Protein detail

PXK

PX domain-containing protein kinase-like protein (Modulator of Na,K-ATPase) (MONaKA)

Entry name
PXK
UniProt ID
EVMP score
0.38
Frequency
3
Transmembrane count
Protein classification
EnzymesPredicted intracellular proteins
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
PX domain-containing protein kinase-like protein (Modulator of Na,K-ATPase) (MONaKA)
Protein Class
EnzymesPredicted intracellular proteins
Protein Function
  • Enzymes
  • Kinases
  • Predicted intracellular proteins
Entrez Gene Symbol
Gene Synonym
FLJ20335Slob
Gene Description
PX domain containing serine/threonine kinase like
Chromosome
3
Position
58332880-58426127
Frequency
3
EVMP Score
0.38
Fluorescence & Localization
PXK fluorescence
Tissue SpecificbrainCell SpecificBrain inhibitory neurons
Function & Pathway
Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

8 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
receptorreceptorOmniPathNoYesNoNoNo
intracellularintracellularComPPINoNoNoNoNo
intracellularintracellularGO_IntercellNoNoNoNoNo
intracellularintracellularUniProt_locationNoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo
plasma_membraneplasma_membraneUniProt_locationNoNoNoNoNo
plasma_membraneplasma_membraneOmniPathNoNoNoNoNo
receptorreceptorscConnectNoYesNoNoNo

Regulatory Interaction Network

0 records.

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyWestern blottingFlow cytometryMORPH733035814289865852789410430646616383215353208974333709510
Sequence, Structure & Domains

Sequences

Length
578
Mass
64,950
Sequence
MAFMEKPPAGKVLLDDTVPLTAAIEASQSLQSHTEYIIRVQRGISVENSWQIVRRYSDFDLLNNSLQIAGLSLPLPPKKLIGNMDREFIAERQKGLQNYLNVITTNHILSNCELVKKFLDPNNYSANYTEIALQQVSMFFRSEPKWEVVEPLKDIGWRIRKKYFLMKIKNQPKERLVLSWADLGPDKYLSDKDFQCLIKLLPSCLHPYIYRVTFATANESSALLIRMFNEKGTLKDLIYKAKPKDPFLKKYCNPKKIQGLELQQIKTYGRQILEVLKFLHDKGFPYGHLHASNVMLDGDTCRLLDLENSLLGLPSFYRSYFSQFRKINTLESVDVHCFGHLLYEMTYGRPPDSVPVDSFPPAPSMAVVAVLESTLSCEACKNGMPTISRLLQMPLFSDVLLTTSEKPQFKIPTKLKEALRIAKECIEKRLIEEQKQIHQHRRLTRAQSHHGSEEERKKRKILARKKSKRSALENSEEHSAKYSNSNNSAGSGASSPLTSPSSPTPPSTSGISALPPPPPPPPPPAAPLPPASTEAPAQLSSQAVNGMSRGALLSSIQNFQKGTLRKAKTCDHSAPKIG
Alternative Products
Event=Alternative splicing; Named isoforms=7; Name=1; Synonyms=Long, v1; IsoId=Q7Z7A4-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q7Z7A4-2; Sequence=VSP_051912, VSP_051913; Name=3; Synonyms=v3; IsoId=Q7Z7A4-3; Sequence=VSP_051907; Name=4; IsoId=Q7Z7A4-4; Sequence=VSP_051911; Name=5; Synonyms=v4; IsoId=Q7Z7A4-5; Sequence=VSP_051908; Name=6; Synonyms=v2; IsoId=Q7Z7A4-6; Sequence=VSP_051910; Name=7; Synonyms=v5; IsoId=Q7Z7A4-7; Sequence=VSP_051909
Alternative Sequence
1..226; Missing (in isoform 3); 1..137; Missing (in isoform 5); 1..83; Missing (in isoform 7); 35..67; Missing (in isoform 6); 35..51; Missing (in isoform 4); 510..515; GISALP -> VEHAPF (in isoform 2); 516..578; Missing (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Compositional Bias
437..448; Basic residues; 457..469; Basic residues; 483..513; Low complexity; 514..530; Pro residues; 568..578; Basic and acidic residues
Domain (CC)
The protein kinase domain is predicted to be catalytically inactive.
Domain (FT)
14..126; PX; 88..481; Protein kinase; 548..567; WH2
Region
437..548; Disordered; 559..578; Disordered
Protein Families
Protein kinase superfamily
Sequence Similarities
Belongs to the protein kinase superfamily.
Clinical Relevance
Antibody