Protein detail

P2RY8

S-geranylgeranyl-glutathione receptor P2RY8 (P2Y purinoceptor 8) (P2Y8)

Entry name P2RY8	UniProt ID Q86VZ1	EVMP confidence score 0.25
Supporting publications (n) 4	Transmembrane count 7	Protein classification Cancer-related genesG-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

S-geranylgeranyl-glutathione receptor P2RY8 (P2Y purinoceptor 8) (P2Y8)

Protein Class (4)

Cancer-related genesG-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteins

Protein Function (4)

G-protein coupled receptors:Adenosine and adenine nucleotide receptors
G-protein coupled receptors:GPCRs excl olfactory receptors
Predicted intracellular proteins
Cancer-related genes

Transmembrane

20..40; Helical; Name=1; 58..78; Helical; Name=2; 89..109; Helical; Name=3; 139..159; Helical; Name=4; 188..208; Helical; Name=5; 238..258; Helical; Name=6; 276..296; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000182162

Entrez Gene Symbol

P2RY8

Gene Synonym

P2Y8

Gene Description

P2Y receptor family member 8

Chromosome

Position

1462581-1537185

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization5

Tissue Specificblood vesselCell SpecificEpididymal efferent duct absorptive cellsSingle-Nuclei Brain SpecificfibroblastBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells

Function & Pathway7

Protein Function (4)

G-protein coupled receptors:Adenosine and adenine nucleotide receptors
G-protein coupled receptors:GPCRs excl olfactory receptors
Predicted intracellular proteins
Cancer-related genes

Cellular Component

GO:0005886 plasma membrane

Molecular Function (2)

Biological Process (3)

KEGG

hsa04080 Neuroactive ligand-receptor interaction

Canonical Pathways

M99 Pid txa2pathway

Mediation Categories

Receptor-signaling mediation

Relations & Evidence45

Ligand-Receptor Signaling (43)

43 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	HPMR	No	Yes	No	Yes	No
receptor	receptor	Surfaceome	No	Yes	No	Yes	No
gpcr	receptor	DGIdb	No	Yes	No	Yes	No
pseudoautosomal_region	receptor	OmniPath	No	Yes	No	Yes	No
gpcr	receptor	Almen2009	No	Yes	No	Yes	No
rhodopsin	receptor	Almen2009	No	Yes	No	Yes	No
gpcr	receptor	UniProt_keyword	No	Yes	No	Yes	No
seven_transmembrane_7tm	receptor	HPMR	No	Yes	No	Yes	No
7tm_a	receptor	HPMR	No	Yes	No	Yes	No
vasopressin_oxytocin_7tm_a	receptor	HPMR	No	Yes	No	Yes	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	ATP1A4 P2RY8	Q13733 Q86VZ1	0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	37633233

Sequence, Structure & Domains6

Sequences

Length

359

Mass

40,635

Sequence

MQVPNSTGPDNATLQMLRNPAIAVALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFDVLKWTMLPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRLREYLGCRRVPRDTLDTRRESLFSARTTSVRSEAGAHPEGMEGATRPGLQRQESVF

Domain & Motif Annotations

Region

329..359; Disordered

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance3

Disease Involvement

Cancer-related genes

Drugs

MC-1

Antibody

HPA003631

Supporting Publications4

PMID	Title	Abstract
33592500	A Proteomic Approach to Understand the Clinical Significance of Acute Myeloid Leukemia-Derived Extracellular Vesicles Reflecting Essential Characteristics of Leukemia.	No abstract available
38207106	Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.	No abstract available
38716512	Assessment of urine sample collection and processing variables for extracellular vesicle-based proteomics.	No abstract available
40189497	Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis.	No abstract available