Protein detail
C163A
Scavenger receptor cysteine-rich type 1 protein M130 (Hemoglobin scavenger receptor) (CD antigen CD163) [Cleaved into: Soluble CD163 (sCD163)]
Entry name C163A | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 4 | Transmembrane count 1 | Protein classification CD markersPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Scavenger receptor cysteine-rich type 1 protein M130 (Hemoglobin scavenger receptor) (CD antigen CD163) [Cleaved into: Soluble CD163 (sCD163)]
Protein Class (5)
CD markersPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteins
Protein Function (3)
- Predicted secreted proteins
- CD markers
- Predicted intracellular proteins
Transmembrane
1051..1071; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
M130MM130SCARI1
Gene Description
CD163 molecule
Chromosome
12
Position
7470811-7503893
Supporting publications (n)
4
EVMP confidence score
0.50
Fluorescence & Localization2
Cell SpecificmonocytesSingle-Nuclei Brain Specificendothelial cell
Function & Pathway6
Protein Function (3)
- Predicted secreted proteins
- CD markers
- Predicted intracellular proteins
Cellular Component (5)
Molecular Function (3)
Biological Process (3)
Reactome (7)
- R-hsa-9662851 anti inflammatory response favouring leishmania parasite infection
- R-hsa-2173782 binding and uptake of ligands by scavenger receptors
- R-hsa-9662834 cd163 mediating an anti inflammatory response
- R-hsa-5663205 infectious disease
- R-hsa-9658195 leishmania infection
- R-hsa-2168880 scavenging of heme from plasma
- R-hsa-5653656 vesicle mediated transport
Mediation Categories (2)
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence49
Enzyme-Mediated Modification (3)
3 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| CD163 | PRKCA | P17252 | S | 1,084 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapper | HPRD:11298324SIGNOR:11298324KEA:11298324ProtMapper:11298324HPRD:20166139 |
| CD163 | PRKCA | P17252 | T | 1,072 | phosphorylation | MIMPHPRD_MIMPKEA | KEA:11298324 |
| CD163 | CSNK2B | P67870 | S | 1,085 | phosphorylation | MIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapper | SIGNOR:11298324ProtMapper:11298324KEA:11298324 |
Ligand-Receptor Signaling (37)
37 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | OmniPath | No | No | Yes | Yes | No |
| scavenger_receptor_cysteine_rich | secreted_receptor | OmniPath | Yes | No | Yes | Yes | No |
| scavenger | secreted_receptor | OmniPath | Yes | No | Yes | Yes | No |
| secreted_receptor | secreted_receptor | OmniPath | Yes | No | Yes | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | Yes | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | Yes | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | Yes | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | Yes | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | Yes | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | Yes | Yes | No |
Regulatory Interaction Network (5)
5 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| HBB | P68871 | C163A | Q86VB7 | Yes | Yes | No | SIGNOR | SIGNOR:16522161 |
| HBA | P69905 | C163A | Q86VB7 | Yes | Yes | No | SIGNOR | SIGNOR:16522161 |
| CSK2B | P67870 | C163A | Q86VB7 | Yes | Yes | No | MIMPHPRD_MIMPSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperLit-BM-17SPIKE_LC | Lit-BM-17:11298324SIGNOR:11298324HPRD:11298324KEA:11298324SPIKE_LC:16713569ProtMapper:11298324 |
| KPCA | P17252 | C163A | Q86VB7 | Yes | No | No | PhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperHPRD-phos | HPRD-phos:11298324HPRD:11298324SIGNOR:11298324ProtMapper:20166139KEA:11298324HPRD-phos:20166139ProtMapper:11298324 |
| C163A | Q86VB7 | COMPLEX:P00738_P68871_P69905 | Yes | No | Yes | SIGNOR | SIGNOR:11854029 |
Protein Complex Composition (3)
Isolation & Detection Technology (1)
1 record.
Sequence, Structure & Domains12
Sequences
Length
1,156
Mass
125,451
Sequence
MSKLRMVLLEDSGSADFRRHFVNLSPFTITVVLLLSACFVTSSLGGTDKELRLVDGENKCSGRVEVKVQEEWGTVCNNGWSMEAVSVICNQLGCPTAIKAPGWANSSAGSGRIWMDHVSCRGNESALWDCKHDGWGKHSNCTHQQDAGVTCSDGSNLEMRLTRGGNMCSGRIEIKFQGRWGTVCDDNFNIDHASVICRQLECGSAVSFSGSSNFGEGSGPIWFDDLICNGNESALWNCKHQGWGKHNCDHAEDAGVICSKGADLSLRLVDGVTECSGRLEVRFQGEWGTICDDGWDSYDAAVACKQLGCPTAVTAIGRVNASKGFGHIWLDSVSCQGHEPAIWQCKHHEWGKHYCNHNEDAGVTCSDGSDLELRLRGGGSRCAGTVEVEIQRLLGKVCDRGWGLKEADVVCRQLGCGSALKTSYQVYSKIQATNTWLFLSSCNGNETSLWDCKNWQWGGLTCDHYEEAKITCSAHREPRLVGGDIPCSGRVEVKHGDTWGSICDSDFSLEAASVLCRELQCGTVVSILGGAHFGEGNGQIWAEEFQCEGHESHLSLCPVAPRPEGTCSHSRDVGVVCSRYTEIRLVNGKTPCEGRVELKTLGAWGSLCNSHWDIEDAHVLCQQLKCGVALSTPGGARFGKGNGQIWRHMFHCTGTEQHMGDCPVTALGASLCPSEQVASVICSGNQSQTLSSCNSSSLGPTRPTIPEESAVACIESGQLRLVNGGGRCAGRVEIYHEGSWGTICDDSWDLSDAHVVCRQLGCGEAINATGSAHFGEGTGPIWLDEMKCNGKESRIWQCHSHGWGQQNCRHKEDAGVICSEFMSLRLTSEASREACAGRLEVFYNGAWGTVGKSSMSETTVGVVCRQLGCADKGKINPASLDKAMSIPMWVDNVQCPKGPDTLWQCPSSPWEKRLASPSEETWITCDNKIRLQEGPTSCSGRVEIWHGGSWGTVCDDSWDLDDAQVVCQQLGCGPALKAFKEAEFGQGTGPIWLNEVKCKGNESSLWDCPARRWGHSECGHKEDAAVNCTDISVQKTPQKATTGRSSRQSSFIAVGILGVVLLAIFVALFFLTKKRRQRQRLAVSSRGENLVHQIQYREMNSCLNADDLDLMNSSENSHESADFSAAELISVSKFLPISGMEKEAILSHTEKENGNL
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Long tail variant 1; IsoId=Q86VB7-1; Sequence=Displayed; Name=2; Synonyms=Long tail variant 2; IsoId=Q86VB7-2; Sequence=VSP_019014; Name=3; Synonyms=Short tail variant; IsoId=Q86VB7-3; Sequence=VSP_019015; Name=4; IsoId=Q86VB7-4; Sequence=VSP_019013, VSP_019015
Alternative Sequence
579; R -> SKTQKTSLIGSYTVKGTGLGSHSCLFLKPCLLPG (in isoform 4); 1115..1156; ENSHESADFSAAELISVSKFLPISGMEKEAILSHTEKENGNL -> GLWVLGGSIAQGFRSVAAVEAQTFYFDKQLKKSKNVIGSLDAYNGQE (in isoform 2); 1115..1156; ENSHESADFSAAELISVSKFLPISGMEKEAILSHTEKENGNL -> GGHSEPH (in isoform 3 and isoform 4)
3D Structural Models
Turn
259..261; 529..533; 917..919; 1005..1007
Helix
190..199; 250..252; 297..307; 357..359; 404..414; 449..451; 504..506; 509..518; 554..556; 569..571; 614..623; 659..661; 750..759; 795..797; 810..812; 857..866; 902..904; 960..970; 1020..1022
Beta Strand
159..176; 179..184; 204..209; 233..235; 241..244; 255..258; 266..273; 276..283; 286..289; 312..317; 326..328; 340..342; 362..366; 368..380; 383..392; 396..398; 419..422; 436..439; 452..460; 469..472; 476..482; 488..495; 498..503; 523..528; 538..541; 543..545; 559..561; 574..578; 583..587; 593..600; 603..605; 609..611; 629..631; 635..638; 656..658; 679..682; 719..726; 729..736; 739..742; 764..769; 783..785; 790..793; 815..818; 823..827; 836..843; 846..851; 873..876; 888..890; 922..925; 928..933; 939..946; 949..954; 975..977; 991..993; 1012..1014; 1025..1028
3D Structure
Electron microscopy (13)
Domain & Motif Annotations
Motif
1096..1099; Internalization signal
Domain (CC)
The SRCR domain 3 mediates calcium-sensitive interaction with hemoglobin/haptoglobin complexes.
Domain (FT)
51..152; SRCR 1; 159..259; SRCR 2; 266..366; SRCR 3; 373..473; SRCR 4; 478..578; SRCR 5; 583..683; SRCR 6; 719..819; SRCR 7; 824..926; SRCR 8; 929..1029; SRCR 9
Clinical Relevance2
Supporting Publications4
| PMID | Title | Abstract |
|---|---|---|
| 20031610 | Proteomics, metabolomics, and immunomics on microparticles derived from human atherosclerotic plaques. | No abstract available |
| 30950185 | Unique Protein Profiles of Extracellular Vesicles as Diagnostic Biomarkers for Early and Advanced Non-Small Cell Lung Cancer. | No abstract available |
| 33204424 | Proteomic analysis of extracellular vesicles reveals an immunogenic cargo in rheumatoid arthritis synovial fluid. | No abstract available |
| 40748658 | Exosomes released from senescent cells and circulatory exosomes isolated from human plasma reveal aging-associated proteomic and lipid signatures. | No abstract available |