Protein detail

LIPB1

Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2)

Entry name LIPB1	UniProt ID Q86W92	EVMP confidence score 0.38
Supporting publications (n) 2	Transmembrane count	Protein classification Cancer-related genesPlasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2)

Protein Class (3)

Cancer-related genesPlasma proteinsPredicted intracellular proteins

Protein Function (2)

Predicted intracellular proteins
Cancer-related genes

Ensembl

ENSG00000110841

Entrez Gene Symbol

PPFIBP1

Gene Synonym (4)

hSGT2hSgt2pL2SGT2

Gene Description

PPFIA binding protein 1

Chromosome

Position

27523431-27695564

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization4

Tissue SpecificbrainCell SpecificB-cellsSingle-Nuclei Brain Specificmedium spiny neuronBlood Cell Specificplasmacytoid DC

Function & Pathway6

Protein Function (2)

Predicted intracellular proteins
Cancer-related genes

Cellular Component (5)

Molecular Function (2)

Biological Process (3)

Reactome (5)

Mediation Categories (3)

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediation

Relations & Evidence12

Enzyme-Mediated Modification (2)

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
PPFIBP1	EGF	P01133	S	40	phosphorylation	BEL-Large-Corpus_ProtMapperProtMapper	ProtMapper:17081983
PPFIBP1	EGF	P01133	T	39	phosphorylation	BEL-Large-Corpus_ProtMapperProtMapper	ProtMapper:17081983

Ligand-Receptor Signaling (5)

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (4)

4 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database
HAO2 N4BP1 PPFIBP1 SMG6	O75113 Q86US8 Q86W92 Q9NYQ3	0:0:0:0	hu.MAP2
HAO2 N4BP1 PPFIBP1	O75113 Q86W92 Q9NYQ3	0:0:0	hu.MAP2
ATRIP DCUN1D5 GOLPH3L LSS MLXIP PNKD PPARGC1B PPFIBP1 PRMT9 RADIL SETX	P48449 Q6P2P2 Q7Z333 Q86W92 Q86YN6 Q8N490 Q8WXE1 Q96JH8 Q9BTE7 Q9H4A5 Q9HAP2	0:0:0:0:0:0:0:0:0:0:0	hu.MAP
MLXIP PNKD PPARGC1B PPFIBP1	Q86W92 Q86YN6 Q8N490 Q9HAP2	0:0:0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Size Exclusion Chromatography	Mass spectrometry	1	33204424

Sequence, Structure & Domains12

Sequences

Length

1,011

Mass

114,024

Sequence

MMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTAETLVEWLQSQMTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQKLDLMAEISNLKLKLTAVEKDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKSLMAKLSSMKIKVGQMQYEKQRMEQKWESLKDELASLKEQLEEKESEVKRLQEKLVCKMKGEGVEIVDRDIEVQKMKKAVESLMAANEEKDRKIEDLRQCLNRYKKMQDTVVLAQGKDGEYEELLNSSSISSLLDAQGFSDLEKSPSPTPVMGSPSCDPFNTSVPEEFHTTILQVSIPSLLPATVSMETSEKSKLTPKPETSFEENDGNIILGATVDTQLCDKLLTSSLQKSSSLGNLKKETSDGEKETIQKTSEDRAPAESRPFGTLPPRPPGQDTSMDDNPFGTRKVRSSFGRGFFKIKSNKRTASAPNLAETEKETAEHLDLAGASSRPKDSQRNSPFQIPPPSPDSKKKSRGIMKLFGKLRRSQSTTFNPDDMSEPEFKRGGTRATAGPRLGWSRDLGQSNSDLDMPFAKWTKEQVCNWLMEQGLGSYLNSGKHWIASGQTLLQASQQDLEKELGIKHSLHRKKLQLALQALGSEEETNHGKLDFNWVTRWLDDIGLPQYKTQFDEGRVDGRMLHYMTVDDLLSLKVVSVLHHLSIKRAIQVLRINNFEPNCLRRRPSDENTIAPSEVQKWTNHRVMEWLRSVDLAEYAPNLRGSGVHGGLMVLEPRFNVETMAQLLNIPPNKTLLRRHLATHFNLLIGAEAQHQKRDAMELPDYVLLTATAKVKPKKLAFSNFGNLRKKKQEDGEEYVCPMELGQASGSASKKGFKPGLDMRLYEEDDLDRLEQMEDSEGTVRQIGAFSEGINNLTHMLKEDDMFKDFAARSPSASITDEDSNV

Alternative Products

Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q86W92-1; Sequence=Displayed; Name=2; IsoId=Q86W92-2; Sequence=VSP_009397, VSP_009398, VSP_009399, VSP_009400; Name=3; IsoId=Q86W92-3; Sequence=VSP_009394; Name=4; IsoId=Q86W92-4; Sequence=VSP_009397; Name=5; Synonyms=L2; IsoId=Q86W92-5; Sequence=VSP_009395, VSP_009396

Alternative Sequence

1..153; Missing (in isoform 3); 158..170; ELLSRTSLETQKL -> VCAEARTKMGFPC (in isoform 5); 171..1011; Missing (in isoform 5); 233..263; Missing (in isoform 2 and isoform 4); 302; D -> DENFKKKLKEKN (in isoform 2); 349; K -> KKGK (in isoform 2); 544; L -> LDRKRSASAPTL (in isoform 2)

Domain & Motif Annotations

Compositional Bias

470..492; Basic and acidic residues; 546..556; Basic and acidic residues; 584..598; Basic residues

Coiled Coil

156..405

Domain (CC)

The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type beta/beta. The C-terminal, non-coiled coil regions mediate heterodimerization type beta/alpha and interaction with S100A4..

Domain (FT)

647..711; SAM 1; 719..782; SAM 2; 804..876; SAM 3

Region

420..439; Disordered; 463..634; Disordered

Protein Families (2)

Liprin family
Liprin-beta subfamily

Sequence Similarities

Belongs to the liprin family. Liprin-beta subfamily.

Clinical Relevance5

Disease Involvement (4)

Cancer-related genesDisease variantEpilepsyIntellectual disability

Antibody (2)

HPA001924 HPA071162

Interaction Protein (9)

ENSG00000088986ENSG00000108953ENSG00000128245ENSG00000134308ENSG00000164924ENSG00000166913ENSG00000170027ENSG00000175793ENSG00000264364

Interaction Count

Interaction Dataset (3)

biogrid_opencellintact_biogrid_opencellintact_biogrid

Supporting Publications2

PMID	Title	Abstract
29635386	Amniotic Fluid Exosome Proteomic Profile Exhibits Unique Pathways of Term and Preterm Labor.	Exosomes were isolated by differential centrifugation and quantified using nanocrystals (Qdot) coupled to CD63 and placental alkaline phosphatase (PLAP) by fluorescence nanoparticle tracking analysis.
32384937	Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.	No abstract available