Protein detail

TSN33

Tetraspanin-33 (Tspan-33) (Penumbra) (hPen) (Proerythroblast new membrane)

Protein symbol TSN33	UniProt ID Q86UF1	EVMP score 0.25
Frequency 1	Transmembrane count 4	Protein classification Predicted membrane proteinsTransporters

Basic Information

Protein Names

Tetraspanin-33 (Tspan-33) (Penumbra) (hPen) (Proerythroblast new membrane)

Protein Class

Predicted membrane proteinsTransporters

Protein Function

Transporters:Accessory Factors Involved in Transport

Transmembrane

25..45; Helical; 65..85; Helical; 97..117; Helical; 236..256; Helical

Transmembrane Count

Ensembl

ENSG00000158457

Entrez Gene Symbol

TSPAN33

Gene Synonym

MGC50844Penumbra

Gene Description

Tetraspanin 33

Chromosome

Position

129144707-129169699

Frequency

EVMP Score

0.25

Fluorescence & Localization

Function & Pathway

Protein Function

Transporters:Accessory Factors Involved in Transport

Cellular Component

Molecular Function

Biological Process

Reactome

R-hsa-977225 amyloid fiber formation

Mediation Categories

Fusion and delivery mediationMetabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

18 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	No	No
adhesion	adhesion	OmniPath	Yes	Yes	No	No	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No

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Regulatory Interaction Network

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PDZ11	Q5EBL8	TSN33	Q86UF1	Yes	Yes	No	SIGNOR	SIGNOR:30463011
TSN33	Q86UF1	ADA10	O14672	Yes	Yes	No	SIGNORIntAct	IntAct:23091066 SIGNOR:30463011 IntAct:26686862
PKHA7	Q6IQ23	TSN33	Q86UF1	Yes	Yes	No	SIGNOR	SIGNOR:30463011

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	PLEKHA7 TSPAN33	Q6IQ23 Q86UF1	0:0	hu.MAPhu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	3	33169421 28240915 33017416

Sequence, Structure & Domains

Sequences

Length

283

Mass

31,538

Sequence

MARRPRAPAASGEEFSFVSPLVKYLLFFFNMLFWVISMVMVAVGVYARLMKHAEAALACLAVDPAILLIVVGVLMFLLTFCGCIGSLRENICLLQTFSLCLTAVFLLQLAAGILGFVFSDKARGKVSEIINNAIVHYRDDLDLQNLIDFGQKKFSCCGGISYKDWSQNMYFNCSEDNPSRERCSVPYSCCLPTPDQAVINTMCGQGMQAFDYLEASKVIYTNGCIDKLVNWIHSNLFLLGGVALGLAIPQLVGILLSQILVNQIKDQIKLQLYNQQHRADPWY

3D Structural Models

Domain & Motif Annotations

Protein Families

Tetraspanin (TM4SF) family

Sequence Similarities

Belongs to the tetraspanin (TM4SF) family.

Clinical Relevance

Antibody

HPA020357