Protein detail

PXK

PX domain-containing protein kinase-like protein (Modulator of Na,K-ATPase) (MONaKA)

Entry name PXK	UniProt ID Q7Z7A4	EVMP confidence score 0.38
Supporting publications (n) 3	Transmembrane count	Protein classification EnzymesPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

PX domain-containing protein kinase-like protein (Modulator of Na,K-ATPase) (MONaKA)

Protein Class (2)

EnzymesPredicted intracellular proteins

Protein Function (3)

Enzymes
Kinases
Predicted intracellular proteins

Ensembl

ENSG00000168297

Entrez Gene Symbol

PXK

Gene Synonym (2)

FLJ20335Slob

Gene Description

PX domain containing serine/threonine kinase like

Chromosome

Position

58332880-58426127

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization3

Tissue SpecificbrainCell SpecificBrain inhibitory neurons

Function & Pathway5

Protein Function (3)

Enzymes
Kinases
Predicted intracellular proteins

Cellular Component (6)

Molecular Function (3)

Biological Process (3)

Mediation Categories

Fusion and delivery mediation

Relations & Evidence9

Ligand-Receptor Signaling (8)

8 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Western blottingFlow cytometryMORPH	7	33035814 28986585 27894104 30646616 38321535 32089743 33709510

Sequence, Structure & Domains11

Sequences

Length

578

Mass

64,950

Sequence

MAFMEKPPAGKVLLDDTVPLTAAIEASQSLQSHTEYIIRVQRGISVENSWQIVRRYSDFDLLNNSLQIAGLSLPLPPKKLIGNMDREFIAERQKGLQNYLNVITTNHILSNCELVKKFLDPNNYSANYTEIALQQVSMFFRSEPKWEVVEPLKDIGWRIRKKYFLMKIKNQPKERLVLSWADLGPDKYLSDKDFQCLIKLLPSCLHPYIYRVTFATANESSALLIRMFNEKGTLKDLIYKAKPKDPFLKKYCNPKKIQGLELQQIKTYGRQILEVLKFLHDKGFPYGHLHASNVMLDGDTCRLLDLENSLLGLPSFYRSYFSQFRKINTLESVDVHCFGHLLYEMTYGRPPDSVPVDSFPPAPSMAVVAVLESTLSCEACKNGMPTISRLLQMPLFSDVLLTTSEKPQFKIPTKLKEALRIAKECIEKRLIEEQKQIHQHRRLTRAQSHHGSEEERKKRKILARKKSKRSALENSEEHSAKYSNSNNSAGSGASSPLTSPSSPTPPSTSGISALPPPPPPPPPPAAPLPPASTEAPAQLSSQAVNGMSRGALLSSIQNFQKGTLRKAKTCDHSAPKIG

Alternative Products

Event=Alternative splicing; Named isoforms=7; Name=1; Synonyms=Long, v1; IsoId=Q7Z7A4-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q7Z7A4-2; Sequence=VSP_051912, VSP_051913; Name=3; Synonyms=v3; IsoId=Q7Z7A4-3; Sequence=VSP_051907; Name=4; IsoId=Q7Z7A4-4; Sequence=VSP_051911; Name=5; Synonyms=v4; IsoId=Q7Z7A4-5; Sequence=VSP_051908; Name=6; Synonyms=v2; IsoId=Q7Z7A4-6; Sequence=VSP_051910; Name=7; Synonyms=v5; IsoId=Q7Z7A4-7; Sequence=VSP_051909

Alternative Sequence

1..226; Missing (in isoform 3); 1..137; Missing (in isoform 5); 1..83; Missing (in isoform 7); 35..67; Missing (in isoform 6); 35..51; Missing (in isoform 4); 510..515; GISALP -> VEHAPF (in isoform 2); 516..578; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

437..448; Basic residues; 457..469; Basic residues; 483..513; Low complexity; 514..530; Pro residues; 568..578; Basic and acidic residues

Domain (CC)

The protein kinase domain is predicted to be catalytically inactive.

Domain (FT)

14..126; PX; 88..481; Protein kinase; 548..567; WH2

Region

437..548; Disordered; 559..578; Disordered

Protein Families

Protein kinase superfamily

Sequence Similarities

Belongs to the protein kinase superfamily.

Clinical Relevance1

Antibody

HPA024068

Supporting Publications3

PMID	Title	Abstract
32218180	Proteomic Analysis of Blood Exosomes from Healthy Females and Breast Cancer Patients Reveals an Association between Different Exosomal Bioactivity on Non-tumorigenic Epithelial Cell and Breast Cancer Cell Migration in Vitro.	No abstract available
34202855	Proteomic Profiling of Ectosomes Derived from Paired Urothelial Bladder Cancer and Normal Cells Reveals the Presence of Biologically-Relevant Molecules.	No abstract available
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available