Protein detail

RASF3

Ras association domain-containing protein 3

Entry name RASF3	UniProt ID Q86WH2	EVMP confidence score 0.38
Supporting publications (n) 2	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information10

Protein Names

Ras association domain-containing protein 3

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000153179

Entrez Gene Symbol

RASSF3

Gene Description

Ras association domain family member 3

Chromosome

Position

64507001-64697564

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization6

Tissue SpecificbrainCell SpecificAdrenal medulla cellsBlood Cell SpecificNK-cellBlood Lineage SpecificNK-cellsSecretome LocationSecreted in other tissuesSecretome FunctionReceptor

Function & Pathway4

Protein Function

Predicted intracellular proteins

Cellular Component (4)

Molecular Function (2)

Mediation Categories

Other mediation

Relations & Evidence5

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	40689422

Sequence, Structure & Domains8

Sequences

Length

238

Mass

27,562

Sequence

MSSGYSSLEEDAEDFFFTARTSFFRRAPQGKPRSGQQDVEKEKETHSYLSKEEIKEKVHKYNLAVTDKLKMTLNSNGIYTGFIKVQMELCKPPQTSPNSGKLSPSSNGCMNTLHISSTNTVGEVIEALLKKFLVTESPAKFALYKRCHREDQVYACKLSDREHPLYLRLVAGPRTDTLSFVLREHEIGEWEAFSLPELQNFLRILDKEEDEQLQNLKRRYTAYRQKLEEALREVWKPD

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=A; IsoId=Q86WH2-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q86WH2-2; Sequence=VSP_019353, VSP_019354

Alternative Sequence

74..90; NSNGIYTGFIKVQMELC -> STPASSQTGNIHSTCVW (in isoform 2); 91..238; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

38..48; Basic and acidic residues

Domain (FT)

79..186; Ras-associating; 187..234; SARAH

Region

26..48; Disordered

Clinical Relevance4

Antibody (3)

CAB022664 CAB034035 HPA038469

Interaction Protein (4)

ENSG00000101109ENSG00000101558ENSG00000104375ENSG00000189067

Interaction Count

Interaction Dataset (3)

intact_biogrid_opencellbiogrid_opencellintact_biogrid

Supporting Publications2

PMID	Title	Abstract
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No abstract available
38207106	Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.	No abstract available