Protein detail

WDR53

WD repeat-containing protein 53

Entry name WDR53	UniProt ID Q7Z5U6	EVMP confidence score 0.38
Supporting publications (n) 3	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

WD repeat-containing protein 53

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000185798

Entrez Gene Symbol

WDR53

Gene Synonym (2)

MGC12928MGC64882

Gene Description

WD repeat domain 53

Chromosome

Position

196554177-196568674

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization2

Cell SpecificMicroglia

Function & Pathway4

Protein Function

Predicted intracellular proteins

Biological Process (3)

Canonical Pathways (3)

M134 Pid tcr ras pathway
M37 Pid nfkappab canonical pathway
M226 Pid vegfr1 pathway

Mediation Categories

Other mediation

Relations & Evidence6

Ligand-Receptor Signaling (2)

2 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (3)

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database
EIF5 NACA NEMF SYAP1 WDR53	E9PAV3 O60524 P55010 Q7Z5U6 Q96A49	0:0:0:0:0	hu.MAP2
EIF5 NACA NEMF SYAP1 WDR53	O60524 P55010 Q13765 Q7Z5U6 Q96A49	0:0:0:0:0	hu.MAP2
RSAD1 WDR53	Q7Z5U6 Q9HA92	0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryMass spectrometry [QTOF]	34	40985879 36064647 38113368 28680152 40465195 35119778 37322475 33304478 36497184 34064677 26826536 40189497 32357574 33592500 32854315 38014595 38891077 30915084 41307968 36146834 35763629 27821849 40840701 31805958 38607062 32230970 30875722 38207106 38716512 34576246 37204515 36982312 39207047 37670049

Sequence, Structure & Domains8

Sequences

Length

358

Mass

38,989

Sequence

MAVKWTGGHSSPVLCLNASKEGLLASGAEGGDLTAWGEDGTPLGHTRFQGADDVTSVLFSPSCPTKLYASHGETISVLDVRSLKDSLDHFHVNEEEINCLSLNQTENLLASADDSGAIKILDLENKKVIRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQVMLWSLQKARPLWITNLQEDETEEMEGPQSPGQLLNPALAHSISVASCGNIFSCGAEDGKVRIFRVMGVKCEQELGFKGHTSGVSQVCFLPESYLLLTGGNDGKITLWDANSEVEKKQKSPTKRTHRKKPKRGTCTKQGGNTNASVTDEEEHGNILPKLNIEHGEKVNWLLGTKIKGHQNILVADQTSCISVYPLNEF

Domain & Motif Annotations

Compositional Bias

279..294; Basic residues; 295..306; Polar residues

Repeat

1..38; WD 1; 43..80; WD 2; 85..123; WD 3; 127..166; WD 4; 173..225; WD 5; 232..270; WD 6; 314..355; WD 7

Region

273..311; Disordered

Protein Families

WD repeat WDR53 family

Sequence Similarities

Belongs to the WD repeat WDR53 family.

Clinical Relevance1

Antibody

HPA016420

Supporting Publications3

PMID	Title	Abstract
37922300	Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women.	No abstract available
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No abstract available