Protein detail
GP142
G protein-coupled receptor 142 (G protein-coupled receptor PGR2)
Entry name GP142 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 7 | Protein classification G-protein coupled receptorsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
G protein-coupled receptor 142 (G protein-coupled receptor PGR2)
Protein Class (2)
G-protein coupled receptorsPredicted membrane proteins
Protein Function
G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
153..173; Helical; Name=1; 196..216; Helical; Name=2; 234..254; Helical; Name=3; 279..299; Helical; Name=4; 317..337; Helical; Name=5; 358..378; Helical; Name=6; 398..418; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
PGR2
Gene Description
G protein-coupled receptor 142
Chromosome
17
Position
74367458-74372600
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization3
Tissue Specificadipose tissueCell SpecificAdipocytesSingle-Nuclei Brain Specificastrocyte
Function & Pathway6
Protein Function
G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component (3)
Molecular Function
Biological Process (3)
Canonical Pathways (2)
- M125 Pid igf1 pathway
- M15 Pid lysophospholipid pathway
Mediation Categories
Other mediation
Relations & Evidence37
Ligand-Receptor Signaling (36)
36 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| class_a_rhodopsin_orphan | receptor | GPCRdb | No | Yes | No | Yes | No |
| class_a_rhodopsin_orphan_class_a_orphans | receptor | GPCRdb | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | HPMR | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 36759883 |
Sequence, Structure & Domains9
Sequences
Length
462
Mass
51,106
Sequence
MSIMMLPMEQKIQWVPTSLQDITAVLGTEAYTEEDKSMVSHAQKSQHSCLSHSRWLRSPQVTGGSWDLRIRPSKDSSSFRQAQCLRKDPGANNHLESQGVRGTAGDADRELRGPSEKATAGQPRVTLLPTPHVSGLSQEFESHWPEIAERSPCVAGVIPVIYYSVLLGLGLPVSLLTAVALARLATRTRRPSYYYLLALTASDIIIQVVIVFAGFLLQGAVLARQVPQAVVRTANILEFAANHASVWIAILLTVDRYTALCHPLHHRAASSPGRTRRAIAAVLSAALLTGIPFYWWLDMWRDTDSPRTLDEVLKWAHCLTVYFIPCGVFLVTNSAIIHRLRRRGRSGLQPRVGKSTAILLGITTLFTLLWAPRVFVMLYHMYVAPVHRDWRVHLALDVANMVAMLHTAANFGLYCFVSKTFRATVRQVIHDAYLPCTLASQPEGMAAKPVMEPPGLPTGAEV
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7Z601-1; Sequence=Displayed; Name=2; IsoId=Q7Z601-2; Sequence=VSP_062733
Alternative Sequence
1..118; MSIMMLPMEQKIQWVPTSLQDITAVLGTEAYTEEDKSMVSHAQKSQHSCLSHSRWLRSPQVTGGSWDLRIRPSKDSSSFRQAQCLRKDPGANNHLESQGVRGTAGDADRELRGPSEKA -> MLTGSCGDPQKKPQVTQDSGPQSMGLEGRE (in isoform 2)
Domain & Motif Annotations
Compositional Bias
106..115; Basic and acidic residues
Region
87..123; Disordered
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance1
Antibody
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 36573687 | Proteomic and phosphoproteomic landscape of salivary extracellular vesicles to assess OSCC therapeutical outcomes. | No abstract available |