Protein detail

FLIP1

Filamin-A-interacting protein 1 (FILIP)

Entry name FLIP1	UniProt ID Q7Z7B0	EVMP confidence score 0.38
Supporting publications (n) 3	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Filamin-A-interacting protein 1 (FILIP)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000118407

Entrez Gene Symbol

FILIP1

Gene Synonym (2)

FILIPKIAA1275

Gene Description

Filamin A interacting protein 1

Chromosome

Position

75291859-75493800

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization3

Cell SpecificEsophageal apical cellsBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component (5)

Biological Process (3)

Reactome (3)

Mediation Categories

Receptor-signaling mediation

Relations & Evidence8

Ligand-Receptor Signaling (5)

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
FILIP1-RhoD complex	FILIP1 RHOD	O00212 Q7Z7B0	0:0	CORUM	CORUM:6722	23087206
	CCT2 CCT3 CCT4 CCT6A CCT7 FILIP1 HSPA1B IGBP1 PPP2CA PPP2CB PPP2R2B PPP2R2C PPP2R2D PPP4C TCP1	P0DMV9 P17987 P40227 P49368 P50991 P60510 P62714 P67775 P78318 P78371 Q00005 Q66LE6 Q7Z7B0 Q99832 Q9Y2T4	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9233

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
	Mass spectrometry	0

Sequence, Structure & Domains10

Sequences

Length

1,213

Mass

138,109

Sequence

MRSRNQGGESASDGHISCPKPSIIGNAGEKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQEVLNLTKELELSKRYSRALRPSVNGRRMVDVPVTSTGVQTDAVSGEAAEEETPAVFIRKSFQEENHIMSNLRQVGLKKPVERSSVLDRYPPAANELTMRKSWIPWMRKRENGPSITQEKGPRTNSSPGHPGEVVLSPKQGQPLHIRVTPDHENSTATLEITSPTSEEFFSSTTVIPTLGNQKPRITIIPSPNVMPQKQKSGDTTLGPERAMSPVTITTFSREKTPESGRGAFADRPTSPIQIMTVSTSAAPAEIAVSPESQEMPMGRTILKVTPEKQTVPTPVRKYNSNANIITTEDNKIHIHLGSQFKRSPGTSGEGVSPVITVRPVNVTAEKEVSTGTVLRSPRNHLSSRPGASKVTSTITITPVTTSSARGTQSVSGQDGSSQRPTPTRIPMSKGMKAGKPVVAAPGAGNLTKFEPRAETQSMKIELKKSAASSTTSLGGGKG

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=L-FILIP; IsoId=Q7Z7B0-1; Sequence=Displayed; Name=2; IsoId=Q7Z7B0-2; Sequence=VSP_018345; Name=3; Synonyms=S-FILIP; IsoId=Q7Z7B0-3; Sequence=VSP_018344

Alternative Sequence

1..248; Missing (in isoform 3); 1165..1213; GMKAGKPVVAAPGAGNLTKFEPRAETQSMKIELKKSAASSTTSLGGGKG -> ESIIIHQLRMNSR (in isoform 2)

Domain & Motif Annotations

Compositional Bias

61..70; Basic and acidic residues; 880..894; Polar residues; 960..970; Polar residues; 1125..1138; Low complexity; 1139..1156; Polar residues; 1168..1179; Low complexity

Coiled Coil

192..591; 624..781

Region

1..70; Disordered; 878..900; Disordered; 949..976; Disordered; 1103..1213; Disordered

Protein Families

FILIP1 family

Sequence Similarities

Belongs to the FILIP1 family.

Clinical Relevance2

Disease Involvement

Disease variant

Antibody

HPA053564

Supporting Publications3

PMID	Title	Abstract
26775013	Proteomic characterization of circulating extracellular vesicles identifies novel serum myeloma associated markers.	No abstract available
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No abstract available