Protein detail

SERC5

Serine incorporator 5

Entry name SERC5	UniProt ID Q86VE9	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 9	Protein classification Predicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Serine incorporator 5

Protein Class (2)

Predicted membrane proteinsTransporters

Protein Function

Transporters

Transmembrane

37..57; Helical; 90..110; Helical; 125..145; Helical; 157..177; Helical; 199..219; Helical; 231..251; Helical; 259..279; Helical; 312..332; Helical; 386..406; Helical

Transmembrane Count

Ensembl

ENSG00000164300

Entrez Gene Symbol

SERINC5

Gene Synonym (2)

C5orf12TPO1

Gene Description

Serine incorporator 5

Chromosome

Position

80111651-80256048

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization5

Tissue Specificblood vesselCell SpecificAdipocytesSingle-Nuclei Brain SpecificastrocyteBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes

Function & Pathway7

Protein Function

Transporters

Cellular Component (9)

Molecular Function

GO:0015194 L-serine transmembrane transporter activity

Biological Process (3)

KEGG

hsa03250 Viral life cycle - HIV-1

Reactome (2)

Mediation Categories (2)

Fusion and delivery mediationMetabolism mediation

Relations & Evidence19

Enzyme-Mediated Modification (1)

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
SERINC5	CDK13	Q14004	S	360	phosphorylation	PhosphoSite

Ligand-Receptor Signaling (16)

16 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transporter	transporter	Surfaceome	No	Yes	No	No	No
serinc	transporter	Surfaceome	No	Yes	No	No	No
transporter	transporter	OmniPath	No	Yes	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
CDK13	Q14004	SERC5	Q86VE9	Yes	No	Yes	SIGNORPhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:34380030 SIGNOR:34380030

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration	Mass spectrometry	9	37862381 39949490 32795414 38731868 38490958 28369848 30760538 31320591 40091455

Sequence, Structure & Domains7

Sequences

Length

423

Mass

47,009

Sequence

MSAQCCAGQLACCCGSAGCSLCCDCCPRIRQSLSTRFMYALYFILVVVLCCIMMSTTVAHKMKEHIPFFEDMCKGIKAGDTCEKLVGYSAVYRVCFGMACFFFIFCLLTLKINNSKSCRAHIHNGFWFFKLLLLGAMCSGAFFIPDQDTFLNAWRYVGAVGGFLFIGIQLLLLVEFAHKWNKNWTAGTASNKLWYASLALVTLIMYSIATGGLVLMAVFYTQKDSCMENKILLGVNGGLCLLISLVAISPWVQNRQPHSGLLQSGVISCYVTYLTFSALSSKPAEVVLDEHGKNVTICVPDFGQDLYRDENLVTILGTSLLIGCILYSCLTSTTRSSSDALQGRYAAPELEIARCCFCFSPGGEDTEEQQPGKEGPRVIYDEKKGTVYIYSYFHFVFFLASLYVMMTVTNWFNHVRSAFHLLP

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q86VE9-1; Sequence=Displayed; Name=2; IsoId=Q86VE9-2; Sequence=VSP_033055; Name=3; IsoId=Q86VE9-3; Sequence=VSP_033054; Name=4; IsoId=Q86VE9-4; Sequence=VSP_042310

Alternative Sequence

413..423; NHVRSAFHLLP -> KNYQC (in isoform 3); 413..416; NHVR -> K (in isoform 2); 414..423; HVRSAFHLLP -> YESANIESFFSGSWSIFWVKMASCWICVLLYLCTLVAPLCCPTREFSV (in isoform 4)

Domain & Motif Annotations

Protein Families

TDE1 family

Sequence Similarities

Belongs to the TDE1 family.

Clinical Relevance2

Drugs

MEPERIDINE HYDROCHLORIDE

Antibody (2)

HPA037898 HPA037899

Supporting Publications1

PMID	Title	Abstract
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No abstract available