Protein detail

PHLB2

Pleckstrin homology-like domain family B member 2 (Protein LL5-beta)

Protein symbol
PHLB2
UniProt ID
EVMP score
0.63
Frequency
6
Transmembrane count
Protein classification
Predicted intracellular proteinsPredicted membrane proteins
Basic Information
Protein Names
Pleckstrin homology-like domain family B member 2 (Protein LL5-beta)
Protein Class
Predicted intracellular proteinsPredicted membrane proteins
Protein Function
Predicted intracellular proteins
Entrez Gene Symbol
Gene Synonym
FLJ21791LL5bLL5beta
Gene Description
Pleckstrin homology like domain family B member 2
Chromosome
3
Position
111732497-111976517
Frequency
6
EVMP Score
0.63
Fluorescence & Localization
Tissue SpecificbrainCell SpecificBergmann gliaBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes
Function & Pathway
Relations & Evidence

Enzyme-Mediated Modification

1 record.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
PHLDB2CSNK2A2P19784S489phosphorylationKEAKEA:17570479

Ligand-Receptor Signaling

4 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularComPPINoNoNoNoNo
intracellularintracellularGO_IntercellNoNoNoNoNo
intracellularintracellularUniProt_locationNoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo

Regulatory Interaction Network

0 records.

Protein Complex Composition

2 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
CLASP2PHLDB2O75122Q86SQ01:1PDBPDB:8whk
ACTBACTR3CAPZA1CAPZBHNRNPLLMYO6PHLDB2P47756P52907P60709P61158Q86SQ0Q8WVV9Q9UM540:0:0:0:0:0:0hu.MAP

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyMass spectrometryWestern blottingMORPH23303581434817906
Sequence, Structure & Domains

Sequences

Length
1,253
Mass
142,158
Sequence
MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYLTLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSGYPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMWNGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRKYSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDNYLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYVGTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q86SQ0-1; Sequence=Displayed; Name=2; IsoId=Q86SQ0-2; Sequence=VSP_016745; Name=3; IsoId=Q86SQ0-3; Sequence=VSP_016744, VSP_016745
Alternative Sequence
1; M -> MEEEDTKREVPKEDGVGDVQHFDSSKIM (in isoform 3); 668..710; Missing (in isoform 2 and isoform 3)

3D Structural Models

3D Structure
X-ray crystallography (3)

Domain & Motif Annotations

Compositional Bias
1..12; Basic and acidic residues; 29..43; Polar residues; 74..96; Polar residues; 126..144; Basic and acidic residues
Coiled Coil
584..696; 722..807; 1032..1098
Domain (CC)
The PH domain mediates the binding to phosphoinositides.
Domain (FT)
1143..1246; PH
Region
1..43; Disordered; 60..159; Disordered; 187..212; Disordered; 265..286; Disordered; 525..567; Disordered
Clinical Relevance
Interaction Protein
ENSG00000108953ENSG00000164924ENSG00000166913ENSG00000170027ENSG00000187555
Interaction Count
5
Interaction Dataset
biogrid_opencellintact_biogrid