Protein detail

PPR27

Protein phosphatase 1 regulatory subunit 27 (Dysferlin-interacting protein 1) (Toonin)

Entry name PPR27	UniProt ID Q86WC6	EVMP confidence score 0.38
Supporting publications (n) 2	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Protein phosphatase 1 regulatory subunit 27 (Dysferlin-interacting protein 1) (Toonin)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000182676

Entrez Gene Symbol

PPP1R27

Gene Synonym (2)

DYSFIP1toonin

Gene Description

Protein phosphatase 1 regulatory subunit 27

Chromosome

Position

81833492-81835050

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization4

Tissue SpecificesophagusCell SpecificEsophageal apical cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell Specificclassical monocyte

Function & Pathway5

Protein Function

Predicted intracellular proteins

Molecular Function (3)

Biological Process (3)

Canonical Pathways

M99 Pid txa2pathway

Mediation Categories

Other mediation

Relations & Evidence4

Ligand-Receptor Signaling (2)

2 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	AASS AATF ARHGAP12 BYSL LTV1 PPP1R27 RIOK2 RPS11 RPS13 RPS14 RPS15A RPS17 RPS3 UBC	P08708 P0CG48 P23396 P62244 P62263 P62277 P62280 Q13895 Q86WC6 Q8IWW6 Q96GA3 Q9BVS4 Q9NY61 Q9UDR5	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9761

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	5	40985879 37322475 32854315 41307968 38207106

Sequence, Structure & Domains4

Sequences

Length

154

Mass

17,438

Sequence

MPSRTARYARYSPRQRRRRMLADRSVRFPNDVLFLDHIRQGDLEQVGRFIRTRKVSLATIHPSGLAALHEAVLSGNLECVKLLVKYGADIHQRDEAGWTPLHIACSDGYPDIARYLISLGADRDATNDDGDLPSDLIDPDYKELVELFKGTTMD

Domain & Motif Annotations

Repeat

63..92; ANK 1; 96..125; ANK 2

Clinical Relevance1

Antibody (2)

HPA042227 HPA048632

Supporting Publications2

PMID	Title	Abstract
37922300	Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women.	No abstract available
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available