Protein detail

K2C1B

Keratin, type II cytoskeletal 1b (Cytokeratin-1B) (CK-1B) (Keratin-77) (K77) (Type-II keratin Kb39)

Protein symbol K2C1B	UniProt ID Q7Z794	EVMP score 0.38
Frequency 1	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Keratin, type II cytoskeletal 1b (Cytokeratin-1B) (CK-1B) (Keratin-77) (K77) (Type-II keratin Kb39)

Protein Class

Plasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000189182

Entrez Gene Symbol

KRT77

Gene Synonym

KRT1B

Gene Description

Keratin 77

Chromosome

Position

52689626-52703524

Frequency

EVMP Score

0.38

Fluorescence & Localization

Cell SpecificFibro-adipogenic progenitorsSingle-Nuclei Brain Specificastrocyte

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

KEGG

Reactome

Mediation Categories

Other mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	GO_Intercell	Yes	No	No	No	No
ecm	ecm	OmniPath	Yes	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	DSP KRT1 KRT17 KRT5 KRT6A KRT77	P02538 P04264 P13647 P15924 Q04695 Q7Z794	0:0:0:0:0:0	hu.MAP2
	DSP KRT1 KRT5 KRT77	P04264 P13647 P15924 Q7Z794	0:0:0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometryMass spectrometry [LTQ-FT Ultra]	1	37762473

Sequence, Structure & Domains

Sequences

Length

578

Mass

61,901

Sequence

MSHQFSSQSAFSSMSRRVYSTSSSAGSGGGSPAVGSVCYARGRCGGGGYGIHGRGFGSRSLYNLGGSRSISINLMGRSTSGFCQGGGVGGFGGGRGFGVGSTGAGGFGGGGFGGAGFGTSNFGLGGFGPYCPPGGIQEVTINQSLLEPLHLEVDPEIQRIKTQEREQIMVLNNKFASFIDKVRFLEQQNQVLQTKWELLQQVNTSTGTNNLEPLLENYIGDLRRQVDLLSAEQMRQNAEVRSMQDVVEDYKSKYEDEINKRTGSENDFVVLKKDVDAAYVSKVDLESRVDTLTGEVNFLKYLFLTELSQVQTHISDTNVILSMDNNRSLDLDSIIDAVRTQYELIAQRSKDEAEALYQTKYQELQITAGRHGDDLKNSKMEIAELNRTVQRLQAEISNVKKQIEQMQSLISDAEERGEQALQDAWQKLQDLEEALQQSKEELARLLRDYQAMLGVKLSLDVEIATYRQLLEGEESRMSGELQSHVSISVQNSQVSVNGGAGGGGSYGSGGYGGGSGGGYGGGRSYRGGGARGRSGGGYGSGCGGGGGSYGGSGRSGRGSSRVQIIQTSTNTSHRRILE

3D Structural Models

Domain & Motif Annotations

Compositional Bias

547..556; Gly residues; 562..571; Polar residues

Domain (FT)

164..477; IF rod

Region

1..163; Head; 164..200; Coil 1A; 201..219; Linker 1; 220..311; Coil 1B; 312..335; Linker 12; 336..474; Coil 2; 475..578; Tail; 547..578; Disordered

Protein Families

Intermediate filament family

Sequence Similarities

Belongs to the intermediate filament family.

Clinical Relevance

Antibody

HPA045934

Interaction Protein

ENSG00000171345

Interaction Count

Interaction Dataset

intact_biogrid