Protein detail
DHDDS
Dehydrodolichyl diphosphate synthase complex subunit DHDDS (EC 2.5.1.87) (Cis-isoprenyltransferase) (CIT) (Cis-IPTase) (Cis-prenyltransferase subunit hCIT) (Epididymis tissue protein Li 189m)
Protein symbol DHDDS | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Disease related genesEnzymesEssential proteinsHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Dehydrodolichyl diphosphate synthase complex subunit DHDDS (EC 2.5.1.87) (Cis-isoprenyltransferase) (CIT) (Cis-IPTase) (Cis-prenyltransferase subunit hCIT) (Epididymis tissue protein Li 189m)
Protein Class
Disease related genesEnzymesEssential proteinsHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteins
Protein Function
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of glycan/glycoprotein metabolism
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Disease related genes
- Human disease related genes:Nervous system diseases:Eye disease
Ensembl
Entrez Gene Symbol
Gene Synonym
DSFLJ13102hCITHDSRP59
Gene Description
Dehydrodolichyl diphosphate synthase subunit
Chromosome
1
Position
26432282-26471306
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificBasal keratinocytes
Function & Pathway
Protein Function
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of glycan/glycoprotein metabolism
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Disease related genes
- Human disease related genes:Nervous system diseases:Eye disease
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-446203 asparagine n linked glycosylation
- R-hsa-446193 biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein
- R-hsa-5609975 diseases associated with glycosylation precursor biosynthesis
- R-hsa-3781865 diseases of glycosylation
- R-hsa-5668914 diseases of metabolism
- R-hsa-597592 post translational protein modification
- R-hsa-446199 synthesis of dolichyl phosphate
- R-hsa-446219 synthesis of substrates in n glycan biosythesis
Mediation Categories
Clinical-translation mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| DHDDS-NUS1 complex | DHDDSNUS1 | Q86SQ9Q96E22 | 2:2 | KEGG-MEDICUSCORUMComplexPortalhu.MAP2PDB | PDB:7paxPDB:7payPDB:6z1nPDB:6w2lPDB:6Z1NPDB:7pb0CORUM:6238intact:EBI-26971796PDB:7pb1 | 2506605621572394330777231475529232817466 |
| ABHD2AGPAT2ALYREFDHDDSLIPALSSSLC27A3UBC | O15120P08910P0CG48P38571P48449Q5K4L6Q86SQ9Q86V81 | 1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC8811 | ||
| ABHD2AGPAT2ALYREFDHDDSLIPALSSSLC27A4UBC | O15120P08910P0CG48P38571P48449Q6P1M0Q86SQ9Q86V81 | 1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC5118 | ||
| ABHD2AGPAT2ALYREFDHDDSLIPALSSSLC27A6UBC | O15120P08910P0CG48P38571P48449Q86SQ9Q86V81Q9Y2P4 | 1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC9623 | ||
| DHDDSFOXP4NUS1 | Q86SQ9Q8IVH2Q96E22 | 0:0:0 | hu.MAP |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometryR Sequencing | 0 |
Sequence, Structure & Domains
Sequences
Length
333
Mass
38,657
Sequence
MSWIKEGELSLWERFCANIIKAGPMPKHIAFIMDGNRRYAKKCQVERQEGHSQGFNKLAETLRWCLNLGILEVTVYAFSIENFKRSKSEVDGLMDLARQKFSRLMEEKEKLQKHGVCIRVLGDLHLLPLDLQELIAQAVQATKNYNKCFLNVCFAYTSRHEISNAVREMAWGVEQGLLDPSDISESLLDKCLYTNRSPHPDILIRTSGEVRLSDFLLWQTSHSCLVFQPVLWPEYTFWNLFEAILQFQMNHSVLQKARDMYAEERKRQQLERDQATVTEQLLREGLQASGDAQLRRTRLHKLSARREERVQGFLQALELKRADWLARLGTASA
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q86SQ9-1; Sequence=Displayed; Name=2; IsoId=Q86SQ9-2; Sequence=VSP_010031; Name=3; IsoId=Q86SQ9-3; Sequence=VSP_010030; Name=4; IsoId=Q86SQ9-4; Sequence=VSP_045007
Alternative Sequence
109..147; Missing (in isoform 3); 147..181; KCFLNVCFAYTSRHEISNAVREMAWGVEQGLLDPS -> N (in isoform 4); 255; Q -> QQ (in isoform 2)
3D Structural Models
Turn
2..4; 107..109; 193..196; 217..222
Helix
11..20; 36..42; 47..67; 80..84; 87..106; 110..113; 124..126; 129..142; 158..174; 180..182; 185..189; 232..234; 237..282; 283..285; 294..322; 325..327
Beta Strand
27..32; 72..79; 116..122; 147..156; 201..206; 214..216; 223..228
3D Structure
X-ray crystallography (6)
Domain & Motif Annotations
Domain (CC)
The catalytic site at NUS1-DHDDS interface accomodates both the allylic and the homoallylic IPP substrates to the S1 and S2 pockets respectively. The beta-phosphate groups of IPP substrates form hydrogen bonds with the RXG motif of NUS1 and four conserved residues of DHDDS (Arg-85, Arg-205, Arg-211 and Ser-213), while the allylic isopentenyl group is pointed toward the hydrophobic tunnel of the S1 pocket where the product elongation occurs.
Protein Families
UPP synthase family
Sequence Similarities
Belongs to the UPP synthase family.