Protein detail

SERC5

Serine incorporator 5

Entry name SERC5	UniProt ID Q86VE9	EVMP confidence score 0.40
Supporting publications (n) 1	Transmembrane count 9	Protein classification Predicted membrane proteinsTransporters

Basic Information

Protein Names

Serine incorporator 5

Protein Class (2)

Predicted membrane proteinsTransporters

Protein Function

Transporters

Transmembrane

37..57; Helical; 90..110; Helical; 125..145; Helical; 157..177; Helical; 199..219; Helical; 231..251; Helical; 259..279; Helical; 312..332; Helical; 386..406; Helical

Transmembrane Count

Ensembl

ENSG00000164300

Entrez Gene Symbol

SERINC5

Gene Synonym (2)

C5orf12TPO1

Gene Description

Serine incorporator 5

Chromosome

Position

80111651-80256048

Supporting publications (n)

EVMP confidence score

0.40

Fluorescence & Localization

Tissue Specificblood vesselCell SpecificAdipocytesSingle-Nuclei Brain SpecificastrocyteBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes

Function & Pathway

Protein Function

Transporters

Cellular Component (9)

Molecular Function

GO:0015194 L-serine transmembrane transporter activity

Biological Process (3)

KEGG

hsa03250 Viral life cycle - HIV-1

Reactome (2)

Mediation Categories (2)

Fusion and delivery mediationMetabolism mediation

Relations & Evidence19

Enzyme-Mediated Modification (1)

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
SERINC5	CDK13	Q14004	S	360	phosphorylation	PhosphoSite

Ligand-Receptor Signaling (16)

16 records.

Category	Parent	Database	Receiver
intracellular	intracellular	GO_Intercell
intracellular	intracellular	UniProt_location
intracellular	intracellular	OmniPath
transporter	transporter	Surfaceome	Yes
serinc	transporter	Surfaceome	Yes
transporter	transporter	OmniPath	Yes
transmembrane	transmembrane	UniProt_location
transmembrane	transmembrane	UniProt_topology
transmembrane	transmembrane	UniProt_keyword
transmembrane	transmembrane	Ramilowski_location

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
CDK13	Q14004	SERC5	Q86VE9	Yes		Yes	SIGNORPhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:34380030 SIGNOR:34380030

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration	Mass spectrometry	9	37862381 39949490 32795414 38731868 38490958 28369848 30760538 31320591 40091455

Sequence, Structure & Domains

Sequences

Length

423

Mass

47,009

Sequence

MSAQCCAGQLACCCGSAGCSLCCDCCPRIRQSLSTRFMYALYFILVVVLCCIMMSTTVAHKMKEHIPFFEDMCKGIKAGDTCEKLVGYSAVYRVCFGMACFFFIFCLLTLKINNSKSCRAHIHNGFWFFKLLLLGAMCSGAFFIPDQDTFLNAWRYVGAVGGFLFIGIQLLLLVEFAHKWNKNWTAGTASNKLWYASLALVTLIMYSIATGGLVLMAVFYTQKDSCMENKILLGVNGGLCLLISLVAISPWVQNRQPHSGLLQSGVISCYVTYLTFSALSSKPAEVVLDEHGKNVTICVPDFGQDLYRDENLVTILGTSLLIGCILYSCLTSTTRSSSDALQGRYAAPELEIARCCFCFSPGGEDTEEQQPGKEGPRVIYDEKKGTVYIYSYFHFVFFLASLYVMMTVTNWFNHVRSAFHLLP

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q86VE9-1; Sequence=Displayed; Name=2; IsoId=Q86VE9-2; Sequence=VSP_033055; Name=3; IsoId=Q86VE9-3; Sequence=VSP_033054; Name=4; IsoId=Q86VE9-4; Sequence=VSP_042310

Alternative Sequence

413..423; NHVRSAFHLLP -> KNYQC (in isoform 3); 413..416; NHVR -> K (in isoform 2); 414..423; HVRSAFHLLP -> YESANIESFFSGSWSIFWVKMASCWICVLLYLCTLVAPLCCPTREFSV (in isoform 4)

Domain & Motif Annotations

Protein Families

TDE1 family

Sequence Similarities

Belongs to the TDE1 family.

Clinical Relevance

Drugs

MEPERIDINE HYDROCHLORIDE

Antibody (2)

HPA037898 HPA037899

Supporting Publications1

PMID	Title	Related sentences
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No related sentences available