Protein detail
VTCN1
V-set domain-containing T-cell activation inhibitor 1 (B7 homolog 4) (B7-H4) (B7h.5) (Immune costimulatory protein B7-H4) (Protein B7S1) (T-cell costimulatory molecule B7x)
Entry name VTCN1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification Predicted intracellular proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
V-set domain-containing T-cell activation inhibitor 1 (B7 homolog 4) (B7-H4) (B7h.5) (Immune costimulatory protein B7-H4) (Protein B7S1) (T-cell costimulatory molecule B7x)
Protein Class
Predicted intracellular proteinsPredicted membrane proteins
Protein Function
Predicted intracellular proteins
Transmembrane
260..280; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
B7-H4B7H4B7S1B7xFLJ22418
Gene Description
V-set domain containing T cell activation inhibitor 1
Chromosome
1
Position
117143587-117210960
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificparathyroid glandCell SpecificCardiomyocytes
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
23 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 39408670 |
Sequence, Structure & Domains
Sequences
Length
282
Mass
30,878
Sequence
MASLGQILFWSIISIIIILAGAIALIIGFGISGRHSITVTTVASAGNIGEDGILSCTFEPDIKLSDIVIQWLKEGVLGLVHEFKEGKDELSEQDEMFRGRTAVFADQVIVGNASLRLKNVQLTDAGTYKCYIITSKGKGNANLEYKTGAFSMPEVNVDYNASSETLRCEAPRWFPQPTVVWASQVDQGANFSEVSNTSFELNSENVTMKVVSVLYNVTINNTYSCMIENDIAKATGDIKVTESEIKRRSHLQLLNSKASLCVSSFFAISWALLPLSPYLMLK
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q7Z7D3-1; Sequence=Displayed; Name=2; IsoId=Q7Z7D3-2; Sequence=VSP_052841; Name=3; IsoId=Q7Z7D3-3; Sequence=VSP_052842, VSP_052843; Name=4; IsoId=Q7Z7D3-4; Sequence=VSP_045423
Alternative Sequence
1..95; Missing (in isoform 4); 33..148; Missing (in isoform 2); 33..87; GRHSITVTTVASAGNIGEDGILSCTFEPDIKLSDIVIQWLKEGVLGLVHEFKEGK -> EVSVWLSAMKGWCRSSKASLSIDLCFLNFRETLHHSHYCRLSWEHWGGWNPELHF (in isoform 3); 88..282; Missing (in isoform 3)
3D Structural Models
Turn
105..107
Helix
64..66; 95..97; 108..110; 122..124
Beta Strand
39..42; 44..47; 52..58; 68..73; 77..84; 101..103; 115..119; 126..134; 137..148
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Domain (FT)
35..146; Ig-like V-type 1; 153..241; Ig-like V-type 2
Protein Families
- Immunoglobulin superfamily
- BTN/MOG family
Sequence Similarities
Belongs to the immunoglobulin superfamily. BTN/MOG family.