Protein detail

LRP11

Low-density lipoprotein receptor-related protein 11 (LRP-11)

Entry name LRP11	UniProt ID Q86VZ4	EVMP confidence score 0.50
Supporting publications (n) 4	Transmembrane count 1	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Low-density lipoprotein receptor-related protein 11 (LRP-11)

Protein Function

Predicted intracellular proteins

Transmembrane

451..473; Helical

Transmembrane Count

Ensembl

ENSG00000120256

Entrez Gene Symbol

LRP11

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Tissue SpecifictestisCell SpecificEarly spermatids

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component

GO:0005886 plasma membrane

Molecular Function

GO:0051219 phosphoprotein binding

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence38

Ligand-Receptor Signaling (37)

37 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	HPMR	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	connectomeDB2020	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
receptor	receptor	talklr	No	Yes	No	Yes	No
receptor	receptor	connectomeDB2020	No	Yes	No	Yes	No
receptor	receptor	iTALK	No	Yes	No	Yes	No
receptor	receptor	Almen2009	No	Yes	No	Yes	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry\|Western blottingMass spectrometryMass spectrometry [LTQ-FT Ultra]Western blotting	3	38014595 30915084 37670049

Sequence, Structure & Domains9

Sequences

Length

500

Mass

53,311

Sequence

MASVAQESAGSQRRLPPRHGALRGLLLLCLWLPSGRAALPPAAPLSELHAQLSGVEQLLEEFRRQLQQERPQEELELELRAGGGPQEDCPGPGSGGYSAMPDAIIRTKDSLAAGASFLRAPAAVRGWRQCVAACCSEPRCSVAVVELPRRPAPPAAVLGCYLFNCTARGRNVCKFALHSGYSSYSLSRAPDGAALATARASPRQEKDAPPLSKAGQDVVLHLPTDGVVLDGRESTDDHAIVQYEWALLQGDPSVDMKVPQSGTLKLSHLQEGTYTFQLTVTDTAGQRSSDNVSVTVLRAAYSTGGCLHTCSRYHFFCDDGCCIDITLACDGVQQCPDGSDEDFCQNLGLDRKMVTHTAASPALPRTTGPSEDAGGDSLVEKSQKATAPNKPPALSNTEKRNHSAFWGPESQIIPVMPDSSSSGKNRKEESYIFESKGDGGGGEHPAPETGAVLPLALGLAITALLLLMVACRLRLVKQKLKKARPITSEESDYLINGMYL

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q86VZ4-1; Sequence=Displayed; Name=2; IsoId=Q86VZ4-2; Sequence=VSP_017535, VSP_017536

Alternative Sequence

205..237; EKDAPPLSKAGQDVVLHLPTDGVVLDGRESTDD -> GKRATEGPALARALETRSALAKLEAKHTRAKLF (in isoform 2); 238..500; Missing (in isoform 2)

Domain & Motif Annotations

Domain (FT)

99..184; MANSC; 210..305; PKD; 309..345; LDL-receptor class A

Region

358..445; Disordered

Protein Families

LDLR family

Sequence Similarities

Belongs to the LDLR family.

Supporting Publications4

PMID	Title	Abstract
27894104	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	No abstract available
29148239	Metabolic Signature of Microvesicles from Umbilical Cord Mesenchymal Stem Cells of Preterm and Term Infants.	No abstract available
29687628	Proteomic Profiling Exosomes from Vascular Smooth Muscle Cell.	No abstract available
39558134	Serum small extracellular vesicles-derived BST2 as a biomarker for papillary thyroid microcarcinoma promotes lymph node metastasis.	No abstract available