Protein detail

PPR27

Protein phosphatase 1 regulatory subunit 27 (Dysferlin-interacting protein 1) (Toonin)

Entry name PPR27	UniProt ID Q86WC6	EVMP score 0.38
Frequency 2	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Protein phosphatase 1 regulatory subunit 27 (Dysferlin-interacting protein 1) (Toonin)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000182676

Entrez Gene Symbol

PPP1R27

Gene Synonym

DYSFIP1toonin

Gene Description

Protein phosphatase 1 regulatory subunit 27

Chromosome

Position

81833492-81835050

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue SpecificesophagusCell SpecificEsophageal apical cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell Specificclassical monocyte

Function & Pathway

Protein Function

Predicted intracellular proteins

Molecular Function

Biological Process

Canonical Pathways

M99 Pid txa2pathway

Mediation Categories

Other mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

2 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	AASS AATF ARHGAP12 BYSL LTV1 PPP1R27 RIOK2 RPS11 RPS13 RPS14 RPS15A RPS17 RPS3 UBC	P08708 P0CG48 P23396 P62244 P62263 P62277 P62280 Q13895 Q86WC6 Q8IWW6 Q96GA3 Q9BVS4 Q9NY61 Q9UDR5	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9761

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	5	40985879 37322475 32854315 41307968 38207106

Sequence, Structure & Domains

Sequences

Length

154

Mass

17,438

Sequence

MPSRTARYARYSPRQRRRRMLADRSVRFPNDVLFLDHIRQGDLEQVGRFIRTRKVSLATIHPSGLAALHEAVLSGNLECVKLLVKYGADIHQRDEAGWTPLHIACSDGYPDIARYLISLGADRDATNDDGDLPSDLIDPDYKELVELFKGTTMD

3D Structural Models

Domain & Motif Annotations

Repeat

63..92; ANK 1; 96..125; ANK 2

Clinical Relevance

Antibody

HPA042227 HPA048632