGQIPQATHSVSAVLQEAQRHAETSKDKKPALGNHHDPAVPRAPHAPKSSLPPPPPVRRSSDTSGSPATPLKAKGTGGGGLPAPPDDFLPPPPPPPPLDDPELPPPPPDFMEPPPDFVPPPPPSYAGIAGSELPPPPPPPPAPAPAPVPDSARPPPAVAKRPPVPPKRQENPGHPGGAGGGEQDFMSDLMKALQKKRGNVS
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7Z5R6-1; Sequence=Displayed; Name=2; IsoId=Q7Z5R6-2; Sequence=VSP_056542, VSP_056543
Alternative Sequence
152..172; EEEEAQAKADKIKLALEKLKE -> VSMWDQRWQDHQPLLPITDVP (in isoform 2); 173..666; Missing (in isoform 2)
3D Structural Models
Turn
26..31
Helix
8..25
3D Structure
NMR spectroscopy (1); X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
129..148; Pro residues; 453..478; Polar residues; 483..504; Basic and acidic residues; 547..589; Pro residues; 598..631; Pro residues
Domain (CC)
The two Pro-rich regions are required for the suppression of AP1 transcription activity.
Domain (FT)
176..263; Ras-associating; 310..419; PH
Region
122..155; Disordered; 448..666; Disordered
Protein Families
MRL family
Sequence Similarities
Belongs to the MRL family.
Clinical Relevance5
Drugs
Interaction Protein
ENSG00000186908
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 39123364 | Growth Hormone Upregulates Melanoma Drug Resistance and Migration via Melanoma-Derived Exosomes. | The GH-treated melanoma cells released exosomes with elevated levels of ABC transporters (ABCC1 and ABCB1), N-cadherin, and MMP2, enhancing drug resistance and migration in the recipient cells. |