Protein detail
P2RY8
S-geranylgeranyl-glutathione receptor P2RY8 (P2Y purinoceptor 8) (P2Y8)
Entry name P2RY8 | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 4 | Transmembrane count 7 | Protein classification Cancer-related genesG-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
S-geranylgeranyl-glutathione receptor P2RY8 (P2Y purinoceptor 8) (P2Y8)
Protein Class (4)
Cancer-related genesG-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteins
Protein Function (4)
- G-protein coupled receptors:Adenosine and adenine nucleotide receptors
- G-protein coupled receptors:GPCRs excl olfactory receptors
- Predicted intracellular proteins
- Cancer-related genes
Transmembrane
20..40; Helical; Name=1; 58..78; Helical; Name=2; 89..109; Helical; Name=3; 139..159; Helical; Name=4; 188..208; Helical; Name=5; 238..258; Helical; Name=6; 276..296; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
P2Y8
Gene Description
P2Y receptor family member 8
Chromosome
X
Position
1462581-1537185
Supporting publications (n)
4
EVMP confidence score
0.40
Fluorescence & Localization
Tissue Specificblood vesselCell SpecificEpididymal efferent duct absorptive cellsSingle-Nuclei Brain SpecificfibroblastBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function (4)
- G-protein coupled receptors:Adenosine and adenine nucleotide receptors
- G-protein coupled receptors:GPCRs excl olfactory receptors
- Predicted intracellular proteins
- Cancer-related genes
Cellular Component
Molecular Function (2)
Biological Process (3)
Canonical Pathways
M99 Pid txa2pathway
Mediation Categories
Receptor-signaling mediation
Relations & Evidence45
Ligand-Receptor Signaling (43)
43 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | HPMR | Yes | Yes | |||
| receptor | receptor | Surfaceome | Yes | Yes | |||
| gpcr | receptor | DGIdb | Yes | Yes | |||
| pseudoautosomal_region | receptor | OmniPath | Yes | Yes | |||
| gpcr | receptor | Almen2009 | Yes | Yes | |||
| rhodopsin | receptor | Almen2009 | Yes | Yes | |||
| gpcr | receptor | UniProt_keyword | Yes | Yes | |||
| seven_transmembrane_7tm | receptor | HPMR | Yes | Yes | |||
| 7tm_a | receptor | HPMR | Yes | Yes | |||
| vasopressin_oxytocin_7tm_a | receptor | HPMR | Yes | Yes |
Page 1 of 5Next
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 37633233 |
Sequence, Structure & Domains
Sequences
Length
359
Mass
40,635
Sequence
MQVPNSTGPDNATLQMLRNPAIAVALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFDVLKWTMLPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRLREYLGCRRVPRDTLDTRRESLFSARTTSVRSEAGAHPEGMEGATRPGLQRQESVF
Domain & Motif Annotations
Region
329..359; Disordered
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Supporting Publications4
| PMID | Title | Related sentences |
|---|---|---|
| 33592500 | A Proteomic Approach to Understand the Clinical Significance of Acute Myeloid Leukemia-Derived Extracellular Vesicles Reflecting Essential Characteristics of Leukemia. | No related sentences available |
| 38207106 | Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity. | No related sentences available |
| 38716512 | Assessment of urine sample collection and processing variables for extracellular vesicle-based proteomics. | No related sentences available |
| 40189497 | Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis. | No related sentences available |