Protein detail
BTLA
B- and T-lymphocyte attenuator (B- and T-lymphocyte-associated protein) (CD antigen CD272)
Protein symbol BTLA | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 1 | Protein classification CD markersPredicted membrane proteinsPredicted secreted proteins |
Basic Information
Protein Names
B- and T-lymphocyte attenuator (B- and T-lymphocyte-associated protein) (CD antigen CD272)
Protein Class
CD markersPredicted membrane proteinsPredicted secreted proteins
Protein Function
- Predicted secreted proteins
- CD markers
Transmembrane
158..178; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
BTLA1CD272
Gene Description
B and T lymphocyte associated
Chromosome
3
Position
112463966-112499472
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Tissue SpecificretinaCell SpecificBasal keratinocytes
Function & Pathway
Protein Function
- Predicted secreted proteins
- CD markers
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Clinical-translation mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
Ligand-Receptor Signaling
35 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | connectomeDB2020 | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| receptor | receptor | connectomeDB2020 | No | Yes | No | Yes | No |
| receptor | receptor | iTALK | No | Yes | No | Yes | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| LCK | P06239 | BTLA | Q7Z6A9 | Yes | No | No | PhosphoSite_norefPhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:32437509 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 39408670 |
Sequence, Structure & Domains
Sequences
Length
289
Mass
32,834
Sequence
MKTLPAMLGTGKLFWVFFLIPYLDIWNIHGKESCDVQLYIKRQSEHSILAGDPFELECPVKYCANRPHVTWCKLNGTTCVKLEDRQTSWKEEKNISFFILHFEPVLPNDNGSYRCSANFQSNLIESHSTTLYVTDVKSASERPSKDEMASRPWLLYRLLPLGGLPLLITTCFCLFCCLRRHQGKQNELSDTAGREINLVDAHLKSEQTEASTRQNSQVLLSETGIYDNDPDLCFRMQEGSEVYSNPCLEENKPGIVYASLNHSVIGPNSRLARNVKEAPTEYASICVRS
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7Z6A9-1; Sequence=Displayed; Name=2; IsoId=Q7Z6A9-2; Sequence=VSP_040305
Alternative Sequence
135..182; Missing (in isoform 2)
3D Structural Models
Helix
107..109
Beta Strand
44..49; 54..61; 63..65; 70..75; 78..81; 87..92; 95..102; 111..119; 122..125; 129..134
3D Structure
X-ray crystallography (5)
Domain & Motif Annotations
Domain (FT)
31..132; Ig-like V-type
Clinical Relevance
Related Diseases
Biomarker
Phase 2; Phase 1