Protein detail

RSPH3

Radial spoke head protein 3 homolog (A-kinase anchor protein RSPH3) (Radial spoke head-like protein 2)

Entry name RSPH3	UniProt ID Q86UC2	EVMP score 0.38
Frequency 2	Transmembrane count	Protein classification Human disease related genesPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Radial spoke head protein 3 homolog (A-kinase anchor protein RSPH3) (Radial spoke head-like protein 2)

Protein Class

Human disease related genesPredicted intracellular proteins

Protein Function

Human disease related genes:Respiratory diseases:Tracheobronchial diseases
Predicted intracellular proteins

Ensembl

ENSG00000130363

Entrez Gene Symbol

RSPH3

Gene Synonym

dJ111C20.1RSHL2RSP3

Gene Description

Radial spoke head 3

Chromosome

Position

158972871-159000202

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue Specificlymphoid tissueCell SpecificB-cells

Function & Pathway

Protein Function

Human disease related genes:Respiratory diseases:Tracheobronchial diseases
Predicted intracellular proteins

Cellular Component

Molecular Function

GO:0005515 protein binding

Biological Process

Mediation Categories

Other mediation

Relations & Evidence

Enzyme-Mediated Modification

3 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
RSPH3	MAPK1	P28482	T	286	phosphorylation	SIGNOR	SIGNOR:19684019
RSPH3	MAPK1	P28482	T	243	phosphorylation	SIGNOR	SIGNOR:19684019
RSPH3	MAPK3	P27361	T	286	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper

Ligand-Receptor Signaling

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
MK01	P28482	RSPH3	Q86UC2	Yes	Yes	No	SIGNOR_ProtMapperiPTMnetSIGNORProtMapper	SIGNOR:19684019 ProtMapper:19684019
MK03	P27361	RSPH3	Q86UC2	Yes	No	No	iPTMnetPhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:19684019

Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	ATXN7L3 ENY2 KAT2A RSPH3 UBC USP22	P0CG48 Q14CW9 Q86UC2 Q92830 Q9NPA8 Q9UPT9	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5499
	ROPN1L RSPH14 RSPH3	Q86UC2 Q96C74 Q9UHP6	0:0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	38716512

Sequence, Structure & Domains

Sequences

Length

560

Mass

63,687

Sequence

MTVKPAKAASLARNLAKRRRTYLGGAAGRSQEPEVPCAAVLPGKPGDRNCPEFPPPDRTLGCWATDAAPAAGLCGAGSEPSIAPTSCAGNLPSRPPPLLSPLLASRNPCPWHYLHLSGSHNTLAPTCFKAKLHRKRGSQPPDMASALTDRTSRAPSTYTYTSRPRALPCQRSRYRDSLTQPDEEPMHYGNIMYDRRVIRGNTYALQTGPLLGRPDSLELQRQREARKRALARKQAQEQLRPQTPEPVEGRKHVDVQTELYLEEIADRIIEVDMECQTDAFLDRPPTPLFIPAKTGKDVATQILEGELFDFDLEVKPVLEVLVGKTIEQSLLEVMEEEELANLRASQREYEELRNSERAEVQRLEEQERRHREEKERRKKQQWEIMHKHNETSQKIAARAFAQRYLADLLPSVFGSLRDSGYFYDPIERDIEIGFLPWLMNEVEKTMEYSMVGRTVLDMLIREVVEKRLCMYEHGEDTHQSPEPEDEPGGPGAMTESLEASEFLEQSMSQTRELLLDGGYLQRTTYDRRSSQERKFMEERELLGQDEETAMRKSLGEEELS

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q86UC2-1; Sequence=Displayed; Name=2; IsoId=Q86UC2-2; Sequence=VSP_030128

Alternative Sequence

212..307; Missing (in isoform 2)

3D Structural Models

3D Structure

Electron microscopy (1)

Domain & Motif Annotations

Compositional Bias

153..162; Polar residues

Coiled Coil

215..239; 331..385

Region

134..186; Disordered; 225..249; Disordered; 354..375; Disordered; 473..498; Disordered; 526..560; Disordered

Protein Families

Flagellar radial spoke RSP3 family

Sequence Similarities

Belongs to the flagellar radial spoke RSP3 family.

Clinical Relevance

Antibody

HPA039109