Protein detail
WDR53
WD repeat-containing protein 53
Entry name WDR53 | UniProt ID | EVMP score 0.38 |
Frequency 3 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
WD repeat-containing protein 53
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
MGC12928MGC64882
Gene Description
WD repeat domain 53
Chromosome
3
Position
196554177-196568674
Frequency
3
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificMicroglia
Function & Pathway
Protein Function
Predicted intracellular proteins
Biological Process
Canonical Pathways
- M134 Pid tcr ras pathway
- M37 Pid nfkappab canonical pathway
- M226 Pid vegfr1 pathway
Mediation Categories
Other mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
2 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture | Mass spectrometryMass spectrometry [QTOF] | 34 | 40985879360646473811336828680152404651953511977837322475333044783649718434064677268265364018949732357574335925003285431538014595388910773091508441307968361468343576362927821849408407013180595838607062322309703087572238207106387165123457624637204515369823123920704737670049 |
Sequence, Structure & Domains
Sequences
Length
358
Mass
38,989
Sequence
MAVKWTGGHSSPVLCLNASKEGLLASGAEGGDLTAWGEDGTPLGHTRFQGADDVTSVLFSPSCPTKLYASHGETISVLDVRSLKDSLDHFHVNEEEINCLSLNQTENLLASADDSGAIKILDLENKKVIRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQVMLWSLQKARPLWITNLQEDETEEMEGPQSPGQLLNPALAHSISVASCGNIFSCGAEDGKVRIFRVMGVKCEQELGFKGHTSGVSQVCFLPESYLLLTGGNDGKITLWDANSEVEKKQKSPTKRTHRKKPKRGTCTKQGGNTNASVTDEEEHGNILPKLNIEHGEKVNWLLGTKIKGHQNILVADQTSCISVYPLNEF
3D Structural Models
Domain & Motif Annotations
Compositional Bias
279..294; Basic residues; 295..306; Polar residues
Repeat
1..38; WD 1; 43..80; WD 2; 85..123; WD 3; 127..166; WD 4; 173..225; WD 5; 232..270; WD 6; 314..355; WD 7
Region
273..311; Disordered
Protein Families
WD repeat WDR53 family
Sequence Similarities
Belongs to the WD repeat WDR53 family.
Clinical Relevance
Antibody