Protein detail

ZN598

E3 ubiquitin-protein ligase ZNF598 (EC 2.3.2.27) (Zinc finger protein 598)

Entry name ZN598	UniProt ID Q86UK7	EVMP confidence score 0.38
Supporting publications (n) 2	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

E3 ubiquitin-protein ligase ZNF598 (EC 2.3.2.27) (Zinc finger protein 598)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000167962

Entrez Gene Symbol

ZNF598

Gene Synonym (2)

FLJ00086HEL2

Gene Description

Zinc finger protein 598, E3 ubiquitin ligase

Chromosome

Position

1997654-2009821

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization2

Tissue SpecifickidneyCell SpecificProximal tubule cells

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component (2)

Molecular Function (7)

Reactome (2)

Mediation Categories

Other mediation

Relations & Evidence151

Enzyme-Mediated Modification (1)

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
ZNF598	EGF	P01133	Y	289	phosphorylation	BEL-Large-Corpus_ProtMapperProtMapper	ProtMapper:17081983

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network (136)

136 records.

Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
COMPLEX:P0CG48_Q9NPD8	ZN598	Q86UK7	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P0CG47_P51965	ZN598	Q86UK7	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P61081_P62987	ZN598	Q86UK7	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P0CG47_P51668	ZN598	Q86UK7	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P0CG48_P62837	ZN598	Q86UK7	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P0CG47_P68036	ZN598	Q86UK7	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P62979_Q8N2K1	ZN598	Q86UK7	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P0CG48_P61088	ZN598	Q86UK7	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P62987_Q9Y2X8	ZN598	Q86UK7	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P0CG48_P60604	ZN598	Q86UK7	Yes	Yes	No	SIGNOR	SIGNOR:34199813

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Protein Complex Composition (9)

9 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
4EHP-GIGYF1 co-translational mRNA decay complexZNF598 variant	EIF4E2 GIGYF1 ZNF598	O60573 O75420 Q86UK7	1:1:1	ComplexPortal	PDB:5nvk	14755292 33053355 28698298
4EHP-GIGYF2 co-translational mRNA decay complexZNF598 variant	EIF4E2 GIGYF2 ZNF598	O60573 Q6Y7W6 Q86UK7	1:1:1	ComplexPortal		14755292 33053355 28698298
Ub:RING_E3	UBB ZNF598	P0CG47 Q86UK7	0:0	SIGNOR	SIGNOR:SIGNOR-C519
Ub:RING_E3	UBC ZNF598	P0CG48 Q86UK7	0:0	SIGNOR	SIGNOR:SIGNOR-C519
Ub:RING_E3	RPS27A ZNF598	P62979 Q86UK7	0:0	SIGNOR	SIGNOR:SIGNOR-C519
Ub:RING_E3	UBA52 ZNF598	P62987 Q86UK7	0:0	SIGNOR	SIGNOR:SIGNOR-C519
	GTF2F1 GTF2F2 IWS1 POLR2A POLR2B POLR2C POLR2E POLR2G POLR2H POLR2J SUPT5H SUPT6H TCEA1 UBC ZNF598	O00267 P0CG48 P13984 P19387 P19388 P23193 P24928 P30876 P35269 P52434 P52435 P62487 Q7KZ85 Q86UK7 Q96ST2	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7916
	CUTC EDF1 ERCC4 GALNT4 POC1B XPA ZNF598	O60869 P23025 Q86UK7 Q8N4A0 Q8TC44 Q92889 Q9NTM9	0:0:0:0:0:0:0	hu.MAP2
	GALNT4 POC1B ZNF598	Q86UK7 Q8N4A0 Q8TC44	0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	4	33169421 31414377 28240915 32331267

Sequence, Structure & Domains10

Sequences

Length

904

Mass

98,637

Sequence

MAAAGGAEGRRAALEAAAAAAPERGGGSCVLCCGDLEATALGRCDHPVCYRCSTKMRVLCEQRYCAVCREELRQVVFGKKLPAFATIPIHQLQHEKKYDIYFADGKVYALYRQLLQHECPRCPELPPFSLFGDLEQHMRRQHELFCCRLCLQHLQIFTYERKWYSRKDLARHRMQGDPDDTSHRGHPLCKFCDERYLDNDELLKHLRRDHYFCHFCDSDGAQDYYSDYAYLREHFREKHFLCEEGRCSTEQFTHAFRTEIDLKAHRTACHSRSRAEARQNRHIDLQFSYAPRHSRRNEGVVGGEDYEEVDRYSRQGRVARAGTRGAQQSRRGSWRYKREEEDREVAAAVRASVAAQQQEEARRSEDQEEGGRPKKEEAAARGPEDPRGPRRSPRTQGEGPGPKETSTNGPVSQEAFSVTGPAAPGCVGVPGALPPPSPKLKDEDFPSLSASTSSSCSTAATPGPVGLALPYAIPARGRSAFQEEDFPALVSSVPKPGTAPTSLVSAWNSSSSSKKVAQPPLSAQATGSGQPTRKAGKGSRGGRKGGPPFTQEEEEDGGPALQELLSTRPTGSVSSTLGLASIQPSKVGKKKKVGSEKPGTTLPQPPPATCPPGALQAPEAPASRAEGPVAVVVNGHTEGPAPARSAPKEPPGLPRPLGSFPCPTPQEDFPALGGPCPPRMPPPPGFSAVVLLKGTPPPPPPGLVPPISKPPPGFSGLLPSPHPACVPSPATTTTTKAPRLLPAPRAYLVPENFRERNLQLIQSIRDFLQSDEARFSEFKSHSGEFRQGLISAAQYYKSCRDLLGENFQKVFNELLVLLPDTAKQQELLSAHTDFCNREKPLSTKSKKNKKSAWQATTQQAGLDCRVCPTCQQVLAHGDASSHQALHAARDDDFPSLQAIARIIT

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q86UK7-1; Sequence=Displayed; Name=2; IsoId=Q86UK7-2; Sequence=VSP_020661, VSP_020663, VSP_020664; Name=3; IsoId=Q86UK7-3; Sequence=VSP_020663; Name=4; IsoId=Q86UK7-4; Sequence=VSP_020660, VSP_020662, VSP_020664, VSP_020665

Alternative Sequence

1..397; Missing (in isoform 4); 335..337; Missing (in isoform 2); 398..431; EGPGPKETSTNGPVSQEAFSVTGPAAPGCVGVPG -> MVGGCGQPQVGAGRAGMEPRGLIAVDQLCFPAPS (in isoform 4); 424..429; Missing (in isoform 2 and isoform 3); 551; Q -> QE (in isoform 2 and isoform 4); 738..904; Missing (in isoform 4)

Domain & Motif Annotations

Compositional Bias

346..358; Low complexity; 359..388; Basic and acidic residues; 404..416; Polar residues; 418..431; Low complexity; 447..461; Low complexity; 502..513; Low complexity; 521..531; Polar residues; 534..543; Basic residues; 564..584; Polar residues

Zinc Finger

29..69; RING-type; 187..210; C2H2-type

Region

312..469; Disordered; 490..656; Disordered

Protein Families

ZNF598/HEL2 family

Sequence Similarities

Belongs to the ZNF598/HEL2 family.

Clinical Relevance4

Antibody (2)

HPA041760 HPA041896

Interaction Protein (4)

ENSG00000105193ENSG00000106263ENSG00000108953ENSG00000204628

Interaction Count

Interaction Dataset

biogrid_opencell

Supporting Publications2

PMID	Title	Abstract
37922300	Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women.	No abstract available
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available