Protein detail
KAISO
Transcriptional regulator Kaiso (Zinc finger and BTB domain-containing protein 33)
Entry name KAISO | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 2 | Transmembrane count | Protein classification Predicted intracellular proteinsTranscription factors |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Transcriptional regulator Kaiso (Zinc finger and BTB domain-containing protein 33)
Protein Class (2)
Predicted intracellular proteinsTranscription factors
Protein Function (2)
- Predicted intracellular proteins
- Transcription factors:Zinc-coordinating DNA-binding domains
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
kaisoWUGSC:H_DJ525N14.1ZNF-kaisoZNF348
Gene Description
Zinc finger and BTB domain containing 33
Chromosome
X
Position
120250752-120258398
Supporting publications (n)
2
EVMP confidence score
0.38
Fluorescence & Localization4
Tissue Specificsalivary glandCell SpecificBreast secretory cellsSingle-Nuclei Brain SpecificoligodendrocyteBlood Cell Specificplasmacytoid DC
Function & Pathway6
Protein Function (2)
- Predicted intracellular proteins
- Transcription factors:Zinc-coordinating DNA-binding domains
Cellular Component (6)
Molecular Function (8)
- GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
- GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
- GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
- GO:0005515 protein binding
- GO:0008327 methyl-CpG binding
- GO:0043565 sequence-specific DNA binding
- GO:0046872 metal ion binding
- GO:1990837 sequence-specific double-stranded DNA binding
Biological Process (3)
Reactome (5)
Mediation Categories
Receptor-signaling mediation
Relations & Evidence5
Ligand-Receptor Signaling (4)
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography | Mass spectrometry | 16 | 23161513322848253561146230379855377869183816890634817906289865852789410429045505306466163095018534571828399480404008906734186243 |
Sequence, Structure & Domains12
Sequences
Length
672
Mass
74,484
Sequence
MESRKLISATDIQYSGSLLNSLNEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQLFSVAGQVVELSFIRAEIFAEILNYIYSSKIVRVRSDLLDELIKSGQLLGVKFIAELGVPLSQVKSISGTAQDGNTEPLPPDSGDKNLVIQKSKDEAQDNGATIMPIITESFSLSAEDYEMKKIIVTDSDDDDDDVIFCSEILPTKETLPSNNTVAQVQSNPGPVAISDVAPSASNNSPPLTNITPTQKLPTPVNQATLSQTQGSEKLLVSSAPTHLTPNIILLNQTPLSTPPNVSSSLPNHMPSSINLLVQNQQTPNSAILTGNKANEEEEEEIIDDDDDTISSSPDSAVSNTSLVPQADTSQNTSFDGSLIQKMQIPTLLQEPLSNSLKISDIITRNTNDPGVGSKHLMEGQKIITLDTATEIEGLSTGCKVYANIGEDTYDIVIPVKDDPDEGEARLENEIPKTSGSEMANKRMKVKHDDHYELIVDGRVYYICIVCKRSYVCLTSLRRHFNIHSWEKKYPCRYCEKVFPLAEYRTKHEIHHTGERRYQCLACGKSFINYQFMSSHIKSVHSQDPSGDSKLYRLHPCRSLQIRQYAYLSDRSSTIPAMKDDGIGYKVDTGKEPPVGTTTSTQNKPMTWEDIFIQQENDSIFKQNVTDGSTEFEFIIPESY
3D Structural Models
Turn
28..31; 61..63; 497..499; 553..555
Helix
14..27; 47..53; 55..60; 75..85; 95..97; 98..108; 111..114; 506..517; 534..545; 562..572; 598..600
Beta Strand
34..38; 41..45; 66..70; 483..488; 491..496; 502..505; 525..528; 530..533; 550..552; 558..561; 579..581; 584..586
3D Structure
NMR spectroscopy (1); X-ray crystallography (18)
Domain & Motif Annotations
Compositional Bias
328..341; Acidic residues
Motif
471..480; Nuclear localization signal
Zinc Finger
494..516; C2H2-type 1; 522..544; C2H2-type 2; 550..573; C2H2-type 3
Domain (FT)
32..94; BTB
Region
1..136; Self-association; 1..103; Interaction with NCOR1; 298..573; Interaction with CBFA2T3; 325..354; Disordered; 454..672; Interaction with CTNND1; 514..638; Required for DNA-binding; 616..635; Disordered
Clinical Relevance4
Supporting Publications2
| PMID | Title | Abstract |
|---|---|---|
| 37922300 | Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women. | No abstract available |
| 40098346 | Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays. | No abstract available |