Protein detail
R4RL1
Reticulon-4 receptor-like 1 (Nogo receptor-like 2) (Nogo-66 receptor homolog 2) (Nogo-66 receptor-related protein 3) (NgR3)
Protein symbol R4RL1 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Reticulon-4 receptor-like 1 (Nogo receptor-like 2) (Nogo-66 receptor homolog 2) (Nogo-66 receptor-related protein 3) (NgR3)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
DKFZp547J144NgR3NGRH2
Gene Description
Reticulon 4 receptor like 1
Chromosome
17
Position
1934677-2025334
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificblood vesselCell SpecificExtravillous trophoblastsSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificT-regBlood Lineage SpecificT-cellsSecretome LocationSecreted to extracellular matrixSecretome FunctionNo annotated function
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
28 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | GO_Intercell | No | Yes | No | No | No |
| receptor | receptor | CellTalkDB | No | Yes | No | No | No |
| receptor | receptor | Ramilowski2015 | No | Yes | No | No | No |
| receptor | receptor | LRdb | No | Yes | No | No | No |
| receptor | receptor | Baccin2019 | No | Yes | No | No | No |
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
441
Mass
49,065
Sequence
MLRKGCCVELLLLLVAAELPLGGGCPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRIGLLQPGHFSPAMVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGNPWDCGCRARSLWEWLQRFRGSSSAVPCVSPGLRHGQDLKLLRAEDFRNCTGPASPHQIKSHTLTTTDRAARKEHHSPHGPTRSKGHPHGPRPGHRKPGKNCTNPRNRNQISKAGAGKQAPELPDYAPDYQHKFSFDIMPTARPKRKGKCARRTPIRAPSGVQQASSASSLGASLLAWTLGLAVTLR
3D Structural Models
Domain & Motif Annotations
Compositional Bias
326..353; Basic residues; 355..366; Polar residues; 397..409; Basic residues
Repeat
55..76; LRR 1; 77..98; LRR 2; 101..123; LRR 3; 126..147; LRR 4; 150..171; LRR 5; 174..195; LRR 6; 198..219; LRR 7; 222..243; LRR 8
Domain (FT)
25..54; LRRNT; 255..306; LRRCT
Region
304..382; Disordered; 397..417; Disordered
Protein Families
Nogo receptor family
Sequence Similarities
Belongs to the Nogo receptor family.
Clinical Relevance
Antibody