Protein detail

TSN33

Tetraspanin-33 (Tspan-33) (Penumbra) (hPen) (Proerythroblast new membrane)

Entry name TSN33	UniProt ID Q86UF1	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 4	Protein classification Predicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Tetraspanin-33 (Tspan-33) (Penumbra) (hPen) (Proerythroblast new membrane)

Protein Class (2)

Predicted membrane proteinsTransporters

Protein Function

Transporters:Accessory Factors Involved in Transport

Transmembrane

25..45; Helical; 65..85; Helical; 97..117; Helical; 236..256; Helical

Transmembrane Count

Ensembl

ENSG00000158457

Entrez Gene Symbol

TSPAN33

Gene Synonym (2)

MGC50844Penumbra

Gene Description

Tetraspanin 33

Chromosome

Position

129144707-129169699

Supporting publications (n)

EVMP confidence score

0.25

Function & Pathway6

Protein Function

Transporters:Accessory Factors Involved in Transport

Cellular Component (6)

Molecular Function (2)

Biological Process (3)

Reactome

R-hsa-977225 amyloid fiber formation

Mediation Categories (2)

Fusion and delivery mediationMetabolism mediation

Relations & Evidence23

Ligand-Receptor Signaling (18)

18 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	No	No
adhesion	adhesion	OmniPath	Yes	Yes	No	No	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No

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Regulatory Interaction Network (3)

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PDZ11	Q5EBL8	TSN33	Q86UF1	Yes	Yes	No	SIGNOR	SIGNOR:30463011
TSN33	Q86UF1	ADA10	O14672	Yes	Yes	No	SIGNORIntAct	IntAct:23091066 SIGNOR:30463011 IntAct:26686862
PKHA7	Q6IQ23	TSN33	Q86UF1	Yes	Yes	No	SIGNOR	SIGNOR:30463011

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	PLEKHA7 TSPAN33	Q6IQ23 Q86UF1	0:0	hu.MAPhu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	3	33169421 28240915 33017416

Sequence, Structure & Domains5

Sequences

Length

283

Mass

31,538

Sequence

MARRPRAPAASGEEFSFVSPLVKYLLFFFNMLFWVISMVMVAVGVYARLMKHAEAALACLAVDPAILLIVVGVLMFLLTFCGCIGSLRENICLLQTFSLCLTAVFLLQLAAGILGFVFSDKARGKVSEIINNAIVHYRDDLDLQNLIDFGQKKFSCCGGISYKDWSQNMYFNCSEDNPSRERCSVPYSCCLPTPDQAVINTMCGQGMQAFDYLEASKVIYTNGCIDKLVNWIHSNLFLLGGVALGLAIPQLVGILLSQILVNQIKDQIKLQLYNQQHRADPWY

Domain & Motif Annotations

Protein Families

Tetraspanin (TM4SF) family

Sequence Similarities

Belongs to the tetraspanin (TM4SF) family.

Clinical Relevance1

Antibody

HPA020357

Supporting Publications1

PMID	Title	Abstract
38590132	Proteomic Identification of Small Extracellular Vesicle Proteins LAMB1 and Histone H4 for Prostate Cancer Diagnosis and Risk Stratification.	No abstract available