Protein detail

LRP11

Low-density lipoprotein receptor-related protein 11 (LRP-11)

Protein symbol LRP11	UniProt ID Q86VZ4	EVMP score 0.50
Frequency 4	Transmembrane count 1	Protein classification

Basic Information

Protein Names

Low-density lipoprotein receptor-related protein 11 (LRP-11)

Protein Function

Predicted intracellular proteins

Transmembrane

451..473; Helical

Transmembrane Count

Ensembl

ENSG00000120256

Entrez Gene Symbol

LRP11

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecifictestisCell SpecificEarly spermatids

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

GO:0005886 plasma membrane

Molecular Function

GO:0051219 phosphoprotein binding

Biological Process

Mediation Categories

Other mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

37 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	HPMR	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	connectomeDB2020	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
receptor	receptor	talklr	No	Yes	No	Yes	No
receptor	receptor	connectomeDB2020	No	Yes	No	Yes	No
receptor	receptor	iTALK	No	Yes	No	Yes	No
receptor	receptor	Almen2009	No	Yes	No	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry\|Western blottingMass spectrometryMass spectrometry [LTQ-FT Ultra]Western blotting	3	38014595 30915084 37670049

Sequence, Structure & Domains

Sequences

Length

500

Mass

53,311

Sequence

MASVAQESAGSQRRLPPRHGALRGLLLLCLWLPSGRAALPPAAPLSELHAQLSGVEQLLEEFRRQLQQERPQEELELELRAGGGPQEDCPGPGSGGYSAMPDAIIRTKDSLAAGASFLRAPAAVRGWRQCVAACCSEPRCSVAVVELPRRPAPPAAVLGCYLFNCTARGRNVCKFALHSGYSSYSLSRAPDGAALATARASPRQEKDAPPLSKAGQDVVLHLPTDGVVLDGRESTDDHAIVQYEWALLQGDPSVDMKVPQSGTLKLSHLQEGTYTFQLTVTDTAGQRSSDNVSVTVLRAAYSTGGCLHTCSRYHFFCDDGCCIDITLACDGVQQCPDGSDEDFCQNLGLDRKMVTHTAASPALPRTTGPSEDAGGDSLVEKSQKATAPNKPPALSNTEKRNHSAFWGPESQIIPVMPDSSSSGKNRKEESYIFESKGDGGGGEHPAPETGAVLPLALGLAITALLLLMVACRLRLVKQKLKKARPITSEESDYLINGMYL

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q86VZ4-1; Sequence=Displayed; Name=2; IsoId=Q86VZ4-2; Sequence=VSP_017535, VSP_017536

Alternative Sequence

205..237; EKDAPPLSKAGQDVVLHLPTDGVVLDGRESTDD -> GKRATEGPALARALETRSALAKLEAKHTRAKLF (in isoform 2); 238..500; Missing (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Domain (FT)

99..184; MANSC; 210..305; PKD; 309..345; LDL-receptor class A

Region

358..445; Disordered

Protein Families

LDLR family

Sequence Similarities

Belongs to the LDLR family.

Clinical Relevance