Protein detail

PTAR1

Protein prenyltransferase alpha subunit repeat-containing protein 1

Entry name PTAR1	UniProt ID Q7Z6K3	EVMP confidence score 0.50
Supporting publications (n) 7	Transmembrane count	Protein classification Predicted intracellular proteins

Basic Information

Protein Names

Protein prenyltransferase alpha subunit repeat-containing protein 1

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000188647

Entrez Gene Symbol

PTAR1

Gene Description

Protein prenyltransferase alpha subunit repeat containing 1

Chromosome

Position

69709522-69760011

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization

Tissue Specificbone marrowCell SpecificLate spermatidsBlood Cell SpecificeosinophilBlood Lineage Specificgranulocytes

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component (2)

Molecular Function (2)

Biological Process (3)

Canonical Pathways

M33 Pid glypican 1pathway

Mediation Categories

Other mediation

Relations & Evidence8

Ligand-Receptor Signaling (3)

3 records.

Category	Parent	Database
intracellular	intracellular	ComPPI
intracellular	intracellular	GO_Intercell
intracellular	intracellular	OmniPath

Protein Complex Composition (4)

4 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
PTAR1 RABGGTB YKT6	O15498 P53611 Q7Z6K3	1:1:1	PDB	PDB:6j7xPDB:6j74PDB:6j7f
PTAR1 YKT6	O15498 Q7Z6K3	0:0	hu.MAP2
PTAR1 RFK YKT6	O15498 Q7Z6K3 Q969G6	0:0:0	hu.MAP2
PTAR1 RABGGTB	P53611 Q7Z6K3	1:1	hu.MAP2PDB	PDB:6j6x

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	40689422

Sequence, Structure & Domains

Sequences

Length

402

Mass

46,405

Sequence

MAETSEEVAVLVQRVVKDITNAFRRNPHIDEIGLIPCPEARYNRSPIVLVENKLGVESWCVKFLLPYVHNKLLLYRTRKQWLNRDELIDVTCTLLLLNPDFTTAWNVRKELILSGTLNPIKDLHLGKLALTKFPKSPETWIHRRWVLQQLIQETSLPSFVTKGNLGTIPTERAQRLIQEEMEVCGEAAGRYPSNYNAWSHRIWVLQHLAKLDVKILLDELSSTKHWASMHVSDHSGFHYRQFLLKSLISQTVIDSSVMEQNPLRSEPALVPPKDEEAAVSTEEPRINLPHLLEEEVEFSTDLIDSYPGHETLWCHRRHIFYLQHHLNAGSQLSQAMEVDGLNDSSKQGYSQETKRLKRTPVPDSLGLEMEHRFIDQVLSTCRNVEQARFASAYRKWLVTLSQ

3D Structural Models

Turn

150..153; 281..283; 284..286

Helix

7..25; 58..60; 61..76; 84..97; 102..113; 119..132; 137..149; 172..190; 195..207; 213..229; 234..248; 290..305; 310..323; 368..379; 384..397

Beta Strand

31..35; 42..44; 46..50; 53..57; 209..211

3D Structure

X-ray crystallography (5)

Domain & Motif Annotations

Repeat

81..115; PFTA 1; 116..152; PFTA 2; 171..210; PFTA 3; 211..250; PFTA 4; 289..325; PFTA 5; 366..400; PFTA 6

Region

263..282; Disordered

Protein Families

Protein prenyltransferase subunit alpha family

Sequence Similarities

Belongs to the protein prenyltransferase subunit alpha family.

Clinical Relevance

Antibody (2)

HPA021248 HPA022781

Interaction Protein

ENSG00000137955

Interaction Count

Interaction Dataset

biogrid_opencell_bioplex

Supporting Publications7

PMID	Title	Related sentences
24505114	Proteomics analysis of cancer exosomes using a novel modified aptamer-based array (SOMAscan™) platform.	These included proteins of known association with cancer exosomes such as MFG-E8, integrins, and MET, and also those less widely reported as exosomally associated, such as ROR1 and ITIH4.
28963552	Radiation alters the cargo of exosomes released from squamous head and neck cancer cells to promote migration of recipient cells.	No related sentences available
30608700	Quantitative Proteomic Analysis of Small and Large Extracellular Vesicles (EVs) Reveals Enrichment of Adhesion Proteins in Small EVs.	No related sentences available
31588238	Dual-platform affinity proteomics identifies links between the recurrence of ovarian carcinoma and proteins released into the tumor microenvironment.	No related sentences available
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No related sentences available
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No related sentences available
40784529	Serum-derived exosome proteomics unveils the distinct and adjustable nature of the dampness constitution in traditional Chinese medicine.	No related sentences available