Protein detail
P2RY8
S-geranylgeranyl-glutathione receptor P2RY8 (P2Y purinoceptor 8) (P2Y8)
Protein symbol P2RY8 | UniProt ID | EVMP score 0.25 |
Frequency 4 | Transmembrane count 7 | Protein classification Cancer-related genesG-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
S-geranylgeranyl-glutathione receptor P2RY8 (P2Y purinoceptor 8) (P2Y8)
Protein Class
Cancer-related genesG-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- G-protein coupled receptors:Adenosine and adenine nucleotide receptors
- G-protein coupled receptors:GPCRs excl olfactory receptors
- Predicted intracellular proteins
- Cancer-related genes
Transmembrane
20..40; Helical; Name=1; 58..78; Helical; Name=2; 89..109; Helical; Name=3; 139..159; Helical; Name=4; 188..208; Helical; Name=5; 238..258; Helical; Name=6; 276..296; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
P2Y8
Gene Description
P2Y receptor family member 8
Chromosome
X
Position
1462581-1537185
Frequency
4
EVMP Score
0.25
Fluorescence & Localization
Tissue Specificblood vesselCell SpecificEpididymal efferent duct absorptive cellsSingle-Nuclei Brain SpecificfibroblastBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function
- G-protein coupled receptors:Adenosine and adenine nucleotide receptors
- G-protein coupled receptors:GPCRs excl olfactory receptors
- Predicted intracellular proteins
- Cancer-related genes
Cellular Component
Molecular Function
Biological Process
Canonical Pathways
M99 Pid txa2pathway
Mediation Categories
Receptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
43 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | HPMR | No | Yes | No | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | No | Yes | No |
| gpcr | receptor | DGIdb | No | Yes | No | Yes | No |
| pseudoautosomal_region | receptor | OmniPath | No | Yes | No | Yes | No |
| gpcr | receptor | Almen2009 | No | Yes | No | Yes | No |
| rhodopsin | receptor | Almen2009 | No | Yes | No | Yes | No |
| gpcr | receptor | UniProt_keyword | No | Yes | No | Yes | No |
| seven_transmembrane_7tm | receptor | HPMR | No | Yes | No | Yes | No |
| 7tm_a | receptor | HPMR | No | Yes | No | Yes | No |
| vasopressin_oxytocin_7tm_a | receptor | HPMR | No | Yes | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 37633233 |
Sequence, Structure & Domains
Sequences
Length
359
Mass
40,635
Sequence
MQVPNSTGPDNATLQMLRNPAIAVALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFDVLKWTMLPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRLREYLGCRRVPRDTLDTRRESLFSARTTSVRSEAGAHPEGMEGATRPGLQRQESVF
3D Structural Models
Domain & Motif Annotations
Region
329..359; Disordered
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.